Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jean Gekas"'
Autor:
Erica Soster, Tamara Mossfield, Melody Menezes, Gloudi Agenbag, Marie-Line Dubois, Jean Gekas, Tristan Hardy, Kelly Loggenberg, on behalf of the Global Expanded NIPT Consortium
Publikováno v:
Molecular Cytogenetics, Vol 17, Iss 1, Pp 1-7 (2024)
Abstract Trisomy 20 has been shown to be one of the most frequent rare autosomal trisomies in patients that undergo genome-wide noninvasive prenatal testing. Here, we describe the clinical outcomes of cases that screened positive for trisomy 20 follo
Externí odkaz:
https://doaj.org/article/634db5f3cfe74ed4a291f924099049a6
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionPreeclampsia (PE) is a leading cause of maternal and perinatal morbidity worldwide. However, current methods of screening are complicated and require special skill sets. In this observational study of prospectively collected samples, we w
Externí odkaz:
https://doaj.org/article/85e341fbea1445619111c4337e5758db
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Noninvasive prenatal testing (NIPT) using cell-free DNA (cfDNA) is typically carried out to screen for common fetal chromosomal anomalies, with the option to screen for a wider range of chromosomal changes (expanded NIPT) becoming incre
Externí odkaz:
https://doaj.org/article/8be36c039d014b41af31abb5573f7a2f
Autor:
Tamara Mossfield, Erica Soster, Melody Menezes, Gloudi Agenbag, Marie-Line Dubois, Jean Gekas, Tristan Hardy, Monika Jurkowska, Pascale Kleinfinger, Kelly Loggenberg, Pablo Marchili, Roberto Sirica, on behalf of the Global Expanded NIPT Consortium
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Cell-free (cf) DNA screening is a noninvasive prenatal screening approach that is typically used to screen for common fetal trisomies, with optional screening for sex chromosomal aneuploidies and fetal sex. Genome-wide cfDNA screening can screen for
Externí odkaz:
https://doaj.org/article/563126c106e74772acf05d567fbd0f6f
Autor:
Christine Desbiens, Nathalie Côté, Madeleine Côté, Brigitte Poirier, Alexandra Sebastianelli, Stéphane Roy, Sabrina Lavoie, Valérie Faucher, Carmen Brisson, Philippe Lachapelle, Sylvain Fortier, Marie-Claude Roy, Tania Cruz-Marino, Isabelle Gosselin, Michel Dorval, Karine Boisvert, Hermann Nabi, Nelson Charette, Marie-Claude Renaud, Jean Gekas, Maude Laberge, Julie Lapointe, Martin Beaumont, Jacques Simard, Johanne Hébert, Jason R. Guertin, Marie-Ève Dubeau, Jocelyne Chiquette, Maria-Gabriela Ruizmangas, Josianne Leblanc, Sylvain Gagnon, Marie-Pascale Pomey, Arnaud Blanchet Saint-Pierre, Lysanne Castonguay, Marie Plante, Karine Bouchard, Omar Touhami, Marie-Michelle Racine, Josée Rhéaume, Yann Joly, Claire Brousseau
Publikováno v:
Cancers, Vol 13, Iss 2729, p 2729 (2021)
Cancers
Cancers
Simple Summary We recently developed an oncogenetic model to overcome the unprecedented demand for genetic counseling and testing for hereditary breast and ovarian cancer. Quality and performance indicators showed that the implementation of this mode
Publikováno v:
Genetics in Medicine. 24:S300
Autor:
Yves Giguère, Daniel Reinharz, Léon Nshimyumukiza, François Audibert, Jean Gekas, Jean-Alexandre Beaumont, Sylvie Langlois, Christian Gagné, Christopher McCabe, Julian Little, Julie Duplantie, François Rousseau
Publikováno v:
Journal of Obstetrics and Gynaecology Canada. 40:48-60
Objective Yearly, 450 000 pregnant Canadians are eligible for voluntary prenatal screening for trisomy 21. Different screening strategies select approximately 4% of women for invasive fetal chromosome testing. Non-invasive prenatal testing (NIPT) usi
Autor:
Naomi Meeks, Diana M. Toledo, Heather Mason-Suares, M Cristina Pacheco, Matthew S. Lebo, David Sharpe, Katherine A Lafferty, Jean Gekas, Thomas E. Mullen
Publikováno v:
European Journal of Human Genetics. 25:509-511
Gain-of-function variants in some RAS–MAPK pathway genes, including PTPN11 and NRAS, are associated with RASopathies and/or acquired hematological malignancies, most notably juvenile myelomonocytic leukemia (JMML). With rare exceptions, the spectru
Autor:
André Caron, Julian Little, Sylvie Langlois, François Audibert, Jean-Claude Forest, Jo-Ann Johnson, François Rousseau, Jean Gekas, Melanie Pastuck, Amélie Tétu, Keli Harrington, Hasna Meddour
Publikováno v:
Prenatal diagnosis. 37(12)
OBJECTIVE This study evaluates the impact of offering cell-free DNA (cfDNA) screening as a first-tier test for trisomies 21 and 18. METHODS This is a prospective study of pregnant women undergoing conventional prenatal screening who were offered cfDN
Autor:
Nicolas B. Huot, Carl Lebel, Christine Dufour, Sébastien Goudenege, Joël Rousseau, Jacques P. Tremblay, Jean Gekas, Isao Fujii
Publikováno v:
Molecular Therapy. 20:2153-2167
Human embryonic stem cells (hESCs) and human-induced pluripotent stem cells (hiPSCs) have an endless self-renewal capacity and can theoretically differentiate into all types of lineages. They thus represent an unlimited source of cells for therapies