Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jean D Beggs"'
Publikováno v:
RNA Biology, Vol 16, Iss 12, Pp 1775-1784 (2024)
Pre-messenger RNA splicing involves multi-step assembly of the large spliceosome complexes that catalyse the two consecutive trans-esterification reactions, resulting in intron removal. There is evidence that proof-reading mechanisms monitor the fide
Externí odkaz:
https://doaj.org/article/fe41cc9df50f45d7853c0dfdf966cbe4
Autor:
Laura Milligan, Camille Sayou, Alex Tuck, Tatsiana Auchynnikava, Jane EA Reid, Ross Alexander, Flavia de Lima Alves, Robin Allshire, Christos Spanos, Juri Rappsilber, Jean D Beggs, Grzegorz Kudla, David Tollervey
Publikováno v:
eLife, Vol 6 (2017)
Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with slowed RNAPII elongation. Here, we identify a site of ubiquitination (K1246) in the cataly
Externí odkaz:
https://doaj.org/article/6886fc31ae9046db907f472fc2fe812b
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002215 (2011)
Messenger RNA splicing is an essential and complex process for the removal of intron sequences. Whereas the composition of the splicing machinery is mostly known, the kinetics of splicing, the catalytic activity of splicing factors and the interdepen
Externí odkaz:
https://doaj.org/article/ab4f106c25b3492fb8cc3da805ade245
Autor:
Stuart Aitken, Marie-Cécile Robert, Ross D Alexander, Igor Goryanin, Edouard Bertrand, Jean D Beggs
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8845 (2010)
The complexity of messenger RNA processing is now being uncovered by experimental techniques that are capable of detecting individual copies of mRNA in cells, and by quantitative real-time observations that reveal the kinetics. This processing is com
Externí odkaz:
https://doaj.org/article/28c59f088b4c4ab4b40d642dacf416ad
Autor:
Lucia C. Strader, Max V. Staller, Anne E. Willis, Geoffrey J. Faulkner, Jean D. Beggs, Thomas R. Cech
Publikováno v:
Molecular Cell. 83:320-323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1219fe3573fd14f219c3c8c94554b1b
https://doi.org/10.1016/j.molcel.2023.01.002
https://doi.org/10.1016/j.molcel.2023.01.002
Autor:
Isabella E. Maudlin, Jean D. Beggs
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
From yeast to humans, pre-mRNA splicing occurs mainly co-transcriptionally, with splicing and transcription functionally coupled such that they influence one another. The recruitment model of co-transcriptional splicing proposes that core members of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4dbc409db442bfa2ef63d422b6baea
https://doi.org/10.1080/15476286.2021.1991673
https://doi.org/10.1080/15476286.2021.1991673
Publikováno v:
Mendoza ochoa, G, Barrass, J, Maudlin, I & Beggs, J 2019, ' Blocking late stages of splicing quickly limits pre-spliceosome assembly in vivo ', Rna biology . https://doi.org/10.1080/15476286.2019.1657788
RNA Biology
RNA Biology
Pre-messenger RNA splicing involves multi-step assembly of the large spliceosome complexes that catalyse the two consecutive trans-esterification reactions, resulting in intron removal. There is evidence that proof-reading mechanisms monitor the fide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04713d11e26e323785483db0b2b76b7c
https://doi.org/10.1080/15476286.2019.1657788
https://doi.org/10.1080/15476286.2019.1657788
Autor:
Vahid Aslanzadeh, Jean D. Beggs
Publikováno v:
RNA
We reported previously that, in budding yeast, transcription rate affects both the efficiency and fidelity of pre-mRNA splicing, especially of ribosomal protein transcripts. Here, we report that the majority of ribosomal protein transcripts with non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0745a55fec56ca6e13e908726cf623
https://pubmed.ncbi.nlm.nih.gov/32439718
https://pubmed.ncbi.nlm.nih.gov/32439718
Autor:
J David, Barrass, Jean D, Beggs
Publikováno v:
Journal of visualized experiments : JoVE. (150)
The nucleotide analogue, 4-thiouracil (4tU), is readily taken up by cells and incorporated into RNA as it is transcribed in vivo, allowing isolation of the RNA produced during a brief period of labelling. This is done by attaching a biotin moiety to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e92f073525c793c191dfe3fe90146ac7
https://pubmed.ncbi.nlm.nih.gov/31498317
https://pubmed.ncbi.nlm.nih.gov/31498317
Autor:
Jean D. Beggs, J. David Barrass
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9507ca64d4f24da23a832fafe169d820
https://doi.org/10.3791/59952-v
https://doi.org/10.3791/59952-v