Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jean François Bruxelle"'
Autor:
Jean-François Bruxelle, Tess Kirilenko, Nino Trattnig, Yiqiu Yang, Matteo Cattin, Paul Kosma, Ralph Pantophlet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM197-conjugate of a p
Externí odkaz:
https://doaj.org/article/6e82ed37f9564815b8027762ff199af6
Publikováno v:
Microorganisms, Vol 9, Iss 2, p 228 (2021)
Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after infection, which poses a major challenge for drug treatment and curative strategies. Many efforts are therefore focused on blocking infection. To this end, bo
Externí odkaz:
https://doaj.org/article/063bda00769d4030aa2b57352a8e213f
Autor:
Jean-François Bruxelle, Assaf Mizrahi, Sandra Hoÿs, Anne Collignon, Claire Janoir, Séverine Péchiné
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187212 (2017)
The immunogenicity of bacterial flagellin has been reported in different studies. By its close interaction with the immune system, the flagellin represents an interesting adjuvant and vaccine candidate. Salmonella Typhimurium flagellin has already be
Externí odkaz:
https://doaj.org/article/300a1fb783f849f092a45b3c59a7e084
Autor:
Tess Kirilenko, Jean-François Bruxelle, Nino Trattnig, Paul Kosma, Yiqiu Yang, Ralph Pantophlet, Matteo Cattin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM197-conjugate of a previously
Autor:
Kurtis Ng, Ralph Pantophlet, Matteo Cattin, Jean-François Bruxelle, Paul Kosma, Markus Blaukopf
Publikováno v:
Chembiochem
Oligomannose-type glycans on the spike protein of HIV-1 constitute relevant epitopes to elicit broadly neutralizing antibodies (bnAbs). Herein we describe an improved synthesis of α- and β-linked hepta- and nonamannosyl ligands that, subsequently,
Autor:
Quratulain Qureshi, Tess Kirilenko, Naiomi Lu, Paul Kosma, Nino Trattnig, Ralph Pantophlet, Jean-François Bruxelle
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Oligomannose-type glycans on HIV-1 gp120 form a patch that is targeted by several broadly neutralizing antibodies (bnAbs) and that therefore is of interest to vaccine design. However, attempts to elicit similar oligomannose-specific bnAbs by immunizi
Autor:
Nicholas J. Harmer, Andrea Kovacs-Simon, Séverine Péchiné, Claire Janoir, Jean François Bruxelle, William J. Bradshaw, K. Ravi Acharya, Stephen L. Michell
Publikováno v:
The Journal of Biological Chemistry
Clostridioides difficile is the primary cause of antibiotic-associated diarrhea and colitis, a healthcare-associated intestinal disease resulting in a significant fatality rate. Colonization of the gut is critical for C. difficile pathogenesis. The b
Publikováno v:
Anaerobe. 54:164-168
Clostridium difficile is a major cause of healthcare-associated diarrhea. SlpA is the precursor of the S-layer of C. difficile. The aim of this work was to evaluate the humoral immune response of hospitalized patients to SlpA and its potential role o
Publikováno v:
Microorganisms
Microorganisms, Vol 9, Iss 228, p 228 (2021)
Microorganisms, Vol 9, Iss 228, p 228 (2021)
Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after infection, which poses a major challenge for drug treatment and curative strategies. Many efforts are therefore focused on blocking infection. To this end, bo
Autor:
Nicolas Tsapis, Claire Janoir, Jean-François Bruxelle, Anne Collignon, Séverine Péchiné, Sandra Hoys, Elias Fattal
Publikováno v:
Vaccine
Vaccine, Elsevier, 2018, 36 (40), pp.6017-6021. ⟨10.1016/j.vaccine.2018.08.013⟩
Vaccine, Elsevier, 2018, 36 (40), pp.6017-6021. ⟨10.1016/j.vaccine.2018.08.013⟩
International audience; Clostridium difficile flagellin FliC is a highly immunogenic pathogen-associated molecular pattern playing a key role in C. difficile pathogenesis and gut colonization. Here, we designed an oral vaccine against C. difficile wi