Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Jean Clairambault"'
Publikováno v:
Mathematical Biosciences and Engineering, Vol 16, Iss 5, Pp 4818-4845 (2019)
We propose a mathematical model to describe the evolution of hematopoietic stem cells (HSCs) and stromal cells in considering the bi-directional interaction between them. Cancerous cells are also taken into account in our model. HSCs are structured b
Externí odkaz:
https://doaj.org/article/41b3e95cd2fd4d82b3fd30280b158652
Autor:
Jean Clairambault
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/ece3f3725a2346afa2b09a6be69fab37
Autor:
Shensi Shen, Jean Clairambault
Publikováno v:
F1000Research, Vol 9 (2020)
In this review, we propose a recension of biological observations on plasticity in cancer cell populations and discuss theoretical considerations about their mechanisms.
Externí odkaz:
https://doaj.org/article/5d0d149ceb084fb18ac9cedab644554e
Autor:
Jean Clairambault, Camille Pouchol
Publikováno v:
Biomath, Vol 8, Iss 1 (2019)
This article is a proceeding survey (deepening a talk given by the first author at the Biomath 2019 International Conference on Mathematical Models and Methods, held in Bedlewo, Poland) of mathematical models of cancer and healthy cell population ada
Externí odkaz:
https://doaj.org/article/52b9e661fe0841b3902a57a1b995f278
Autor:
Ján Eliaš, Jean Clairambault
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 10, Iss 16, Pp 12-22 (2014)
Spatio-temporal dynamics of a variety of proteins is, among other things, regulated by post-translational modifications of these proteins. Such modifications can thus influence stability and biochemical activities of the proteins, activity and stabil
Externí odkaz:
https://doaj.org/article/e4029f1fbfda41a0950fec2ace0d6b17
Autor:
Annabelle Ballesta, Sandrine Dulong, Chadi Abbara, Boris Cohen, Alper Okyar, Jean Clairambault, Francis Levi
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 9, p e1002143 (2011)
Circadian timing largely modifies efficacy and toxicity of many anticancer drugs. Recent findings suggest that optimal circadian delivery patterns depend on the patient genetic background. We present here a combined experimental and mathematical appr
Externí odkaz:
https://doaj.org/article/2c16131466da4f039d02a5470af19687
Autor:
Jean Clairambault, Alexandre Escargueil, Luís Neves de Almeida, Annette K. Larsen, Alexander Lorz, Tommaso Lorenzi, Rebecca H. Chisholm
Supplementary Movie 2. The cell population moving through the phenotype space during one simulation of the individual-based model. In this case there are no DTPs present in the initial population, only PC9 cells. Individual cells are shown as blue ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b1d38319fabf55a00b801f9b2b92fc
https://doi.org/10.1158/0008-5472.22407750.v1
https://doi.org/10.1158/0008-5472.22407750.v1
Autor:
Jean Clairambault, Alexandre Escargueil, Luís Neves de Almeida, Annette K. Larsen, Alexander Lorz, Tommaso Lorenzi, Rebecca H. Chisholm
Supplementary Material, Tables S1-S2, and Figures S1-S7. Table S1. Biological considerations relating to stress-induced adaptation of cell proliferation levels with the corresponding mathematical assumptions. Table S2. Biological considerations relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583539a6537505a4575b36f8afe06edb
https://doi.org/10.1158/0008-5472.22407756
https://doi.org/10.1158/0008-5472.22407756
Autor:
Jean Clairambault, Alexandre Escargueil, Luís Neves de Almeida, Annette K. Larsen, Alexander Lorz, Tommaso Lorenzi, Rebecca H. Chisholm
Supplementary Movie 1. The cell population moving through the phenotype space during one simulation of the individual-based model. In this case there are some DTPs present in the initial population (5%) together with the PC9 cells (95%). Individual c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e974113b5ee7496c55140a7b83037c
https://doi.org/10.1158/0008-5472.22407753
https://doi.org/10.1158/0008-5472.22407753
Autor:
Jean Clairambault, Alexandre Escargueil, Luís Neves de Almeida, Annette K. Larsen, Alexander Lorz, Tommaso Lorenzi, Rebecca H. Chisholm
In recent experiments on isogenetic cancer cell lines, it was observed that exposure to high doses of anticancer drugs can induce the emergence of a subpopulation of weakly proliferative and drug-tolerant cells, which display markers associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8415adc30747c03594b75c8b5a0d46ff
https://doi.org/10.1158/0008-5472.c.6507375
https://doi.org/10.1158/0008-5472.c.6507375