Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Jean E. Lachowicz"'
Autor:
Jean E. Lachowicz, Jean-Paul Castaigne, Borhane Annabi, Mustapha Iddir, Jean-Christophe Currie, Simon Lord-Dufour, Sasmita Tripathy, Michel Demeule, Anthony Regina
A. Confirmation of HER2-positive expression status of BT-474 and SKBR3 cells and HER2-negative status of MCF-7, U-87 and HBMEC cells by WB analysis using an anti-HER2 mAb. B. Immunodetection of LRP1 by WB using an antibody directed against the 85 kDa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaab8dbb02b6e6fc7dc6acfdbf2b914
https://doi.org/10.1158/1535-7163.22502209.v1
https://doi.org/10.1158/1535-7163.22502209.v1
Autor:
Jean E. Lachowicz, Jean-Paul Castaigne, Borhane Annabi, Mustapha Iddir, Jean-Christophe Currie, Simon Lord-Dufour, Sasmita Tripathy, Michel Demeule, Anthony Regina
A. In vitro binding of ANG4043 and Anti-HER2 mAb to the HER2/Fc chimera protein. B, C. Lack of effect of ANG4043 and Anti-HER2 on the proliferation of HER2-negative MCF-7 (B) and U-87 (C) cells using the [3H] thymidine incorporation assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7197983afa761dcae6f1e699123d51e
https://doi.org/10.1158/1535-7163.22502203.v1
https://doi.org/10.1158/1535-7163.22502203.v1
Autor:
Jean E. Lachowicz, Jean-Paul Castaigne, Borhane Annabi, Mustapha Iddir, Jean-Christophe Currie, Simon Lord-Dufour, Sasmita Tripathy, Michel Demeule, Anthony Regina
Legends to supplemental figures 1-4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676c61c35c3826af61b6be52509ac9da
https://doi.org/10.1158/1535-7163.22502197.v1
https://doi.org/10.1158/1535-7163.22502197.v1
Autor:
Borhane Annabi, Jean-Paul Castaigne, Mustapha Iddir, Anthony Regina, Sasmita Tripathy, Jean E. Lachowicz, Jean-Christophe Currie, Simon Lord-Dufour, Michel Demeule
Publikováno v:
Molecular Cancer Therapeutics. 14:129-140
Anti-HER2 monoclonal antibodies (mAb) have been shown to reduce tumor size and increase survival in patients with breast cancer, but they are ineffective against brain metastases due to poor brain penetration. In previous studies, we identified a pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3443f471f2cfe8e024f223a82e019919
https://doi.org/10.1158/1535-7163.mct-14-0399
https://doi.org/10.1158/1535-7163.mct-14-0399
Autor:
Jean E. Lachowicz, Kung-I Feng, Joyce J. Hwa, Jitendra D. Belani, Michael Wong, Ling Kang, Diane Grotz, Wensheng Yu, Sue-Ing Lin, Yang Cao, Andrew Stamford, Richard A. Morrison, Peishan Lin, Duane E. DeMong, Hongtao Zhang, Peng Dai, Jolicia Gauuan, Christopher Sondey, Joseph A. Kozlowski, He Zhao, Mark Liang, Ying Zhai, Brian J. Lavey, Xing Dai, Aileen Soriano, Tao Meng, Ping Chen, De-Yi Yang, William J. Greenlee, Bradley Prudence K, Kathleen Cox, Bhuneshwari Patel, Paul McNamara, Jesse K. Wong, Michael W. Miller, Guowei Zhou, Teresa Andreani
Publikováno v:
Journal of Medicinal Chemistry. 57:2601-2610
A novel series of spiroimidazolone-based antagonists of the human glucagon receptor (hGCGR) has been developed. Our efforts have led to compound 1, N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d79521da6469de081b15fb4cf46d71d
https://doi.org/10.1021/jm401858f
https://doi.org/10.1021/jm401858f
Autor:
Élie Besserer-Offroy, Karine Belleville, Jean-Michel Longpré, Alain Larocque, Eric Marsault, Anthony Regina, Jean-Paul Castaigne, Philippe Sarret, Alexandre Murza, Carine Thiot, Michel Demeule, Christian Che, Nicolas Beaudet, Richard Béliveau, Jean E. Lachowicz, Pascal Tétreault, Steven L. Gonias, Richard Leduc
Publikováno v:
The Journal of clinical investigation, vol 124, iss 3
Neurotensin (NT) has emerged as an important modulator of nociceptive transmission and exerts its biological effects through interactions with 2 distinct GPCRs, NTS1 and NTS2. NT provides strong analgesia when administered directly into the brain; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c293c73cf29acd515afffe7cc34cc904
https://doi.org/10.1172/jci70647
https://doi.org/10.1172/jci70647
Publikováno v:
Cancer Research. 73:P6-11
Background: Treatment options for metastatic brain tumors originating from HER2-positive breast disease are limited due to the inability of most anti-tumor agents to enter the brain. While the selectively permeable blood-brain barrier (BBB) restricts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0665239857ef759159576aa0ed35fc5e
https://doi.org/10.1158/0008-5472.sabcs13-p6-11-05
https://doi.org/10.1158/0008-5472.sabcs13-p6-11-05
Autor:
Margaret van Heek, Joe F. Lee, Michelle Smith, Mingxiang Lin, Nicolas Zorn, John R. Cook, Robert G. Aslanian, Pauline C. Ting, Scott S. Walker, Hyunjin M. Kim, Jean E. Lachowicz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:985-988
The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edf659511326af3e6cd0cafaa432ead
https://doi.org/10.1016/j.bmcl.2012.12.040
https://doi.org/10.1016/j.bmcl.2012.12.040
Autor:
Jean E. Lachowicz, Geoffrey B. Varty, Robert J. Naylor, Guy A. Higgins, Eric M. Parker, Cynthia A. Morgan, Ruth A. Duffy
Publikováno v:
Pharmacology Biochemistry and Behavior. 102:95-100
NK1 receptor antagonists have been shown to have a variety of physiological and potential therapeutic effects in animal models and in humans. The present studies demonstrate that Rolapitant (SCH 619734, (5S)-8(S)-[[1(R)-[3,5 bis(trifluoromethyl)pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28e3b293969e6ef53f92a6d13634048
https://doi.org/10.1016/j.pbb.2012.03.021
https://doi.org/10.1016/j.pbb.2012.03.021
Autor:
Haiqun Tang, Robert Mazzola, Duane A. Burnett, William J. Greenlee, Jean E. Lachowicz, Hongtao Zhang, Yuanzan Ye, Michelle Smith, Ahmad Fawzi, Zhaoning Zhu, Jing Su, Li Qiang, Mckittrick Brian A, T.K. Sasikumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:836-840
A series of novel dopamine D(1) antagonists derived from functionalization of the D-ring of SCH 39166 were prepared. A number of these compounds displayed subnanomolar D(1) activity and more than 1000-fold selectivity over D(2). We found C-3 derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d019dacb2a7c725ab3c978b6558861
https://doi.org/10.1016/j.bmcl.2009.12.100
https://doi.org/10.1016/j.bmcl.2009.12.100