Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jean Francois Blain"'
Autor:
Tanja Blume, Severin Filser, Anna Jaworska, Jean-Francois Blain, Gerhard Koenig, Katrin Moschke, Stefan F. Lichtenthaler, Jochen Herms
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Beta-site amyloid-precursor-protein cleaving enzyme 1 (BACE1) is the rate limiting protease in the production of the amyloid-beta peptide (Aβ), which is considered to be the causative agent in the pathogenesis of Alzheimer’s Disease (AD). Therefor
Externí odkaz:
https://doaj.org/article/f771853a2ac843e2a4813c8b74b84943
Autor:
Deirdre Murphy, Sudarshan Kapadnis, Bryce Alden Harrison, Hilliary E Van Voorhies, Jean-Francois Blain, Emily A. Freeman, Jeffrey S. Moffit, Scott Nolan, Melody Wen, Lori Hrdlicka, Duane A. Burnett, Matthew Gregory Bursavich, Gerhard Koenig, Don Costa, Holger Patzke, Raksha A. Acharya, Cuyue Tang, Hong Jin
Publikováno v:
Journal of medicinal chemistry. 64(19)
The recent approval of aducanumab for Alzheimer's disease has heightened the interest in therapies targeting the amyloid hypothesis. Our research has focused on identification of novel compounds to improve amyloid processing by modulating gamma secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f9b0147cc5066edcb7f9badfeea7b3
https://pubmed.ncbi.nlm.nih.gov/34550687
https://pubmed.ncbi.nlm.nih.gov/34550687
Autor:
Jean-Francois Blain, Judes Poirier
Publikováno v:
The Scientific World Journal, Vol 4, Pp 531-535 (2004)
This paper reviews recent literature on the role of lipoprotein lipase in the central nervous system with a focus on its recently described role in synaptic remodeling. This novel role could have implication for Alzheimer's disease treatment.
Externí odkaz:
https://doaj.org/article/617292d7697446989016f0314355d0b7
Autor:
James C. Lanter, Gerhard Koenig, Angela Y.-P. Chen, Toni Williamson, Jean-Francois Blain, Duane A. Burnett
Publikováno v:
Bioorganicmedicinal chemistry letters. 47
Phenotypic screening of an annotated small molecule library identified the quinuclidine tetrahydroisoquinoline solifenacin (1) as a robust enhancer of progranulin secretion with single digit micromolar potency in a murine microglial (BV-2) cell line.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3825c7beaa343c92e3d3fcaa88852a06
https://pubmed.ncbi.nlm.nih.gov/34153473
https://pubmed.ncbi.nlm.nih.gov/34153473
Autor:
Holger Patzke, Cuyue Tang, Gerhard Koenig, Hong Jin, Lori Hrdlicka, Duane A. Burnett, Sudarshan Kapadnis, Don Costa, Hilliary Hodgdon, Emily A. Freeman, Jean-Francois Blain, Jeffrey S. Moffit, Melody Wen, Bryce Alden Harrison, Matthew Gregory Bursavich, Raksha A. Acharya, Deirdre A. Murphy, Scott Nolan
Publikováno v:
Journal of medicinal chemistry. 60(6)
Herein we describe the design, synthesis, and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conformational restriction. Oxadiazine lead 47 possesses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9482321eb4d1ebfec5e8c96be975c48
https://pubmed.ncbi.nlm.nih.gov/28230986
https://pubmed.ncbi.nlm.nih.gov/28230986
Autor:
Holger Patzke, Lori Hrdlicka, Emily A. Freeman, Janusz Frackowiak, Marc Barshatzky, Pankaj Mehta, Jean-Francois Blain, Sangita P. Mehta, David Miller, Bruce A. Patrick, Jerzy Wegiel, Bozena Mazur-Kolecka
Publikováno v:
Journal of Alzheimer's disease : JAD. 57(1)
Secreted soluble amyloid-β 1-37 (Aβ37) peptide is one of the prominent Aβ forms next to Aβ40, and is found in cerebrospinal fluid (CSF) and blood. Recent studies have shown the importance of quantitation of CSF Aβ37 levels in combination with A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c310b6d437fad322e65eccfdc7daca5a
https://pubmed.ncbi.nlm.nih.gov/28222530
https://pubmed.ncbi.nlm.nih.gov/28222530
Autor:
Lori Hrdlicka, Hilliary Hodgdon, Emily A. Freeman, Holger Patzke, Cuyue Tang, Sudarshan Kapadnis, Gerhard Koenig, Deirdre A. Murphy, Ting Chen, Matthew Gregory Bursavich, Don E. Costa, Jean-Francois Blain, Duane A. Burnett, Scott Nolan, Harrison Bryce Alden, Zhiming Tu
Publikováno v:
Alzheimer's Research & Therapy
Background Familial Alzheimer’s disease (FAD) is caused by mutations in the amyloid precursor protein (APP) or presenilin (PS). Most PS mutations, which account for the majority of FAD cases, lead to an increased ratio of longer to shorter forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf86c9d8141f9dd9b2797ab755f3eaa
https://doi.org/10.1186/s13195-016-0199-5
https://doi.org/10.1186/s13195-016-0199-5
Publikováno v:
Journal of medicinal chemistry. 59(16)
The rapidly aging population desperately requires new therapies for Alzheimer's disease. Despite years of pharmaceutical research, limited clinical success has been realized, with several failed disease modification therapies in recent years. On the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d04138d7622452d9f80edd329774bc
https://pubmed.ncbi.nlm.nih.gov/27007185
https://pubmed.ncbi.nlm.nih.gov/27007185
Publikováno v:
Current Alzheimer Research. 5:33-37
Alzheimer's disease (AD) is a neurological disorder characterized by plaques and an elevated immune response. Specifically, increased expression of interleukin (IL)-1 and tumour necrosis factor (TNF)-alpha, has been observed in AD cerebrospinal fluid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c70df0e3de94554cb7d7d8bf646042
https://doi.org/10.2174/156720508783884666
https://doi.org/10.2174/156720508783884666
Publikováno v:
European Journal of Neuroscience. 24:1245-1251
Emerging evidences indicate a role for lipoprotein lipase (LPL) in degenerative states. Genetic variations in the LPL gene were previously associated to lipid imbalance and coronary artery disease (CAD) risk and severity, a condition that shares path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fcc9b79ee08e99eb66a8aecf48e83e
https://doi.org/10.1111/j.1460-9568.2006.05007.x
https://doi.org/10.1111/j.1460-9568.2006.05007.x