Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Jean E. Merrill"'
Autor:
Jean E. Merrill
Publikováno v:
Immunobiology of Natural Killer Cells ISBN: 9780429288364
Immunologists face a thought-provoking question in considering natural killer (NK) cells and disease. NK cells activity probably plays no role as a mediator of antigen-associated killing or lymphokine production in such infections as malaria or toxop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582a814e0feb0396dfc0c69269fa9322
https://doi.org/10.1201/9780429288364-5
https://doi.org/10.1201/9780429288364-5
Autor:
Chelsea Dang, Pu Su-Fen, Kathleen McMonagle-Strucko, Susan E. Hanak, Brian Harvey, Deborah Iglesias-Bregna, Bin Zhu, Jinjun Liang, Jean E. Merrill
Publikováno v:
Journal of Neurology. 256:89-103
Teriflunomide is an orally available anti-inflammatory drug that prevents T and B cell proliferation and function by inhibition of dihydroorotate dehydrogenase. It is currently being developed for the treatment of multiple sclerosis (MS). We report h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7ef00c1d34a8d9c2d0fcfcc3907360
https://doi.org/10.1007/s00415-009-0075-3
https://doi.org/10.1007/s00415-009-0075-3
Autor:
Jean E Merrill
Publikováno v:
Neuropsychopharmacology
In making a selection of cellular tools and animal models for generating screening assays in the search for new drugs, one needs to take into consideration the practicality of their use in the drug discovery process. Conducting high-throughput primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6acafbf53623f1bb65f0f6dc40c19b2e
https://doi.org/10.1038/npp.2008.145
https://doi.org/10.1038/npp.2008.145
Autor:
Jean E. Merrill, Sean Murphy
Publikováno v:
Metabolic Brain Disease. 12:97-112
Reactive oxygen and nitrogen species function as direct and indirect modulators of gene expression through their interactions with transcription factors and also key enzymes in receptor-activated signalling pathways. This regulatory role may become d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c43566a74e4c437123bb35eab54a1d3f
https://doi.org/10.1007/bf02674732
https://doi.org/10.1007/bf02674732
Autor:
Joel C. Dopp, Allan MacKenzie-Graham, Charles J. Lowenstein, Louis J. Ignarro, Jeannette Griscavage, Jean E. Merrill, Sean Murphy, Branislava Mitrovic, Minzhen Ding
Publikováno v:
Journal of Neuroscience Research. 48:372-384
It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::384eb0c42eb71db65cd6db496fd5a9cf
https://doi.org/10.1002/(sici)1097-4547(19970515)48:4<372::aid-jnr9>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19970515)48:4<372::aid-jnr9>3.0.co
Autor:
Minzhen Ding, Joyce L. Wong, John Parkinson, Barbara A. St. Pierre, Louis J. Ignarro, Jean E. Merrill, Norma E. Rogers, Poonam Medberry
Publikováno v:
Journal of Biological Chemistry. 272:11327-11335
The understanding of the induction and regulation of inducible nitric-oxide synthase (iNOS) in human cells may be important in developing therapeutic interventions for inflammatory diseases. In the present study, we not only demonstrated that human f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f5c2155a1b0ef71d742aea1038dc62
https://doi.org/10.1074/jbc.272.17.11327
https://doi.org/10.1074/jbc.272.17.11327
Publikováno v:
Journal of Molecular Medicine. 75:174-186
During the past decade nitric oxide has emerged as an important mediator of physiological and pathophysiological processes. Elevated nitric oxide biosynthesis has been associated with nonspecific immune-mediated cellular cytotoxicity and the pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049a619e4fde13a79b3807e1fcb274de
https://doi.org/10.1007/s001090050102
https://doi.org/10.1007/s001090050102
Autor:
Etty N. Benveniste, Jean E. Merrill
Publikováno v:
Trends in Neurosciences. 19:331-338
Multiple sclerosis (MS) is thought to be an autoimmune disease. In healthy individuals, the T cells of the immune system, when activated by an infectious agent, regularly traffic across an intact blood-brain barrier, survey the CNS and then leave. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c2bbbaef6873114d7ba8850fa329ae
https://doi.org/10.1016/0166-2236(96)10047-3
https://doi.org/10.1016/0166-2236(96)10047-3
Autor:
Prasad S Koka, Jerome A. Zack, Jean E. Merrill, W. Peacock, Itzhak Fried, Scott G. Kitchen, Thanh V. Tran, Kongyuan He, S. S. Yashar
Publikováno v:
The Journal of Experimental Medicine
Although microglia are the only cells found to be productively infected in the central nervous system of acquired immunodeficiency disease syndrome (AIDS) patients, there is extensive white and gray matter disease nonetheless. This neuropathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38175e3c528c84992b0983db620816c
https://doi.org/10.1084/jem.182.4.941
https://doi.org/10.1084/jem.182.4.941
Autor:
Jean E. Merrill, G M Jonakait
Publikováno v:
The FASEB Journal. 9:611-618
Neurotransmitters, neuropeptides, neurotrophins, and neuroendocrine hormones have traditionally been assigned functions in normal development and homeostasis of neuronal networks; cytokines and adhesion molecules have been assigned functions within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72b5fdf12a27f6847d38575d0b919f74
https://doi.org/10.1096/fasebj.9.8.7768352
https://doi.org/10.1096/fasebj.9.8.7768352