Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jean Claude Ortuno"'
Autor:
Stéphane Depil, Francisco H. Cruzalegui, John A. Hickman, Alain Pierré, Jean-Claude Ortuno, Alex Cordi, Jean A. Boutin, Brian P. Lockhart, Paolo M. Comoglio, Anne Jacquet-Bescond, Valérie Cattan, François Bouzom, Georges Da Violante, Gilles Ferry, Stéphane Léonce, Alain Bruno, Imre Fejes, Carine Saunier, Céline J. Bossard, Mike F. Burbridge
Pharmacokinetic parameters of S49076 administered orally to female balb/c nu/nu mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d85780489a7d5f2f98bfaf00e0d717
https://doi.org/10.1158/1535-7163.22500580.v1
https://doi.org/10.1158/1535-7163.22500580.v1
Autor:
Stéphane Depil, Francisco H. Cruzalegui, John A. Hickman, Alain Pierré, Jean-Claude Ortuno, Alex Cordi, Jean A. Boutin, Brian P. Lockhart, Paolo M. Comoglio, Anne Jacquet-Bescond, Valérie Cattan, François Bouzom, Georges Da Violante, Gilles Ferry, Stéphane Léonce, Alain Bruno, Imre Fejes, Carine Saunier, Céline J. Bossard, Mike F. Burbridge
Aberrant activity of the receptor tyrosine kinases MET, AXL, and FGFR1/2/3 has been associated with tumor progression in a wide variety of human malignancies, notably in instances of primary or acquired resistance to existing or emerging anticancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430099b575997bc84c21ebae598114d2
https://doi.org/10.1158/1535-7163.c.6536506.v1
https://doi.org/10.1158/1535-7163.c.6536506.v1
Autor:
Stéphane Depil, Francisco H. Cruzalegui, John A. Hickman, Alain Pierré, Jean-Claude Ortuno, Alex Cordi, Jean A. Boutin, Brian P. Lockhart, Paolo M. Comoglio, Anne Jacquet-Bescond, Valérie Cattan, François Bouzom, Georges Da Violante, Gilles Ferry, Stéphane Léonce, Alain Bruno, Imre Fejes, Carine Saunier, Céline J. Bossard, Mike F. Burbridge
Western blot detection of total and phosphorylated MET, AXL, FGFR1/2/3 and phosphorylated FRS2 in cell lines and tumor xenografts used in the study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123135a315fe10245d8747481cf1d27a
https://doi.org/10.1158/1535-7163.22500589
https://doi.org/10.1158/1535-7163.22500589
Autor:
Stéphane Depil, Francisco H. Cruzalegui, John A. Hickman, Alain Pierré, Jean-Claude Ortuno, Alex Cordi, Jean A. Boutin, Brian P. Lockhart, Paolo M. Comoglio, Anne Jacquet-Bescond, Valérie Cattan, François Bouzom, Georges Da Violante, Gilles Ferry, Stéphane Léonce, Alain Bruno, Imre Fejes, Carine Saunier, Céline J. Bossard, Mike F. Burbridge
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2531d2864ca4243b46130be353d490da
https://doi.org/10.1158/1535-7163.22500592.v1
https://doi.org/10.1158/1535-7163.22500592.v1
Autor:
Stéphane Depil, Francisco H. Cruzalegui, John A. Hickman, Alain Pierré, Jean-Claude Ortuno, Alex Cordi, Jean A. Boutin, Brian P. Lockhart, Paolo M. Comoglio, Anne Jacquet-Bescond, Valérie Cattan, François Bouzom, Georges Da Violante, Gilles Ferry, Stéphane Léonce, Alain Bruno, Imre Fejes, Carine Saunier, Céline J. Bossard, Mike F. Burbridge
Kinase interaction map for S49076 at 100 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205dbfd47ef91e9858162252f06c4b82
https://doi.org/10.1158/1535-7163.22500586
https://doi.org/10.1158/1535-7163.22500586
Autor:
Céline Legros, Anne Rojas, Clémence Dupré, Chantal Brasseur, Isabelle Riest‐Fery, Olivier Muller, Jean‐Claude Ortuno, Olivier Nosjean, Sophie‐Pénélope Guenin, Gilles Ferry, Jean A. Boutin
Publikováno v:
Protein Science. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7585e91b40eb6f6fad9ab4d81cab0b
https://doi.org/10.1002/pro.4459
https://doi.org/10.1002/pro.4459
Autor:
Céline, Legros, Anne, Rojas, Clémence, Dupré, Chantal, Brasseur, Isabelle, Riest-Fery, Olivier, Muller, Jean-Claude, Ortuno, Olivier, Nosjean, Sophie-Pénélope, Guenin, Gilles, Ferry, Jean A, Boutin
Publikováno v:
Protein science : a publication of the Protein Society. 31(12)
D3/D2 sub-specificity is a complex problem to solve. Indeed, in the absence of easy structural biology of the G-protein coupled receptors, and despite key progresses in this area, the systematic knowledge of the ligand/receptor relationship is diffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc1121ec1d7b67bf067023180e1d39df
https://pubmed.ncbi.nlm.nih.gov/36177735
https://pubmed.ncbi.nlm.nih.gov/36177735
Autor:
Millan Mark, Stephen Hanessian, Oscar Mario Saavedra, Jean-Claude Ortuno, Delphine Dupuis, Arnaud Gohier, Clotilde Mannoury la Cour, Anne Rojas, Dominique Brossard, Delphine Karila
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:38-52
All clinically-used antipsychotics display similar affinity for both D2 (D2R) and D3 (D3R) receptors, and they likewise act as 5-HT2A receptor antagonists. They provide therapeutic benefit for positive symptoms, but no marked or consistent improvemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b2e9933b4136694c252b0a9208bf634
https://doi.org/10.1016/j.bmc.2016.10.010
https://doi.org/10.1016/j.bmc.2016.10.010
Autor:
Véronique Michelet, Jérôme Starck, Clément F. Heinrich, Eder Tomás-Mendivil, Jean-Claude Ortuno
Publikováno v:
ResearcherID
The gold-catalyzed domino cyclization/nucleophilic reaction of ortho-carbonylalkynylaryls has been studied. Thus, 2-(pyridin-2-ylethynyl)benzaldehyde has been chosen to isolate key intermediates that may take part in the reaction mechanism. Employing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076f6017f519bb8ef07a86c9dd055e06
https://doi.org/10.1021/acscatal.6b02636
https://doi.org/10.1021/acscatal.6b02636
Autor:
David M. Watson, Mauricette Brocco, Kevin C. F. Fone, Anne Dekeyne, Clotilde Mannoury la Cour, Jean-Claude Ortuno, Millan Mark, Alain P. Gobert
Publikováno v:
Neuropharmacology. 177:108099
© 2020 Elsevier Ltd To date, there are no interventions that impede the inexorable progression of Alzheimer's disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N-Methyl-D-Aspartate receptor antagonist, memantine, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af770005d941744e5545396b4dd1763
https://doi.org/10.1016/j.neuropharm.2020.108099
https://doi.org/10.1016/j.neuropharm.2020.108099