Výsledky vyhledávání - "Jean Claude Jardillier"

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Autor: Jean-Claude Jardillier, Muriel Affoué dit Faute, Hélène Bobichon, Luc Laurent, Marie-France Poupon, Dominique Ploton

Publikováno v: Clinical and Experimental Metastasis. 19:161-167

Growth of human tumor cells as three-dimensional (3D) multicellular spheroids modifies their invasive properties. Here we study the differences in the biological features of MCF-7, a human breast cancer cell line, and its multidrug resistant variant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9ce51227c67e5b499eb4953c5af32df
https://doi.org/10.1023/a:1014594825502

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Structural Basis of Topotecan−DNA Recognition Probed by Flow Linear Dichroism, Circular Dichroism, and Raman Spectroscopy

Autor: Strel'tsov Sa, Vladimir A. Oleinikov, S. L. Grokhovsky, Igor Nabiev, Alexei L. Zhuze, A. L. Mikheikin, Irina Kudelina, Konstantin Mochalov, Alyona Sukhanova, Jean-Claude Jardillier

Publikováno v: The Journal of Physical Chemistry B. 105:9643-9652

Camptothecin (CPT) and its clinically important antitumor derivative topotecan (Tpt) were traditionally described as unique antitumor compounds exhibiting no affinity toward DNA alone or DNA topoisomerase I (top1) alone but interacting with both the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a25028fc6d5cf195e5b63fba872b9595
https://doi.org/10.1021/jp0112166

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Human DNA topoisomerase I inhibitory activities of synthetic polyamines relation to DNA aggregation

Autor: Jean-Claude Jardillier, Jérôme Devy, Jean-Claude Bradley, Michel Pluot, Jean-Pierre Vigneron, Igor Nabiev, Jean-Marie Lehn, Alyona Sukhanova

Publikováno v: Bioorganic & Medicinal Chemistry. 9:1255-1268

DNA aggregation by polyamines has acquired importance as a prerequisite for the cellular uptake of DNA for gene therapy. Intracellular polyamines are constitutive components of mammalian cells and their availability is critical for cell proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffc777e0005af873c930c5c26e90629
https://doi.org/10.1016/s0968-0896(01)00009-8

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Identification of chromosomal loci associated with non-P-glycoprotein-mediated multidrug resistance to topoisomerase II inhibitor in lung adenocarcinoma cell line by comparative genomic hybridization

Autor: Linda Masson, Martine Doco-Fenzy, Pascale Cornillet-Lefebvre, Marylène Proult, Stéphanie Struski, Nadine Gruson, Evelyne Ulrich, Gérard Potron, Aurélie Trussardi, Jean-Claude Jardillier

Publikováno v: Genes, Chromosomes and Cancer. 30:136-142

In order to identify genomic changes associated with an etoposide resistance acquisition, we used comparative genomic hybridization (CGH) to compare a human lung adenocarcinoma cell line, A549 wild type, and three sublines, A549-VP1-3, exposed to inc

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https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1071>3.0.co

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Interaction Between Mevalonate Pathway and Retinoic Acid-Induced Differentiation

Autor: Christine Chomienne, Naima Gueddari-Pouzols, Jean Claude Jardillier, Patrick Duriez, Aurélie Trussardi

Publikováno v: Journal of Biomedicine and Biotechnology, Vol 1, Iss 3, Pp 108-113 (2001)
Journal of Biomedicine and Biotechnology

Alltransretinoic acid (ATRA) is a potent inducer of differentiation of HL-60 cell line. The pretreatment of the cells by compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl (HMG) CoA reductase, during 24 hours, enhances the ATRA-induced

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https://doaj.org/article/dbe7fc43704e419dae379159c1ec88e6

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Multicellular resistance: a paradigm for clinical resistance?

Autor: Jean-Claude Jardillier, Bernard Desoize

Publikováno v: Critical Reviews in Oncology/Hematology. 36:193-207

Research on resistance to cancer treatment was mainly focused for 20 years on multidrug resistance (MDR). No useful method of reversing MDR, suitable for clinical use, has yet emerged from this large quantity of work. The reason could be an inadequat

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https://doi.org/10.1016/s1040-8428(00)00086-x

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Partial restoration of all trans retinoic acid (ATRA) sensitivity by compactin in ATRA-resistant leukemic cells (ATRA-R HL-60)

Autor: Jean Claude Jardillier, P Lefebvre, Claudie Madoulet, Christine Chomienne, Laurence Berthou, Naima Gueddari

Publikováno v: Leukemia Research. 24:543-548

The resistance to all trans retinoic acid (ATRA) differentiating treatment is a consequence, in most of the cases, of either increased catabolism or down regulation of ATRA uptake. Recently, we have shown that ATRA efficiency to differentiate HL-60 c

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https://doi.org/10.1016/s0145-2126(00)00019-9

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Molecular Determinants of Site-specific Inhibition of Human DNA Topoisomerase I by Fagaronine and Ethoxidine

Autor: Igor Nabiev, Jean Claude Jardillier, Fabrice Fleury, Alain J.P. Alix, Anatoli Ianoul, Irina Kudelina, Jérôme Devy, Olivier Duval, Alyona Sukhanova

Publikováno v: Journal of Biological Chemistry. 275:3501-3509

DNA topoisomerase (top) I inhibition activity of the natural alkaloid fagaronine (NSC157995) and its new synthetic derivative ethoxidine (12-ethoxy-benzo[c]phenanthridine) has been correlated with their molecular interactions and sequence specificity

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https://doi.org/10.1074/jbc.275.5.3501

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Raman and surface-enhanced Raman scattering spectroscopy of bis-netropsins and their DNA complexes

Autor: Mikhail A. Ermishov, E. Kryukov, Igor Nabiev, Alyona Sukhanova, Alexei L. Zhuze, Jean Claude Jardillier, S. L. Grokhovsky, Vladimir Oleinikov

Publikováno v: Biopolymers. 57:272-281

The interactions of three bis-netropsins (bis-Nts), which are potent cata- lytic inhibitors of DNA-binding enzymes, with three double-stranded oligonucleotides (OLIGs), which contain sites of different specific affinities for each bis-Nt, were ana- l

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https://doi.org/10.1002/1097-0282(2000)57:5<272::aid-bip40>3.0.co

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DNA Binding by Fagaronine and Ethoxidine, Inhibitors of Human DNA Topoisomerases I and II, Probed by SERS and Flow Linear Dichroism Spectroscopy

Autor: Roger Waigh, Olivier Duval, Igor Nabiev, Fabrice Fleury, Jean-Claude Jardillier, and Alain J. P. Alix, Anatoli Ianoul

Publikováno v: The Journal of Physical Chemistry B. 103:2008-2013

Raman, surface-enhanced Raman scattering (SERS), and flow linear dichroism (FLD) spectroscopies were employed to study the potent anticancer agent fagaronine (FGR, NSC 157995) and its derivative ethoxidine (ETX)sinhibitors of DNA topoisomerases (topo

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https://doi.org/10.1021/jp984291y

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