Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark

Autor: Marion Crespo, Lacey J. Luense, Marie Arlotto, Jialei Hu, Jean Dorsey, Encar García-Oliver, Parisha P. Shah, Delphine Pflieger, Shelley L. Berger, Jérôme Govin

Publikováno v: Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-23 (2020)

Abstract Background Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly compacted chromatin org

Externí odkaz: https://doaj.org/article/63b9cbeb712f42c1b2b96fe0dd57f7a0

Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark

Autor: Parisha P. Shah, Lacey J. Luense, Marie Arlotto, Encar García-Oliver, Shelley L. Berger, Jialei Hu, Jean Dorsey, Delphine Pflieger, Marion Crespo, Jérôme Govin

Publikováno v: Epigenetics & Chromatin
Epigenetics & Chromatin, BioMed Central, 2020, 13 (1), ⟨10.1186/s13072-020-00349-5⟩
Epigenetics & Chromatin, 2020, 13 (1), ⟨10.1186/s13072-020-00349-5⟩
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-23 (2020)

International audience; Background: Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly compact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb841e8f71a57ad6cf70aba6822658b4
https://hal.archives-ouvertes.fr/hal-02945586

Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae

Autor: Jérôme Govin, Jonathan Schug, Jean Dorsey, Shelley L. Berger, Saadi Khochbin, Thanuja Krishnamoorthy

Publikováno v: Nucleic Acids Research

We previously showed that histone H4 serine-1 phosphorylation (H4S1ph) is evolutionarily conserved during gametogenesis, and contributes to post-meiotic nuclear compaction and to full completion of sporulation in the yeast Saccharomyces cerevisiae. P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912965f300a55f510eb5f02a9fc5edb4
https://doi.org/10.1093/nar/gkq218

The Histone Variant H3.3 Regulates Gene Expression during Lytic Infection with Herpes Simplex Virus Type 1

Autor: Lyndi M. Rice, Brandon J. Placek, Nigel W. Fraser, Jean Dorsey, Shelley L. Berger, Jing Huang, Jennifer R. Kent

Publikováno v: Journal of Virology. 83:1416-1421

It has been proposed that incorporation of the histone variant H3.3 within actively transcribed regions of a genome helps to facilitate transcription. In this report we use lytic infection by herpes simplex virus type 1 (HSV-1) as a model to examine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed06e676ddf694965eb5e16e61fefb7
https://doi.org/10.1128/jvi.01276-08

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

Autor: Kajia Cao, Greg Donahue, Chong He, Weiwei Dang, Daniel T. Carr, Jun Yeop Lee, Rocco Perry, Shelley L. Berger, Junbiao Dai, Brian M. Wasko, Matt Kaeberlein, Brian D. Gregory, Jef D. Boeke, Wei Liu, John D. Wagner, Brett Robison, Brian K. Kennedy, Jean Dorsey, Xiaohua Cao, Payel Sen

Publikováno v: Genesdevelopment. 29(13)

Epigenetic mechanisms, including histone post-translational modifications, control longevity in diverse organisms. Relatedly, loss of proper transcriptional regulation on a global scale is an emerging phenomenon of shortened life span, but the specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd437a60d61a941a49a1f3e4717c11ff
https://pubmed.ncbi.nlm.nih.gov/26159996