Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jean Claude Sari"'
Publikováno v:
Biochimica et biophysica acta. 1207(1)
The thermodynamic parameters of the binding of some folate analogues (methotrexate, trimetrexate and trimethoprim) to dihydrofolate reductases from different species have been measured with a flow microcalorimetric method at 37°C. In the absence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7085768ab4b0722d193d6f9860a065b
https://pubmed.ncbi.nlm.nih.gov/8043612
https://pubmed.ncbi.nlm.nih.gov/8043612
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461362876
Dihydrofolate reductase (DHFR) is the target of numerous folate analogues including the antibacterial agent Trimethoprim (TMP), the anticancer agent Methotrexate (MTX), and a second generation antifolate compound, Trimetrexate (TMQ).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80913359fa2316a6a33f3d9e3b0506d
https://doi.org/10.1007/978-1-4615-2960-6_105
https://doi.org/10.1007/978-1-4615-2960-6_105
Publikováno v:
European Journal of Biochemistry
European Journal of Biochemistry, Wiley, 1991, 201, pp.217-222
European Journal of Biochemistry, Wiley, 1991, 201, pp.217-222
A complete microcalorimetric investigation of the interactions between the native subunits of the bovine pancreatic procarboxypeptidase A-S6 ternary complex has been performed. All the association constants and thermodynamic parameters associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d516d953db064f1ef5f7c9b1f947272
https://pubmed.ncbi.nlm.nih.gov/1915366
https://pubmed.ncbi.nlm.nih.gov/1915366
Publikováno v:
Biochemical pharmacology. 40(10)
A microcalorimetric method was used for the direct study of the interaction of methotrexate, its metabolites, and new antifolates N10-propargyl-5,8-dideazafolate (CB 3717) and 2-methyl,2-desamino N10-propargyl-5,8-dideazafolate (CB 3819), with thymid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5641efa456df1866ea80cfd5b310787
https://pubmed.ncbi.nlm.nih.gov/2244925
https://pubmed.ncbi.nlm.nih.gov/2244925
Autor:
Anne-Marie Chauvet-Monges, Aimé Crevat, Jean-Pierre Belaich, J. P. Monti, Jean-Claude Sari, Christian Gaudin
Publikováno v:
Journal de Chimie Physique. 76:714-719
Une des proteines periplasmiques affines isolee a partir de Escherichia Coli a la propriete de reconnaitre les acides amines a chaine laterale : Leucine, Isoleucine, Valine, Threonine. Les auteurs ont etudie par RMN du proton le comportement de ces s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97e6882dca70e041201399c4726c011d
https://doi.org/10.1051/jcp/1979760714
https://doi.org/10.1051/jcp/1979760714
Publikováno v:
Journal of Bioenergetics and Biomembranes. 14:171-179
Using an original microcalorimetric method, the existence of the Mg2ATP ternary chelate has been studied. The thermodynamic parameters of this complex are delta H = 7.2 +/- 0.5 kJ mole-1 and K = 49 +/- 9 M-1. These values are compared with those prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caaf6ca1257d4f186b5bdb599115aa7
https://doi.org/10.1007/bf00745018
https://doi.org/10.1007/bf00745018
Publikováno v:
Biochimie. 60:353-359
Resume Un modele mathematique est propose qui explique quelques cas de saturations biphasiques des proteines affines par leurs substrats par l'effet d'une inhibition competitive. L'inhibiteur peut etre le substrat lui-meme en particulier lorsque le p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b29f1f51a8da938d167e68b5faebaf
https://doi.org/10.1016/s0300-9084(78)80668-3
https://doi.org/10.1016/s0300-9084(78)80668-3
Publikováno v:
Analytical Biochemistry. 165:341-348
A flow microcalorimetric method was developed for the analysis of enzymatic activities in crude tissue homogenates. It can be applied whenever a heat exchange is involved in an enzymatic reaction. The consequent sensitivity obviously depends on the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc9a6d667fa5a94a95bc576345ac205
https://doi.org/10.1016/0003-2697(87)90279-x
https://doi.org/10.1016/0003-2697(87)90279-x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 964:53-60
Interaction of methotrexate and some of its metabolites with a mammalian dihydrofolate reductase was studied using two complementary methods, potentiometry and microcalorimetry. The major plasma metabolite of this anticancer agent, 7-hydroxymethotrex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1383ac77b67ceedec1725b8c240c2aec
https://doi.org/10.1016/0304-4165(88)90066-9
https://doi.org/10.1016/0304-4165(88)90066-9
Publikováno v:
Analytical Biochemistry. 152:1-5
A pH-Stat titration method was developed for measuring dihydrofolate reductase (DHFR) activity; this method permits detection of very low DHFR activities corresponding to 100 pmol of substrate reduced per minute. This value is about ten times lower t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8374fd8295815c3c67c97d3df516f630
https://doi.org/10.1016/0003-2697(86)90110-7
https://doi.org/10.1016/0003-2697(86)90110-7