Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jean Christophe Pointud"'
Autor:
Damien Dufour, Typhanie Dumontet, Isabelle Sahut-Barnola, Aude Carusi, Méline Onzon, Eric Pussard, James Jr Wilmouth, Julie Olabe, Cécily Lucas, Adrien Levasseur, Christelle Damon-Soubeyrand, Jean-Christophe Pointud, Florence Roucher-Boulez, Igor Tauveron, Guillaume Bossis, Edward T. Yeh, David T. Breault, Pierre Val, Anne-Marie Lefrançois-Martinez, Antoine Martinez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
SUMOylation is a mechanism of posttranslational modification involved in eukaryotic cell homeostasis. Here the authors report that mice unable to control SUMOylation in the adrenal cortex develop a selective defect in glucocorticoid production due to
Externí odkaz:
https://doaj.org/article/94675fdf0b57490d98010c427e95a3d3
Autor:
Coralie Drelon, Annabel Berthon, Isabelle Sahut-Barnola, Mickaël Mathieu, Typhanie Dumontet, Stéphanie Rodriguez, Marie Batisse-Lignier, Houda Tabbal, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Celso E. Gomez-Sanchez, Seppo Vainio, Jingdong Shan, Sonia Sacco, Andreas Schedl, Constantine A. Stratakis, Antoine Martinez, Pierre Val
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WN
Externí odkaz:
https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea
Autor:
James J. Wilmouth, Julie Olabe, Diana Garcia-Garcia, Cécily Lucas, Rachel Guiton, Florence Roucher-Boulez, Damien Dufour, Christelle Damon-Soubeyrand, Isabelle Sahut-Barnola, Jean-Christophe Pointud, Yoan Renaud, Adrien Levasseur, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Antoine Martinez, Pierre Val
Publikováno v:
Science Advances
Science Advances, 2022, 8 (41), ⟨10.1126/sciadv.add0422⟩
Science Advances, 2022, 8 (41), ⟨10.1126/sciadv.add0422⟩
SummaryIn contrast with most cancers, adrenocortical carcinomas (ACC) are more frequent in women than men, but the underlying mechanisms of this sexual dimorphism remain elusive. Homozygous deletion of the negative WNT pathway regulator ZNRF3 is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa770a0a84d3d41c96cad1df1fd90a1
https://cnrs.hal.science/hal-03864625
https://cnrs.hal.science/hal-03864625
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
Aldose reductase proteins are cytosolic monomeric enzymes, belonging to the aldo-keto reductase (AKR) superfamily. They perform oxidoreduction of carbonyl groups from a wide variety of substrates such as aliphatic and aromatic aldehydes or ketones. T
Externí odkaz:
https://doaj.org/article/a67446c0a6cb4c16a23bb93c080ebcbc
Autor:
Anne-Marie Lefrançois-Martinez, Amandine Septier, Amanda Swain, Jean-Christophe Pointud, Constantine A. Stratakis, Fabio R. Faucz, Florian Guillou, James Wilmouth, Antoine-Guy Lopez, Adrien Levasseur, Ingrid Plotton, Cyril Djari, Seppo Vainio, Crystal Kamilaris, Isabelle Sahut-Barnola, Hervé Lefebvre, Damien Dufour, Pierre Val, Nathanaëlle Montanier, Antoine Martinez, Igor Tauveron
Publikováno v:
The Journal of clinical investigation
The Journal of clinical investigation, 2021, 131 (23), ⟨10.1172/JCI146910⟩
J Clin Invest
The Journal of clinical investigation, 2021, 131 (23), pp.1-18. ⟨10.1172/JCI146910⟩
The Journal of clinical investigation, 2021, 131 (23), ⟨10.1172/JCI146910⟩
J Clin Invest
The Journal of clinical investigation, 2021, 131 (23), pp.1-18. ⟨10.1172/JCI146910⟩
International audience; Large-cell calcifying Sertoli cell tumors (LCCSCTs) are among the most frequent lesions occurring in male Carney complex (CNC) patients. Although they constitute a key diagnostic criterion for this rare multiple neoplasia synd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa42b91af6fe83aa0f6186699768eadc
https://hal.inrae.fr/hal-03462738
https://hal.inrae.fr/hal-03462738
Autor:
