Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jean François Constant"'
In 2000, Ian McKay, a highly respected historian at Queen's University, published an article in the Canadian Historical Review entitled'The Liberal Order Framework: A Prospectus for a Reconnaissance of Canadian History.'Written to address a crisis in
Publikováno v:
AIMS Materials Science, Vol 2, Iss 4, Pp 473-483 (2015)
Ionizing radiations induce clustered damage sites known to be severely challenging for the cell's repair machinery. In the present study, we have grafted on a biochip four synthetic oligonucleotide duplexes containing either a single 8-oxoguanine, a
Externí odkaz:
https://doaj.org/article/97d7bb012ab142a59267099df63e5c2a
Publikováno v:
Biochemistry
Biochemistry, American Chemical Society, 2016, 55 (28), pp.3899-3906. ⟨10.1021/acs.biochem.6b00396⟩
Biochemistry, American Chemical Society, 2016, 55 (28), pp.3899-3906. ⟨10.1021/acs.biochem.6b00396⟩
Ionizing radiation, free radicals, and reactive oxygen species produce hundreds of different DNA lesions. Clustered lesions are typical for ionizing radiation. They compromise the efficiency of the base excision repair (BER) pathway, and as a consequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab8ca86d9399197f9ac22fc2292425
https://doi.org/10.1021/acs.biochem.6b00396
https://doi.org/10.1021/acs.biochem.6b00396
Publikováno v:
AIMS Materials Science, Vol 2, Iss 4, Pp 473-483 (2015)
AIMS Materials Science
AIMS Materials Science, AIMS Press, 2015, 2 (4), pp.473-483. ⟨10.3934/matersci.2015.4.473⟩
AIMS Materials Science, 2015, 2 (4), pp.473-483. ⟨10.3934/matersci.2015.4.473⟩
AIMS Materials Science
AIMS Materials Science, AIMS Press, 2015, 2 (4), pp.473-483. ⟨10.3934/matersci.2015.4.473⟩
AIMS Materials Science, 2015, 2 (4), pp.473-483. ⟨10.3934/matersci.2015.4.473⟩
Ionizing radiations induce clustered damage sites known to be severely challenging for the cell's repair machinery. In the present study, we have grafted on a biochip four synthetic oligonucleotide duplexes containing either a single 8-oxoguanine, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1ce96553f686d23f7c8aac04e60964
http://www.aimspress.com/Materials/article/514/fulltext.html
http://www.aimspress.com/Materials/article/514/fulltext.html
Publikováno v:
Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2014, 426 (7), pp.1524-1538. ⟨10.1016/j.jmb.2013.12.022⟩
Journal of Molecular Biology, Elsevier, 2014, 426 (7), pp.1524-1538. ⟨10.1016/j.jmb.2013.12.022⟩
International audience; Clustered DNA damage sites are caused by ionizing radiation. They are much more difficult to repair than are isolated single lesions, and their biological outcomes in terms of mutagenesis and repair inhibition are strongly dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac0d44b7ae20fea0bcf953f44221620
https://doi.org/10.1016/j.jmb.2013.12.022
https://doi.org/10.1016/j.jmb.2013.12.022
Autor:
Rémy Lartia, Jean-François Constant
Publikováno v:
Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2015, 80 (2), pp.705-710. ⟨10.1021/jo502170e⟩
Journal of Organic Chemistry, American Chemical Society, 2015, 80 (2), pp.705-710. ⟨10.1021/jo502170e⟩
Hydrogen atom abstraction from the C5′-position of nucleotides in DNA results in direct strand scission by generating alkali-labile fragments from the oxidized nucleotide. The major damage consists in a terminus containing a 5′-aldehyde as part o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357168f780f4ceae713e0161464d9ac7
https://hal.archives-ouvertes.fr/hal-01651416
https://hal.archives-ouvertes.fr/hal-01651416
Autor:
Olivier Lentzen, Stephan Schumm, Eric Defrancq, Jean-François Constant, Cécile Moucheron, Andrée Kirsch-De Mesmaeker, David García-Fresnadillo, Pascal Dumy
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 9:100-108
The influence of the distance between the an- choring site of the tethered (Ru(TAP)2dip) 2+ complex (TAP=1,4,5,8-tetraazaphenanthrene; dip=4,7-diphe- nyl-1,10-phenanthroline) on a probe sequence and the guanines of the complementary target strand was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75127f8c4a250e5ad2ecb143b0b3d0c0
https://doi.org/10.1007/s00775-003-0502-3
https://doi.org/10.1007/s00775-003-0502-3
Publikováno v:
Tetrahedron. 58:4291-4298
We describe the synthesis and DNA damaging activities of hybrid molecules in which a purine (adenine) is linked to an intercalating chromophore (acridine) by a polyamino linker. A DNA damaging agent, phenanthroline or para-nitrobenzamide, is tethered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7a849828a55611dd56780a7364e823
https://doi.org/10.1016/s0040-4020(02)00345-9
https://doi.org/10.1016/s0040-4020(02)00345-9
Autor:
Christian Coulombeau, Leila Ayadi, Damien Forget, Alain Martelli, Jean-François Constant, Martine Demeunynck
Publikováno v:
Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta). 104:284-289
We use molecular modeling calculations to study the structure and the flexibility of abasic (AP sites) and for the design of anticancer drugs targeted against AP sites. For either adenine or cytosine on the opposing strand within the same sequence co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262b370db0cb4e8626fe08add6aa08f0
https://doi.org/10.1007/s002140000140
https://doi.org/10.1007/s002140000140
Publikováno v:
Expert Opinion on Therapeutic Patents. 9:401-415
DNA repair is essential for cell survival by preventing the formation of mutations which can be lethal and in some cases at the origin of tumours. The DNA repair may occur directly by enzymatic removal of damage from the nucleobase or indirectly, ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625d5d4b0e50bfed42f4420fdc704594
https://doi.org/10.1517/13543776.9.4.401
https://doi.org/10.1517/13543776.9.4.401