Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Jean Christophe Lambry"'
Autor:
Jonathan Filée, Hubert F. Becker, Lucille Mellottee, Rima Zein Eddine, Zhihui Li, Wenlu Yin, Jean-Christophe Lambry, Ursula Liebl, Hannu Myllykallio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Asgard archaea include the closest known archaeal relatives of eukaryotes. Here, the authors provide evidence that eukaryotic and Asgard thymidylate synthases (required for DNA synthesis) may have a bacterial origin, and additional lateral transfer o
Externí odkaz:
https://doaj.org/article/5a94de8dfcf84a1fa8bead9006dbbaad
Autor:
Nicolas G. Biteau, Vincent Roy, Cyril Nicolas, Hubert F. Becker, Jean-Christophe Lambry, Hannu Myllykallio, Luigi A. Agrofoglio
Publikováno v:
Molecules, Vol 27, Iss 19, p 6216 (2022)
In 2002, a new class of thymidylate synthase (TS) involved in the de novo synthesis of dTMP named Flavin-Dependent Thymidylate Synthase (FDTS) encoded by the thyX gene was discovered; FDTS is present only in 30% of prokaryote pathogens and not in hum
Externí odkaz:
https://doaj.org/article/fa166c10908c426bb800a1ee50e5ea63
Autor:
Jonathan Filée, Hubert F. Becker, Lucille Mellottee, Rima Zein Eddine, Zhihui Li, Wenlu Yin, Jean-Christophe Lambry, Ursula Liebl, Hannu Myllykallio
Publikováno v:
Nature Communications
Nature Communications, 2023, ⟨10.1038/s41467-023-36487-z⟩
Nature Communications, 2023, ⟨10.1038/s41467-023-36487-z⟩
International audience; Asgard archaea include the closest known archaeal relatives of eukaryotes. Here, we investigate the evolution and function of Asgard thymidylate synthases and other folate-dependent enzymes required for the biosynthesis of DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfd3ccc7c2ce5bb0b99762b2b1d897c
https://cnrs.hal.science/hal-03996793/file/s41467-023-36487-z-1.pdf
https://cnrs.hal.science/hal-03996793/file/s41467-023-36487-z-1.pdf
Autor:
Jonathan Filée, Hubert F. Becker, Lucille Mellottee, Zhihui Li, Jean-Christophe Lambry, Ursula Liebl, Hannu Myllykallio
Little is known about the evolution and biosynthetic function of DNA precursor and the folate metabolism in the Asgard group of archaea. As Asgard occupy a key position in the archaeal and eukaryotic phylogenetic trees, we have exploited very recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e09d6a2ed9411219ff3fc872ee7886
https://doi.org/10.1101/2021.12.15.472764
https://doi.org/10.1101/2021.12.15.472764
Autor:
Stéphane Skouloubris, Kamel Djaout, Isabelle Lamarre, Jean-Christophe Lambry, Karine Anger, Julien Briffotaux, Ursula Liebl, Hilde de Reuse, Hannu Myllykallio
Publikováno v:
Open Biology, Vol 5, Iss 6 (2015)
ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacteria
Externí odkaz:
https://doaj.org/article/72786186d0a9436da8dd64ed0d2101d5
Autor:
Pierre Sournia, Bo Zhuang, Rivo Ramodiharilafy, Marten H. Vos, Anastasia Croitoru, Ursula Liebl, Hannu Myllykallio, Alexey Aleksandrov, Lipsa Nag, Jean-Christophe Lambry
Publikováno v:
Photochemical & Photobiological Sciences
Photochemical & Photobiological Sciences, 2021, 20 (5), pp.663-670. ⟨10.1007/s43630-021-00052-8⟩
Photochemical & Photobiological Sciences, Royal Society of Chemistry, 2021, 20 (5), pp.663-670. ⟨10.1007/s43630-021-00052-8⟩
Photochemical & Photobiological Sciences, 2021, 20 (5), pp.663-670. ⟨10.1007/s43630-021-00052-8⟩
Photochemical & Photobiological Sciences, Royal Society of Chemistry, 2021, 20 (5), pp.663-670. ⟨10.1007/s43630-021-00052-8⟩
International audience; Quenching of flavin fluorescence by electron transfer from neighboring aromatic residues is ubiquitous in flavoproteins. Apart from constituting a functional process in specific light-active systems, time-resolved spectral cha
Autor:
Andreas M. Köster, Bernardo Zuniga-Gutierrez, Tzonka Mineva, Gerald Geudtner, Luis-Ignacio Hernández-Segura, Luis López-Sosa, Juan D. Samaniego-Rojas, Roberto Flores-Moreno, José Alejandre, Badhin Gomez, Rogelio Isaac Delgado-Venegas, Jean-Christophe Lambry, Aurélien de la Lande, Patrizia Calaminici
This chapter describes the theoretical background of the quantum mechanical/molecular mechanical (QM/MM) implementation in deMon2k within the framework of auxiliary density functional theory (ADFT). It aims to give the reader an overview of the curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46beff662e06a79662e623eba7dbeb42
https://doi.org/10.1039/9781839164668-00001
https://doi.org/10.1039/9781839164668-00001
Autor:
Hubert F. Becker, Nicolas G. Biteau, Jean-Christophe Lambry, Vincent Roy, Luigi A. Agrofoglio, Hannu Myllykallio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2021, 46, pp.116351. ⟨10.1016/j.bmc.2021.116351⟩
Bioorganic & Medicinal Chemistry Letters, 2021, 46, pp.116351. ⟨10.1016/j.bmc.2021.116351⟩
International audience; Flavin-Dependent Thymidylate Synthase (FDTS) encoded by ThyX gene was discovered as a new class of thymidylate synthase involved in the de novo synthesis of dTMP named only in 30 % of human pathogenic bacteria. This target was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55da1dda58480e595cbb7ee928de022
https://doi.org/10.1016/j.bmc.2021.116351
https://doi.org/10.1016/j.bmc.2021.116351
Autor:
Tamara Basta, Yap Boum, Julien Briffotaux, Hubert F. Becker, Isabelle Lamarre-Jouenne, Jean-Christophe Lambry, Stephane Skouloubris, Ursula Liebl, Marc Graille, Herman van Tilbeurgh, Hannu Myllykallio
Publikováno v:
Open Biology, Vol 2, Iss 10 (2012)
Nature has established two mechanistically and structurally unrelated families of thymidylate synthases that produce de novo thymidylate or dTMP, an essential DNA precursor. Representatives of the alternative flavin-dependent thymidylate synthase fam
Externí odkaz:
https://doaj.org/article/f992c67499fc405c97a0c7d9e882a271
Autor:
Yoshizumi Ishino, Hanae Kudo, Asmae Es-Sadik, Caroline L'Hermitte-Stead, Sonoko Ishino, Jean Christophe Lambry, Stéphane Skouloubris, Hannu Myllykallio
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2018, ⟨10.1093/nar/gky460⟩
Nucleic Acids Research, Oxford University Press, 2018, ⟨10.1093/nar/gky460⟩
International audience; The mismatch repair (MMR) system, exemplified by the MutS/MutL proteins, is widespread in Bacteria and Eukarya. However, molecular mechanisms how numerous archaea and bacteria lacking the mutS/mutL genes maintain high replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702e013dd7a9cb60801ba57aac779da2
https://hal.archives-ouvertes.fr/hal-01873297
https://hal.archives-ouvertes.fr/hal-01873297