Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Jean Emmanuel Hugonnet"'
Publikováno v:
eLife, Vol 12 (2024)
Peptidoglycan (PG) is a giant macromolecule that completely surrounds bacterial cells and prevents lysis in hypo-osmotic environments. This net-like macromolecule is made of glycan strands linked to each other by two types of transpeptidases that for
Externí odkaz:
https://doaj.org/article/bd8f2eb005d34429b81de0c595b3f4b7
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
β-lactam-induced bacterial killing is complex and not fully resolved. Authors carry out a genome-wide analysis, through penicillin-binding protein replacement, to identify genes essential for drug efficacy.
Externí odkaz:
https://doaj.org/article/cb6efd426f0747438396c3f0af0e152d
Autor:
Heiner Atze, Yucheng Liang, Jean-Emmanuel Hugonnet, Arnaud Gutierrez, Filippo Rusconi, Michel Arthur
Publikováno v:
eLife, Vol 11 (2022)
Antibiotics of the β-lactam (penicillin) family inactivate target enzymes called D,D-transpeptidases or penicillin-binding proteins (PBPs) that catalyze the last cross-linking step of peptidoglycan synthesis. The resulting net-like macromolecule is
Externí odkaz:
https://doaj.org/article/e5c5599d78da4893b7c68c3799c81221
Autor:
Nathanael A. Caveney, Guillermo Caballero, Henri Voedts, Ana Niciforovic, Liam J. Worrall, Marija Vuckovic, Matthieu Fonvielle, Jean-Emmanuel Hugonnet, Michel Arthur, Natalie C. J. Strynadka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In E. coli, alternate peptidoglycan crosslinking reactions carried out by the L,D-transpeptidase YcbB can lead to beta-lactam resistance. Here, Caveney et al. solve the crystal structure of YcbB and shed light into its mechanism of action and into Yc
Externí odkaz:
https://doaj.org/article/5893b624e29f4e1b9969ad99f17cd15a
Autor:
Landys Lopez Quezada, Robert Smith, Tania J. Lupoli, Zainab Edoo, Xiaojun Li, Ben Gold, Julia Roberts, Yan Ling, Sae Woong Park, Quyen Nguyen, Frank J. Schoenen, Kelin Li, Jean-Emmanuel Hugonnet, Michel Arthur, James C. Sacchettini, Carl Nathan, Jeffrey Aubé
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of Mycobacterium tuberculosis (Mtb) transpeptidases by carbap
Externí odkaz:
https://doaj.org/article/4d560f0f64cb40cc8c57181a0b7ea41e
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser
Externí odkaz:
https://doaj.org/article/830f94c5822143139769ccc31c458015
Autor:
Jeanne Malet-Villemagne, Liang Yucheng, Laurent Evanno, Sandrine Denis-Quanquin, Jean-Emmanuel Hugonnet, Michel Arthur, Claire Janoir, Thomas Candela
Publikováno v:
Microbiology Spectrum. 11
Cell wall glycopolymers (CWGPs) in Gram-positive bacteria have been reported to be involved in several bacterial processes. CWGP anchoring to peptidoglycan is important for growth and virulence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2609aee730672836a8debe720e310d4e
https://doi.org/10.1128/spectrum.04227-22
https://doi.org/10.1128/spectrum.04227-22
Autor:
Diana Panesso, Paul Planet, Lorena Diaz, Jean-Emmanuel Hugonnet, Truc T. Tran, Apurva Narechania, Jose M. Munita, Sandra Rincon, Lina P. Carvajal, Jinnethe Reyes, Alejandra Londoño, Hannah Smith, Robert Sebra, Gintaras Deikus, George M. Weinstock, Barbara E. Murray, Flavia Rossi, Michel Arthur, Cesar A. Arias
Publikováno v:
Emerging Infectious Diseases, Vol 21, Iss 10, Pp 1844-1848 (2015)
We report characterization of a methicillin-susceptible, vancomycin-resistant bloodstream isolate of Staphylococcus aureus recovered from a patient in Brazil. Emergence of vancomycin resistance in methicillin-susceptible S. aureus would indicate that
Externí odkaz:
https://doaj.org/article/46d944fe124a4f679afb5d66abde7092
Autor:
Jean-Emmanuel Hugonnet, Dominique Mengin-Lecreulx, Alejandro Monton, Tanneke den Blaauwen, Etienne Carbonnelle, Carole Veckerlé, Yves, V. Brun, Michael van Nieuwenhze, Christiane Bouchier, Kuyek Tu, Louis B Rice, Michel Arthur
Publikováno v:
eLife, Vol 5 (2016)
The target of β-lactam antibiotics is the D,D-transpeptidase activity of penicillin-binding proteins (PBPs) for synthesis of 4→3 cross-links in the peptidoglycan of bacterial cell walls. Unusual 3→3 cross-links formed by L,D-transpeptidases were
Externí odkaz:
https://doaj.org/article/c13d2d0e04b94f25b8075923cab7548f