Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jean Grisouard"'
Publikováno v:
Haematologica, Vol 99, Iss 4 (2014)
Externí odkaz:
https://doaj.org/article/12d51708007547209674350d9e05ad90
Publikováno v:
Experimental hematology
Major progress has been recently made in understanding the molecular pathogenesis of myeloproliferative neoplasms (MPN). Mutations in one of four genes-JAK2, MPL, CALR, and CSF3R-can be found in the vast majority of patients with MPN and represent dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f446f29990102f1e81f6c3eec59126
Autor:
Takafumi Shimizu, Lucia Kubovcakova, Adrian Duek, Jean Grisouard, Radek C. Skoda, Stephan Dirnhofer, Hui Hao-Shen
Publikováno v:
Blood
The acquired somatic JAK2-V617F mutation is present in >80% of patients with myeloproliferative neoplasms (MPNs). Stat3 plays a role in hematopoietic homeostasis and might influence the JAK2-V617F-driven MPN phenotype. We crossed our transgenic SclCr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf688785f42e52c8b8dbe26265052364
Autor:
Stephan Dirnhofer, Lucia Kubovcakova, Hui Hao-Shen, Takafumi Shimizu, Jean Grisouard, Axel Karow, Pontus Lundberg, Adrian Duek, Radek C. Skoda
Publikováno v:
Blood
The interferon-γ (IFNγ)/signal transducer and activator of transcription 1 (Stat1) pathway shows higher activity in patients with essential thrombocythemia (ET) than in polycythemia vera (PV) and was proposed to be promoting the ET phenotype. We ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fa85d00b42ace3f6e9d9ab34d977c1
https://doi.org/10.1182/blood-2013-07-514208
https://doi.org/10.1182/blood-2013-07-514208
Autor:
Jean Grisouard, Kaethi Dembinski, Mirjam Christ-Crain, Beat Müller, Daniel M. Frey, Tanja Herzog-Radimerski, Ulrich Keller, Henryk Zulewski, Nadine S. Sauter, Katharina Timper, Ralph Peterli
Publikováno v:
American journal of physiology. Endocrinology and metabolism
Obesity-related insulin resistance is linked to a chronic state of systemic and adipose tissue-derived inflammation. Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone also acting on adipocytes. We investigated whether GIP affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6baff4b1950414a4fede2637b14d6f
https://doi.org/10.1152/ajpendo.00100.2012
https://doi.org/10.1152/ajpendo.00100.2012
Autor:
Mirjam Christ-Crain, Tanja Radimerski, Jean Grisouard, Beat Müller, Katharina Timper, Henryk Zulewski, Ulrich Keller
Publikováno v:
Innate immunity
Severe systemic infections induce ubiquitous calcitonin (CALC) gene expression with release of calcitonin peptides, namely procalcitonin, calcitonin gene-related peptide and adrenomedullin. Using an in vitro model for bacterial infection, we tested t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d29423610f9d5a72ed158c20053e8d3
Autor:
Daniel M. Frey, Paul C. Herrmann, Ulrich Keller, Henryk Zulewski, Blerina Kola, Tanja Radimerski, Mirjam Christ-Crain, Ralph Peterli, Katharina Timper, Márta Korbonits, Jean Grisouard, Beat Müller, Stephan Krähenbühl
Publikováno v:
Biochemical Pharmacology. 80:1736-1745
The mechanisms of metformin effects on glucose transport and metabolism were investigated in human adipocytes. Human preadipocytes obtained from surgical biopsies were differentiated in vitro into adipocytes and the effects of metformin on glucose up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f957a2574e4e593b90129b274d4826
https://doi.org/10.1016/j.bcp.2010.08.021
https://doi.org/10.1016/j.bcp.2010.08.021
Autor:
Doris Mayer, Jean Grisouard
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 117:87-92
Protein kinases represent key nodes for the integration of multiple intracellular signalling pathways, resulting in modulation of both ligand-dependent and ligand-independent mechanisms of sex steroid receptor (sSR) signalling cascades. The proline-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79d623ba12249eebfa5bf8072e134d8
https://doi.org/10.1016/j.jsbmb.2009.08.002
https://doi.org/10.1016/j.jsbmb.2009.08.002
Autor:
Harald Enzmann, Ashish Shukla, Jean Grisouard, Alexander Hermani, Doris Mayer, Volker Ehemann
Publikováno v:
Endocrine-Related Cancer. 16:429-441
Insulin and insulin analogs stimulate proliferation of human mammary epithelial cells. We identified and analyzed the signaling pathways related to cell proliferation induced by regular insulin and by four insulin analogs presently approved for thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623afbb5f779379f059be9e5ea6ac3bd
https://doi.org/10.1677/erc-08-0240
https://doi.org/10.1677/erc-08-0240
Autor:
Thomas Radimerski, Hui Hao-Shen, Tata Nageswara Rao, Lucia Kubovcakova, Vincent Romanet, Sai Li, Stephan Dirnhofer, Jean Grisouard, Pontus Lundberg, Sara C. Meyer, Radek C. Skoda, Masato Murakami
Publikováno v:
Blood. 128(6)
Mutations in JAK2 exon 12 are frequently found in patients with polycythemia vera (PV) that do not carry a JAK2-V617F mutation. The majority of these patients display isolated erythrocytosis. We generated a mouse model that expresses JAK2-N542-E543de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99483f97f6baf908615fb4ced3491fa6
https://pubmed.ncbi.nlm.nih.gov/27516428
https://pubmed.ncbi.nlm.nih.gov/27516428