Bruno Ragazzon, Jean-Christophe Pointud, Houda Tabbal, Pierre Val, Igor Tauveron, Coralie Drelon, M. Batisse-Lignier, Cyril Djari, Stéphanie Rodriguez, Anne-Marie Lefrançois-Martinez, Amandine Septier, Jérôme Bertherat, Guillaume Assié, Isabelle Sahut-Barnola, Mickael Mathieu, Antoine Martinez
Publikováno v:
British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, Cancer Research UK, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
British Journal of Cancer, 2019, 121 (5), pp.384-394. ⟨10.1038/s41416-019-0538-y⟩
International audience; BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e8aeb4b82b5deb9b1796239f7afa18
https://doi.org/10.1038/s41416-019-0538-y
https://doi.org/10.1038/s41416-019-0538-y
Autor:
Isabelle Sahut-Barnola, Cyrille de Joussineau, Pierre Val, Sarah Lambert-Langlais, Christelle Damon, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Geoffroy Marceau, Vincent Sapin, Frédérique Tissier, Bruno Ragazzon, Jérôme Bertherat, Lawrence S Kirschner, Constantine A Stratakis, Antoine Martinez
Publikováno v:
PLoS Genetics, Vol 6, Iss 6, p e1000980 (2010)
Carney complex (CNC) is an inherited neoplasia syndrome with endocrine overactivity. Its most frequent endocrine manifestation is primary pigmented nodular adrenocortical disease (PPNAD), a bilateral adrenocortical hyperplasia causing pituitary-indep
Externí odkaz:
https://doaj.org/article/a48e51e04751405a855b77fc9951dea7
Autor:
Sarah Lambert-Langlais, Jean-Christophe Pointud, Anne-Marie Lefrançois-Martinez, Fanny Volat, Michèle Manin, François Coudoré, Pierre Val, Isabelle Sahut-Barnola, Bruno Ragazzon, Estelle Louiset, Catherine Delarue, Hervé Lefebvre, Yoshihiro Urade, Antoine Martinez
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7309 (2009)
Prostaglandin F(2alpha) (PGF(2alpha)), represses ovarian steroidogenesis and initiates parturition in mammals but its impact on adrenal gland is unknown. Prostaglandins biosynthesis depends on the sequential action of upstream cyclooxygenases (COX) a
Externí odkaz:
https://doaj.org/article/f7ea7cd6f06f4ea7acca0a911bd2f0a6
Autor:
E.T.. Yeh, Pierre Val, D. Dufour, T. Dumontet, Jean-Christophe Pointud, Isabelle Sahut-Barnola, Anne-Marie Lefrançois-Martinez, Antoine Martinez, E. Pussard, G. Bossis
Publikováno v:
Annales d'Endocrinologie. 81:162-163
La glande corticosurrenale produit les corticosteroides necessaires a l’homeostasie hydrominerale et metabolique de l’organisme. Elle s’organise, chez la souris, en deux regions concentriques, les zones glomerulee (zG) et fasciculee (zF), renou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8771b603d21a1afd3d8cd4bb26d6cc5f
https://doi.org/10.1016/j.ando.2020.07.125
https://doi.org/10.1016/j.ando.2020.07.125
Autor:
T. Dumontet, Antoine Martinez, Bruno Ragazzon, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Nathanaëlle Montanier, Jérôme Bertherat, Igor Tauveron, Florence Roucher-Boulez, Isabelle Sahut-Barnola, Annabel Berthon, Damien Dufour, Pierre Val, Cyril Djari, M. Batisse-Lignier
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (9), pp.10218-10230. ⟨10.1096/fj.201900557R⟩
FASEB Journal, 2019, 33 (9), pp.10218-10230. ⟨10.1096/fj.201900557R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (9), pp.10218-10230. ⟨10.1096/fj.201900557R⟩
FASEB Journal, 2019, 33 (9), pp.10218-10230. ⟨10.1096/fj.201900557R⟩
SUMOylation is a highly conserved and dynamic post-translational mechanism primarily affecting nuclear programs for adapting organisms to stressful challenges. Alteration of SUMOylation cycles leads to severe developmental and homeostatic defects and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4d363279b1383215c0440c4736dec9
https://hal.archives-ouvertes.fr/hal-02351273
https://hal.archives-ouvertes.fr/hal-02351273