Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Jean Fan"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Background Recent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted genes and their locations in fixed tissues. Normalization of gene expression data is often
Externí odkaz:
https://doaj.org/article/01f2c02da4014bcb949aa202a018ac3e
Autor:
Kaitlin M. Stouffer, Alain Trouvé, Laurent Younes, Michael Kunst, Lydia Ng, Hongkui Zeng, Manjari Anant, Jean Fan, Yongsoo Kim, Xiaoyin Chen, Mara Rue, Michael I. Miller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract This paper explicates a solution to building correspondences between molecular-scale transcriptomics and tissue-scale atlases. This problem arises in atlas construction and cross-specimen/technology alignment where specimens per emerging tec
Externí odkaz:
https://doaj.org/article/437796a99edd427faec35dd8a7032d20
Autor:
Kalen Clifton, Manjari Anant, Gohta Aihara, Lyla Atta, Osagie K. Aimiuwu, Justus M. Kebschull, Michael I. Miller, Daniel Tward, Jean Fan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Spatial transcriptomics (ST) technologies enable high throughput gene expression characterization within thin tissue sections. However, comparing spatial observations across sections, samples, and technologies remains challenging. To address
Externí odkaz:
https://doaj.org/article/74619ed8e49c4d0184bee33dbf658bc3
Autor:
Sepideh Gharaie, Kyungho Lee, Kathleen Noller, Emily K. Lo, Brendan Miller, Hyun Jun Jung, Andrea M. Newman-Rivera, Johanna T. Kurzhagen, Nirmish Singla, Paul A. Welling, Jean Fan, Patrick Cahan, Sanjeev Noel, Hamid Rabb
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract T cells are important in the pathogenesis of acute kidney injury (AKI), and TCR+CD4-CD8- (double negative-DN) are T cells that have regulatory properties. However, there is limited information on DN T cells compared to traditional CD4+ and C
Externí odkaz:
https://doaj.org/article/6ca1129e3f5c4b4882e9a4714dae46b0
Autor:
Jean Fan Yang, Wei Shi, Erica Wen Chen, Ben Nanfeng Luo, Jenny Zejun Zhao, Zhechen Yin, Jiaqi Tao
Publikováno v:
Frontiers in Psychology, Vol 14 (2023)
IntroductionOutsourcing, one of the nonstandard employment forms, has been increasingly popular with a wide variety of industries and employers. However, much less is known about its consequences at the employee level, especially relative to standard
Externí odkaz:
https://doaj.org/article/017f8e7c521b410ebea9e74400499b5f
Publikováno v:
Frontiers in Psychology, Vol 14 (2023)
Today, there is an increasingly aging workforce. Previous studies have examined whether aged people exhibit more positive attitudes, better health, and better performance. However, the relationship between age and proactive work behavior has seldom b
Externí odkaz:
https://doaj.org/article/33c9c20617ec4942a07573e6daa7a263
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Identifying cell-type-specific spatial patterns in ST data is critical for understanding tissue organization but current methods rely on external references. Here the authors develop a reference-free method to effectively recover cell-type transcript
Externí odkaz:
https://doaj.org/article/8169b376adb24eae99a8f90a6c88b8d9
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-5 (2021)
Spatially resolved transcriptomic data demand new computational analysis methods to derive biological insights. Here, we comment on these associated computational challenges as well as highlight the opportunities for standardized benchmarking metrics
Externí odkaz:
https://doaj.org/article/30b39018bedf4a9f9b290b200f3c9857
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1452-1465 (2020)
Cancer: analyzing the RNA of single cells By analyzing gene expression patterns in individual tumor cells, researchers can gain patient-specific insights that might inform more effective cancer treatment. Tumors are highly dynamic and heterogeneous c
Externí odkaz:
https://doaj.org/article/4fc938ab89fd4687afb48f26f083691c
Autor:
Cara Haymaker, Aung Naing, Shubham Pant, Minal Barve, Dae Won Kim, Richard Kim, Melissa Johnson, Marya Chaney, Robert Wolff, Jean Fan, Byung Ha Lee, NgocDiep Le, Sara Ferrando-Martinez, Hirva Mamdani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/1b86d5d524b24ac796db83a3f7cc63ce