Výsledky vyhledávání - "Jean Descarpentrie"

Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors

Autor: Jean Descarpentrie, Marcos J. Araúzo-Bravo, Zongsheng He, Alexia François, Álvaro González, Patricia Garcia-Gallastegi, Iker Badiola, Serge Evrard, Simon Pernot, John W. M. Creemers, Abdel-Majid Khatib

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
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Cancers; Volume 14; Issue 5; Pages: 1195

Proprotein convertases or PCs are known to regulate the malignant phenotype of colon cancer cells by different mechanisms, but their effects on cancer stem cells (CSCs) have been less widely investigated. Here, we report that PCs expression is altere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b739c3688101b7f8ce79a7ceb98f00ff
http://hdl.handle.net/10810/55918

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Furin prodomain ppfurin enhances ca2+ entry through orai and trpc6 channels’ activation in breast cancer cells

Autor: Jose J. Lopez, Iker Badiola, Juan A. Rosado, Simon Pernot, Fabienne Soulet, Geraldine Siegfried, Tarik Smani, Carlos Cantonero, Jean Descarpentrie, Serge Evrard, Abdel-Majid Khatib

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Cancers, Vol 13, Iss 1670, p 1670 (2021)
Addi. Archivo Digital para la Docencia y la Investigación
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
Cancers
Volume 13
Issue 7
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco

This article belongs to the Special Issue Calcium Signaling Remodeling and Functional Role in Cancer Cells
[Simple Summary] Furin, a proprotein convertase that belongs to a family of Ca2+-dependent serine peptidases, is involved in the maturatio

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Proprotein convertases blockage up-regulates specifically metallothioneins coding genes in human colon cancer stem cells

Autor: Jean Descarpentrie, Daniela Gerovska, Olatz Crende, Marcos J. Araúzo-Bravo, Jokin Eguia, María Casado-Andrés, Ander Martin, Iker Badiola, Abdel-Majid Khatib, Patricia Garcia-Gallastegi

Publikováno v: Biochimica et Biophysica Acta (BBA)-Molecular Cell Research

Despite continuous exertion made, colon cancer still represents a major health problem and its incidence continues being high worldwide. There is growing evidence in support of the cancer stem cells (CSCs) being central in the initiation of this canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda12457c7695210089f49b268627c99

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Furin Prodomain Ppfurin Enhances Soce Through trpc6 Activation in Breast Cancer Cells

Autor: Tarik Smani, Carlos Cantonero, Jose J. Lopez, Jean Descarpentrie, Serge Evrard, Juan A. Rosado, Iker Badiola, Geraldine Siegfried, Simon Pernot, Abdel-Majid Khatib

The intracellular calcium concentration ([Ca2+]i) modulation plays a key role in the regulation of cellular growth and survival in normal cells and failure of [Ca2+]i homeostasis is involved in tumor initiation and progression. Here we show that inhi

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ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation

Autor: Abdel-Majid Khatib, Jean Descarpentrie, Malaurie Eugenie, Amandine Mouchard, Juan A. Rosado, Mercedes Tomé, Isabelle Soubeyran, Jean-Luc Hoepffner, Isabel D. Alves, Macha Nikolski, Jose J. Lopez, Raúl V. Durán, Serge Evrard, Marielle Dubreuil, Geraldine Siegfried, Bruno O. Villoutreix, Katarzyna B. Hooks, Clément Bodineau, Fabienne Soulet

Publikováno v: JCI Insight
JCI Insight, 2020, 5 (14), ⟨10.1172/jci.insight.129070⟩
JCI Insight, American Society for Clinical Investigation, 2020, 5 (14), ⟨10.1172/jci.insight.129070⟩
Digital.CSIC. Repositorio Institucional del CSIC
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Apelin is a well-established mediator of survival and mitogenic signaling through the apelin receptor (Aplnr) and has been implicated in various cancers; however, little is known regarding Elabela (ELA/APELA) signaling, also mediated by Aplnr, and it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdd9248a3668343124571d0ad2fbbae
https://doi.org/10.1172/jci.insight.129070

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Proprotein convertases: Key players in inflammation-related malignancies and metastasis

Autor: Geraldine Siegfried, Abdel-Majid Khatib, Serge Evrard, Jean Descarpentrie

Publikováno v: Cancer Letters
Cancer Letters, Elsevier, 2020, 473, pp.50-61. ⟨10.1016/j.canlet.2019.12.027⟩
Cancer Letters, 2020, 473, pp.50-61. ⟨10.1016/j.canlet.2019.12.027⟩

Many cancers occur from locations of inflammation due to chronic irritation and/or infection. Tumor microenvironment contains various different inflammatory cells and mediators that orchestrate diverse neoplastic processes, including proliferation, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906c6278f6a401eb110043b1c05228b4
https://hal.archives-ouvertes.fr/hal-03489777

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Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors

Autor: 'Jean Descarpentrie

Publikováno v: Marcos J. Araúzo-Bravo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::7cfad334a11563291434727e787b57bd

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