Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jean Claude Hannaert"'
Autor:
Karine H Hellemans, Jean-Claude Hannaert, Bart Denys, Knut R Steffensen, Cindy Raemdonck, Geert A Martens, Paul P Van Veldhoven, Jan-Ake Gustafsson, Daniel Pipeleers
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7266 (2009)
Chronically elevated levels of fatty acids-FA can cause beta cell death in vitro. Beta cells vary in their individual susceptibility to FA-toxicity. Rat beta cells were previously shown to better resist FA-toxicity in conditions that increased trigly
Externí odkaz:
https://doaj.org/article/139ce2ea13384226bea0bc3ef4a7c07d
Autor:
Karine Hellemans, Jean-Claude Hannaert, Karen Kerckhofs, Daniel Pipeleers, Geert A. Martens, Paul P. Van Veldhoven
Publikováno v:
FEBS Journal. 274:6094-6105
Fatty acids can stimulate the secretory activity of insulin-producing beta-cells. At elevated concentrations, they can also be toxic to isolated beta-cells. This toxicity varies inversely with the cellular ability to accumulate neutral lipids in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::925a7270709fbfb15dee338df5238d56
https://doi.org/10.1111/j.1742-4658.2007.06131.x
https://doi.org/10.1111/j.1742-4658.2007.06131.x
Autor:
Jean-Claude Hannaert, Peter In't Veld, Miriam Pipeleers-Marichal, Willy Gepts, Marleen Berghmans, Jan Rozing, Daniel Pipeleers, Marnix Van De Winkel
Publikováno v:
Diabetes. 40:908-919
A standardized procedure was developed for the preparation of rat islet cell grafts with selected cell number and composition. After collagenase digestion of pancreases and elutriation of tissue fragments, islets were isolated and dissociated, and ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091a038d5438f265b229dd6cc92ab6c4
https://doi.org/10.2337/diabetes.40.7.908
https://doi.org/10.2337/diabetes.40.7.908
Publikováno v:
Endocrinology. 143(9)
Islet beta-cells express receptors for low density (LDL) and very low density (VLDL) lipoproteins that are internalized by receptor-mediated endocytosis. The present study examined whether this process can affect the viability of isolated rat islet b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d90af43a52f70359874b5496460952d
https://pubmed.ncbi.nlm.nih.gov/12193557
https://pubmed.ncbi.nlm.nih.gov/12193557
Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity
Publikováno v:
Biochemical Pharmacology, 63
Thiazolidinediones are a novel class of antidiabetic drugs that reduce insulin resistance through interaction with nuclear peroxisome proliferator-activated receptor (PPAR)gamma. One of these agents, troglitazone, was also proposed to protect beta ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b5511650a4c8f3fe978dac02ffa0e3
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/18033
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/18033
Publikováno v:
Diabetes. 50(8)
Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden pancreatic beta-cells as a result of the formation of ceramides, which induce nitric oxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a751928053ddb43253709d93b00322
https://pubmed.ncbi.nlm.nih.gov/11473037
https://pubmed.ncbi.nlm.nih.gov/11473037
Autor:
Miriam Cnop, C. Van Schravendijk, Annick Y. Grupping, T. J. C. Van Berkel, Daniel Pipeleers, Jean Claude Hannaert
Publikováno v:
Endocrinology. 138(10)
Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic β cells. This study investigates whether low density lipoproteins (LDL) ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e69982c94d4d122f73cb1c0b1a4a7b
https://pubmed.ncbi.nlm.nih.gov/9322913
https://pubmed.ncbi.nlm.nih.gov/9322913
Publikováno v:
Vrije Universiteit Brussel
This study quantifies the survival of purified single rat beta cells under different culture conditions. Less than 10% of the cells survive 9 days of culture in Ham's F10 medium without supplements. Addition of fetal calf serum (5%) increases cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9dc2b77a23317f19480fb562faf683
https://pubmed.ncbi.nlm.nih.gov/7512059
https://pubmed.ncbi.nlm.nih.gov/7512059
Autor:
Knut R. Steffensen, Daniel Pipeleers, Cindy Raemdonck, Karine Hellemans, Jan-Åke Gustafsson, Jean Claude Hannaert, G. Martens, Bart Denys, Paul P. Van Veldhoven
Publikováno v:
Vrije Universiteit Brussel
PLoS ONE, Vol 4, Iss 9, p e7266 (2009)
PLoS ONE
PLoS ONE, Vol 4, Iss 9, p e7266 (2009)
PLoS ONE
Chronically elevated levels of fatty acids-FA can cause beta cell death in vitro. Beta cells vary in their individual susceptibility to FA-toxicity. Rat beta cells were previously shown to better resist FA-toxicity in conditions that increased trigly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0203676297492e6c00a90dd5074226
https://doi.org/10.1371/journal.pone.0007266
https://doi.org/10.1371/journal.pone.0007266