Zobrazeno 1 - 10 of 64 pro vyhledávání: '"Jean Francois Rossignol"'
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Akademický článek
The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein
Autor: Sara Piacentini, Anna Riccio, Silvia Santopolo, Silvia Pauciullo, Simone La Frazia, Antonio Rossi, Jean-Francois Rossignol, M. Gabriella Santoro
Publikováno v: Frontiers in Microbiology, Vol 14 (2023)
Coronaviridae is recognized as one of the most rapidly evolving virus family as a consequence of the high genomic nucleotide substitution rates and recombination. The family comprises a large number of enveloped, positive-sense single-stranded RNA vi
Externí odkaz: https://doaj.org/article/826806e5adb840b3a329ab74b0d9b6c5
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3
The Modulation of Cholesterol Metabolism Is Involved in the Antiviral Effect of Nitazoxanide
Autor: Sergio Strizzi, Mario Clerici, Claudia Vanetti, Claudio Fenizia, Mara Biasin, Salomè Valentina Ibba, Daria Trabattoni, Jean Francois Rossignol
Publikováno v: Infectious Disease Reports, Vol 13, Iss 60, Pp 636-644 (2021)
Infectious Disease Reports
Volume 13
Issue 3
Pages 60-644
We previously investigated the role of Nitazoxanide (NTZ), a thiazolide endowed with antiviral and antiparasitic activity, in HIV-1 infection. NTZ treatment in primary isolated PBMCs was able to reduce HIV-1 infection in vitro by inducing the express
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010b2647f119240db1f684cf71328963
https://www.mdpi.com/2036-7449/13/3/60
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4
The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein
Autor: Sara Piacentini, Anna Riccio, Silvia Santopolo, Silvia Pauciullo, Simone La Frazia, Antonio Rossi, Jean-Francois Rossignol, M. Gabriella Santoro
Coronaviridaeis recognized as one of the most rapidly evolving virus family as a consequence of the high genomic nucleotide substitution rates and recombination. The family comprises a large number of enveloped, positive-sense single-stranded RNA vir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31c9e744f5989f7cb6e53491ca20ed38
https://doi.org/10.1101/2022.07.13.499346
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5
Viral burden, inflammatory milieu and CD8 + T‐cell responses to influenza virus in a second‐generation thiazolide (RM‐5061) and oseltamivir combination therapy study
Autor: Marios Koutsakos, Aeron C. Hurt, Katherine Kedzierska, Luca Hensen, Edin J Mifsud, Francesca A. Mercuri, Jean-Francois Rossignol, Lukasz Kedzierski, Simone Nüssing, Zhongfang Wang
Publikováno v: Influenza and Other Respiratory Viruses. 14:678-687
BACKGROUND: Influenza viruses cause significant morbidity and mortality, especially in young children, elderly, pregnant women and individuals with co-morbidities. Patients with severe influenza disease are typically treated with one neuraminidase in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25c5107526be6a72e68fb0897772068a
https://doi.org/10.1111/irv.12776
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6
Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence
Autor: Anna Riccio, Silvia Santopolo, Antonio Rossi, Sara Piacentini, Jean-Francois Rossignol, M. Gabriella Santoro
Publikováno v: Cellular and molecular life sciences (Print. ed.) 79 (2022). doi:10.1007/s00018-022-04246-w
info:cnr-pdr/source/autori:Riccio, Anna; Santopolo, Silvia; Rossi, Antonio; Piacentini, Sara; Rossignol, Jean-Francois; Santoro, M. Gabriella/titolo:Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence/doi:10.1007%2Fs00018-022-04246-w/rivista:Cellular and molecular life sciences (Print. ed.)/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:79
SARS-CoV-2, the causative agent of COVID-19, has caused an unprecedented global health crisis. The SARS-CoV-2 spike, a surface-anchored trimeric class-I fusion glycoprotein essential for viral entry, represents a key target for developing vaccines an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d083da399b0c55dd37ee03ec11d83381
https://pubmed.ncbi.nlm.nih.gov/35391601
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8
Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts
Autor: Jean-Francois Rossignol, M. Gabriella Santoro, Simone La Frazia, Paul M. O'Neill, Sara Piacentini, Andrew V. Stachulski, Sophie L Pate, Rudi Aerts, Etienne Pascal, Joshua Taujanskas, Craig M. Robertson
Publikováno v: FUTURE MEDICINAL CHEMISTRY
Background: The thiazolides, typified by nitazoxanide, are an important class of anti-infective agents. A significant problem with nitazoxanide and its active circulating metabolite tizoxanide is their poor solubility. Results: We report the preparat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736ae33573ffc4d5a19e3b9f87370120
http://hdl.handle.net/2108/299247
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9
Systemic efficacy on Cryptosporidium parvum infection of aminoxanide (RM-5061), a new amino-acid ester thiazolide prodrug of tizoxanide
Autor: Jean-Francois Rossignol, Loïc Favennec, Gilles Gargala, Arnaud François, Andrew V. Stachulski, Damien Costa, Romy Razakandrainibe, El Hadji Ibrahima Diawara
Publikováno v: Parasitology
Parasitology, Cambridge University Press (CUP), 2021, pp.1-10. ⟨10.1017/S0031182021000524⟩
Cryptosporidiosis is a gastrointestinal illness with profuse diarrhoea. Although there are no other Food and Drug Administration (FDA)-approved alternatives for the treatment of cryptosporidiosis, nitazoxanide (NTZ) can be qualified as partially effe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aea4b7c32442604c710038e14d7eed7
https://hal-normandie-univ.archives-ouvertes.fr/hal-03238731
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