Genotoxicity of styrene-7,8-oxide and styrene in Fisher 344 rats: A 4-week inhalation study

Autor: Yves Guichard, Cristina Langlais, Hervé Nunge, Frédéric Cosnier, Jean-Claude Micillino, Stéphane Binet, Sylvie Sébillaud, Laurent Gate, Christian Darne

Publikováno v: Toxicology Letters. 211:211-219

The cytogenetic alterations in leukocytes and the increased risk for leukemia, lymphoma, or all lymphohematopoietic cancer observed in workers occupationally exposed to styrene have been associated with its hepatic metabolisation into styrene-7,8-oxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faab1c36ec50d07c5b4b296aee29efc9
https://doi.org/10.1016/j.toxlet.2012.03.796

Genotoxic effects of bitumen fumes in Big Blue® transgenic rat lung

Autor: Bertrand Rihn, G. Morel, Laurent Gate, Catherine Champmartin, Marie Claire Bottin, Gérard Keith, Jean Claude Micillino, Lucie Ayi-Fanou, Richard Wrobel, Hervé Nunge, Stéphane Binet, Aurélie Martin, Monhoven Nathalie

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2006, 596 (1-2), pp.91-105. ⟨10.1016/j.mrfmmm.2005.12.005⟩

Road paving workers are exposed to bitumen fumes (CAS No. 8052-42-4), a complex mixture of volatile compounds and particles containing carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons. However, epidemiological and experimental anima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5218314217348dbfc0cdb8839c3f56e2
https://doi.org/10.1016/j.mrfmmm.2005.12.005

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 2: intratracheal instillation and intravenous injection

Autor: Yves, Guichard, Marie-Aline, Maire, Sylvie, Sébillaud, Caroline, Fontana, Cristina, Langlais, Jean-Claude, Micillino, Christian, Darne, Joanna, Roszak, Maciej, Stępnik, Valérie, Fessard, Stéphane, Binet, Laurent, Gaté

Publikováno v: Environmental and molecular mutagenesis. 56(2)

Synthetic amorphous silica nanomaterials (SAS) are extensively used in food and tire industries. In many industrial processes, SAS may become aerosolized and lead to occupational exposure of workers through inhalation in particular. However, little i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f642fb3918639cc4522df69fab099476
https://pubmed.ncbi.nlm.nih.gov/25451515

In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts

Autor: Michèle Goutet, Marie-Claire Bottin, Christian Darne, Binet Stéphane, Schmit Julien, Yves Guichard, Laurent Gate, Cristina Langlais, Jean-Claude Micillino

Publikováno v: Journal of Toxicology, Vol 2010 (2010)
Journal of Toxicology

Asbestos-induced mutagenicity in the lung may involve reactive oxygen/nitrogen species (ROS/RNS) released by alveolar macrophages. With the aim of proposing an alternative in vitro mutagenesis test, a coculture system of rat alveolar macrophages (NR8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0591c576e115e789f497c491150ed6a
https://doaj.org/article/2f276caf0b5f471bb5b73647a2660f17