Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jean Hedrick"'
Autor:
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom
Publikováno v:
eLife, Vol 11 (2022)
Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectr
Externí odkaz:
https://doaj.org/article/e2f24e41f41645fe97c9ca6615d7120b
Autor:
Westley J Friesen, Briana Johnson, Jairo Sierra, Jin Zhuo, Priya Vazirani, Xiaojiao Xue, Yuki Tomizawa, Ramil Baiazitov, Christie Morrill, Hongyu Ren, Suresh Babu, Young-Choon Moon, Art Branstrom, Anna Mollin, Jean Hedrick, Josephine Sheedy, Gary Elfring, Marla Weetall, Joseph M Colacino, Ellen M Welch, Stuart W Peltz
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0206158 (2018)
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are responsible for thousands of inherited diseases. Readthrough of premature stop codons by small molecule drugs has emerged as a promising therapeutic approa
Externí odkaz:
https://doaj.org/article/dce988ac8f214e27afc02d4bfe8cf531
Autor:
Liangxian Cao, Marla Weetall, Jenelle Bombard, Hongyan Qi, Tamil Arasu, William Lennox, Jean Hedrick, Josephine Sheedy, Nicole Risher, Peter C Brooks, Panayiota Trifillis, Christopher Trotta, Young-Choon Moon, John Babiak, Neil G Almstead, Joseph M Colacino, Thomas W Davis, Stuart W Peltz
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168366 (2016)
Current anti-VEGF (Vascular Endothelial Growth Factor A) therapies to treat various cancers indiscriminately block VEGF function in the patient resulting in the global loss of VEGF signaling which has been linked to dose-limiting toxicities as well a
Externí odkaz:
https://doaj.org/article/429e9fa300c64e3997b2fda5fbe6a256
Autor:
Stuart W. Peltz, Joseph M. Colacino, Art Branstrom, Neil G. Almstead, Allan Jacobson, Thomas W. Davis, John Babiak, Young-Choon Moon, Janet Petruska, Ronald Kong, William Lennox, Seongwoo Hwang, Tamil Arasu, Hongyan Qi, Shirley Yeh, Nicole Risher, Jean Hedrick, Josephine Sheedy, Joshua Du, Wencheng Li, Jason D. Graci, Charles Romfo, Bansri Furia, Min Jung Kim, Jiyuan Ma, Katherine Cintron, Christopher Trotta, Marla Weetall, Liangxian Cao
PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we performed extensive biological characterization of the activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b38cf3c29f914ea98d3f3c7be961d2f
https://doi.org/10.1158/1535-7163.c.6539454.v1
https://doi.org/10.1158/1535-7163.c.6539454.v1
Autor:
Stuart W. Peltz, Joseph M. Colacino, Art Branstrom, Neil G. Almstead, Allan Jacobson, Thomas W. Davis, John Babiak, Young-Choon Moon, Janet Petruska, Ronald Kong, William Lennox, Seongwoo Hwang, Tamil Arasu, Hongyan Qi, Shirley Yeh, Nicole Risher, Jean Hedrick, Josephine Sheedy, Joshua Du, Wencheng Li, Jason D. Graci, Charles Romfo, Bansri Furia, Min Jung Kim, Jiyuan Ma, Katherine Cintron, Christopher Trotta, Marla Weetall, Liangxian Cao
Supplementary Figures S1-S7: Supplementary Figure S1 shows chemical Synthesis and biological characterization of PTC299. Supplementary Figure S2 shows generation and characterization of PTC299-resistant HT1080 cells. Supplementary Figure 3 shows that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ac4776ab8dbd1c4bd81dcd8bb2dab7
https://doi.org/10.1158/1535-7163.22509942
https://doi.org/10.1158/1535-7163.22509942
Autor:
