Metformin selectively targets redox control of complex I energy transduction

Autor: Amy R. Cameron, Lisa Logie, Kashyap Patel, Stefan Erhardt, Sandra Bacon, Paul Middleton, Jean Harthill, Calum Forteath, Josh T. Coats, Calum Kerr, Heather Curry, Derek Stewart, Kei Sakamoto, Peter RepiÅ¡Äák, Martin J. Paterson, Ilmo Hassinen, Gordon McDougall, Graham Rena

Publikováno v: Redox Biology, Vol 14, Iss , Pp 187-197 (2018)

Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that

Externí odkaz: https://doaj.org/article/4594871bfca64daf88a105477355aaec

Cellular Responses to the Metal-Binding Properties of Metformin

Autor: Alan R. Prescott, Sandra Bacon, Lin Xue, Kashyap A. Patel, Lisa Logie, Kei Sakamoto, Hua Jiang, Katherine Macrae, Huan-Huan Wang, Graham Rena, Jean Harthill, D. Lee Hamilton, Gordon J. McDougall

Publikováno v: Diabetes

In recent decades, the antihyperglycemic biguanide metformin has been used extensively in the treatment of type 2 diabetes, despite continuing uncertainty over its direct target. In this article, using two independent approaches, we demonstrate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f6c6521f12b444d3216d388b24f155
https://doi.org/10.2337/db11-0961

Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose

Autor: Barry Hon Cheung Wong, Jean Harthill, Carol MacKintosh, Mark Peggie, Jonas Borch, Nick Morrice, Sarah E. M. Meek

Publikováno v: Harthill, J E, Meek, S E M, Morrice, N, Peggie, M W, Borch, J, Wong, B H C & Mackintosh, C 2006, ' Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose ', Plant Journal, vol. 47, no. 2, pp. 211-223 . https://doi.org/10.1111/j.1365-313X.2006.02780.x

Udgivelsesdato: 2006-Jul Trehalose-6-phosphate is a 'sugar signal' that regulates plant metabolism and development. The Arabidopsis genome encodes trehalose-6-phosphate synthase (TPS) and trehalose-6-phosphatase (TPP) enzymes. It also encodes class I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a776e3cf496e012634af519da30152b
https://doi.org/10.1111/j.1365-313x.2006.02780.x

Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

Autor: Anna Kulma, Dorthe Villadsen, Sarah E. M. Meek, Carol MacKintosh, David G. Campbell, Tom Hamborg Nielsen, Jean Harthill

Publikováno v: The Plant Journal. 37:654-667

Fructose 2,6-bisphosphate (fru-2,6-P2) is a signalling metabolite that regulates photosynthetic carbon partitioning in plants. The content of fru-2,6-P2 in Arabidopsis leaves varied in response to photosynthetic activity with an abrupt decrease at th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc6473d61455d2d2154e223b7723d10
https://doi.org/10.1111/j.1365-313x.2003.01992.x

Glycan modification of a thermostable recombinant (1-3,1-4)-?-glucanase secreted fromSaccharomyces cerevisiae is determined by strain and culture conditions

Autor: Ole Olsen, Bent O. Petersen, Morten Meldgaard, Jean Harthill

Publikováno v: Glycoconjugate Journal. 12:380-390

High level biosynthesis and secretion of the thermostable hybrid (1-3, 1-4)- beta-glucanase H(A16-M) has been achieved in Saccharomyces cerevisiae by means of the yeast vacuolar endoprotease B promoter (PRB1P) and the Bacillus macerans (1-3, 1-4)-bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7be512e530b2b39aa20e0b5864b75f3
https://doi.org/10.1007/bf00731341