Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jean Hélie"'
Autor:
Matthieu Chavent, Anna L. Duncan, Patrice Rassam, Oliver Birkholz, Jean Hélie, Tyler Reddy, Dmitry Beliaev, Ben Hambly, Jacob Piehler, Colin Kleanthous, Mark S. P. Sansom
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
In Escherichia coli, outer membrane protein (OMP) cluster and form islands, but the origin and behaviour of those clusters remains poorly understood. Here authors use coarse grained molecular dynamics simulation and show that their mesoscale simulati
Externí odkaz:
https://doaj.org/article/19638c51dad4423f8b459af3fd0c85a4
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 10, p e1003911 (2014)
Cell membranes are complex multicomponent systems, which are highly heterogeneous in the lipid distribution and composition. To date, most molecular simulations have focussed on relatively simple lipid compositions, helping to inform our understandin
Externí odkaz:
https://doaj.org/article/d950336904b948799da4ec62ebc64cba
Autor:
Anna L. Duncan, Tyler Reddy, Heidi Koldsø, Jean Hélie, Philip W. Fowler, Matthieu Chavent, Mark S. P. Sansom
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Cell membranes are crowded and complex environments. To investigate the effect of protein-lipid interactions on dynamic organization in mammalian cell membranes, we have performed coarsegrained molecular dynamics simulations containing >100 copies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fdba3bac632ae2a068b5d48fb8c5bb50
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
How Nanoscale Protein Interactions Determine the Mesoscale Dynamic Organisation of Membrane Proteins
Autor:
Maximillian A.R. Bandurka, Wanling Song, Mark S.P. Sansom, Jacob Piehler, Oliver Birkholz, Patrice Rassam, Matthieu Chavent, Tyler Reddy, Anna L. Duncan, Jean Hélie, Dmitry Beliaev, Colin Kleanthous, Ben Hambly
Publikováno v:
Biophysical Journal. 116:365a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c9c50fa731573839bcd2e755bf638bc
https://doi.org/10.1016/j.bpj.2018.11.1984
https://doi.org/10.1016/j.bpj.2018.11.1984
Autor:
Heidi Koldsø, Philip W. Fowler, Jean Hélie, Matthieu Chavent, Mark S.P. Sansom, Anna L. Duncan
Publikováno v:
Soft Matter. 12(37)
The ease with which a cell membrane can bend and deform is important for a wide range of biological functions. Peripheral proteins that induce curvature in membranes (e.g. BAR domains) have been studied for a number of years. Little is known, however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f5ecdf78c812b7f87044b2f9875447
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Membrane active peptides are therapeutically relevant for a variety of purposes. However a better understanding of their mechanisms of interaction with lipid bilayers is needed in order to maximise both efficiency and selectivity. In the case of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cffa9ab05d6cccae663ca0c2b034efb
https://ora.ox.ac.uk/objects/uuid:51553736-121a-4db1-b0e1-db2b43af1ee3
https://ora.ox.ac.uk/objects/uuid:51553736-121a-4db1-b0e1-db2b43af1ee3
Publikováno v:
Biophysical Journal. 110(3)
It is well-established that membranes are complex, crowded environments but better understanding is needed of the in vivo molecular-level organization. High resolution structures are static or capture only isolated parts of the whole system. Super re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba10c52eccf0f38920d4f4c1dfb49a2
Autor:
Jean Hélie, Anna L. Duncan, Mark S.P. Sansom, Joseph E. Goose, Colin Kleanthous, Tyler Reddy, Patrice Rassam, Matthieu Chavent
Publikováno v:
Biophysical Journal. 110(3)
With recent improvements in both experimental and computational techniques it is now possible to gain insight into increasingly complex biomembrane systems. Combination of experiments and modelling has revealed the presence of “islands” of dimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095de001f08b906d8606f54e512d34be
Autor:
Jacob Piehler, Jean Hélie, Ben Hambly, Colin Kleanthous, Mark S.P. Sansom, Patrice Rassam, Matthieu Chavent, Oliver Birkholz, Tyler Reddy, Dmitry Belyaev, Anna L. Duncan
Publikováno v:
Biophysical Journal. 114:391a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4683d26dc6618531e950835b291dbba2
https://doi.org/10.1016/j.bpj.2017.11.2163
https://doi.org/10.1016/j.bpj.2017.11.2163
Publikováno v:
Biophysical Journal. 112:320a
It is well-understood that cell membranes are crowded and complex environments, containing up to 50 % protein by mass [1] and comprised of myriad types of lipid species [2]. Less well understood is the molecular detail of the effects of complexity an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c67bb94c324f87ede17869158950ea00
https://doi.org/10.1016/j.bpj.2016.11.1732
https://doi.org/10.1016/j.bpj.2016.11.1732