Stuart W. Peltz, Joseph M. Colacino, Art Branstrom, Neil G. Almstead, Allan Jacobson, Thomas W. Davis, John Babiak, Young-Choon Moon, Janet Petruska, Ronald Kong, William Lennox, Seongwoo Hwang, Tamil Arasu, Hongyan Qi, Shirley Yeh, Nicole Risher, Jean Hedrick, Josephine Sheedy, Joshua Du, Wencheng Li, Jason D. Graci, Charles Romfo, Bansri Furia, Min Jung Kim, Jiyuan Ma, Katherine Cintron, Christopher Trotta, Marla Weetall, Liangxian Cao
contains the raw data from the Microarrays study in the PTC299-resistant HT1080 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ffd21a73c725157d53ebd64ecdca72
https://doi.org/10.1158/1535-7163.22509948.v1
https://doi.org/10.1158/1535-7163.22509948.v1
Autor:
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242c3ecb2516113bcfac9a95f12d9626
https://doi.org/10.7554/elife.67447.sa2
https://doi.org/10.7554/elife.67447.sa2
Autor:
Ioannis Dragatsis, Tobias A. Krussig, Monica Salani, Dadi Gao, Paula Dietrich, Vijayalakshmi Gabbeta, Nikolai Naryshkin, Connor M. Montgomery, Susan A. Slaugenhaupt, Jana Narasimhan, Michael E. Talkowski, Marla Weetall, Chien-Ping Ko, Xin Zhao, Chiara Mazzasette, Jean Hedrick, Brooke Swain, Elisabetta Morini, Gregory R. Wojtkiewicz, Amal Dakka
Publikováno v:
The American Journal of Human Genetics. 104:638-650
Familial dysautonomia (FD) is a recessive neurodegenerative disease caused by a splice mutation in Elongator complex protein 1 (ELP1, also known as IKBKAP); this mutation leads to variable skipping of exon 20 and to a drastic reduction of ELP1 in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839b7335a4e62b5656a0551218d76c66
https://doi.org/10.1016/j.ajhg.2019.02.009
https://doi.org/10.1016/j.ajhg.2019.02.009
Autor:
Jiyuan Ma, Thomas W. Davis, Young-Choon Moon, Hongyan Qi, Stuart W. Peltz, Janet Petruska, Neil Gregory Almstead, Nicole Risher, Art Branstrom, Jean Hedrick, Seongwoo Hwang, Katherine Cintron, William Joseph Lennox, Charles M. Romfo, Tamil Arasu, Liangxian Cao, Josephine Sheedy, John Babiak, Min Jung Kim, Ronald Kong, Wencheng Li, Jason D. Graci, Allan Jacobson, Shirley Yeh, Christopher R. Trotta, Joshua Du, Joseph M. Colacino, Bansri Furia, Marla Weetall
Publikováno v:
Molecular Cancer Therapeutics. 18:3-16
PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we performed extensive biological characterization of the activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc21306fbe053e0ead2cdd503bd008ff
https://doi.org/10.1158/1535-7163.mct-18-0863
https://doi.org/10.1158/1535-7163.mct-18-0863
Autor:
Jiashi Wang, John D. Baird, Neil Gregory Almstead, Marla Weetall, Yi Jin Kim Gorske, Jean Hedrick, Jana Narasimhan, Aleksey I. Gerasyuto, Tamil Arasu, Srinivasa Peddi, Wu Du, Michael Arnold, Josephine Sheedy, Gary Mitchell Karp, Stanley W. Lue, Guy Lagaud, Arthur Branstrom, J. V. N. Vara Prasad, Ginzburg Olya
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(22)
The continued emergence of bacteria resistant to current standard of care antibiotics presents a rapidly growing threat to public health. New chemical entities (NCEs) to treat these serious infections are desperately needed. Herein we report the disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b816934842e2deccf43233dd9921a40
https://pubmed.ncbi.nlm.nih.gov/29032026
https://pubmed.ncbi.nlm.nih.gov/29032026