Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Jean Chmielewski"'
Publikováno v:
Nanomaterials, Vol 13, Iss 19, p 2645 (2023)
Peptide-based helical barrels are a noteworthy building block for hierarchical assembly, with a hydrophobic cavity that can serve as a host for cargo. In this study, disulfide-stapled helical barrels were synthesized containing ligands for metal ions
Externí odkaz:
https://doaj.org/article/8997563849e4462c8c3c63185616a1a4
Publikováno v:
Molecules, Vol 28, Iss 7, p 2953 (2023)
Magnetic resonance imaging (MRI) is a medical imaging technique that provides detailed information on tissues and organs. However, the low sensitivity of the technique requires the use of contrast agents, usually ones that are based on the chelates o
Externí odkaz:
https://doaj.org/article/567be190a73f480abf8132b2f78e5b0c
Publikováno v:
Molecules, Vol 26, Iss 16, p 4888 (2021)
Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes wit
Externí odkaz:
https://doaj.org/article/5d32894cd6ed43be86063f3f918f1207
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Antimicrobial peptides (AMPs) represent a promising therapeutic alternative for the treatment of antibiotic-resistant bacterial infections. The present study investigates the antimicrobial activity of new, rationally-designed derivatives of
Externí odkaz:
https://doaj.org/article/5369fd7d7b3c42f8b424b36262d3446f
Autor:
Kevin Strauss, Jean Chmielewski
Publikováno v:
Materials, Vol 9, Iss 10, p 838 (2016)
Biofunctional scaffolds for the delivery of living cells are of the utmost importance for regenerative medicine. Herein, a novel, robust “spiraled horn” scaffold was elucidated through the Co2+-promoted hierarchical assembly of two collagen mimet
Externí odkaz:
https://doaj.org/article/cbaa799f84d84e49ad3f474264f5e164
Co-assembled Coiled-Coil Peptide Nanotubes with Enhanced Stability and Metal-Dependent Cargo Loading
Autor:
Michael D. Jorgensen, Jean Chmielewski
Publikováno v:
ACS Omega. 7:20945-20951
Peptide nanotube biomaterials are attractive for their range of applications. Herein, we disclose the co-assembly of coiled-coil peptides, one with ligands for metal ions that demonstrate hierarchical assembly into nanotubes, with spatial control of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572558dcf66d634c799a5998c21d0bc3
https://doi.org/10.1021/acsomega.2c01669
https://doi.org/10.1021/acsomega.2c01669
Autor:
Ryan W. Curtis, Kevin L. Scrudders, James R. W. Ulcickas, Garth J. Simpson, Shalini T. Low-Nam, Jean Chmielewski
Publikováno v:
ACS Biomater Sci Eng
The use of biomaterials for the inclusion and stabilization of biopolymers is an ongoing challenge. Herein, we disclose three-dimensional (3D) coiled-coil peptide crystals with metal ions that include and overgrow His-tagged fluorescent proteins with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa735f10305d168e8577d626a0022e8
https://doi.org/10.1021/acsbiomaterials.2c00155
https://doi.org/10.1021/acsbiomaterials.2c00155
Autor:
Michael D. Jorgensen, Jean Chmielewski
Publikováno v:
Chemical Communications. 58:11625-11636
Extensive research has gone into deciphering the sequence requirements for peptides to fold into coiled-coils of varying oligomeric states. More recently, additional signals have been introduced within coiled-coils to promote higher order assembly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620587dda82ae6c420dbe1a46f901bea
https://doi.org/10.1039/d2cc04434j
https://doi.org/10.1039/d2cc04434j
Publikováno v:
Peptide Science. 114
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d9ac6f7ab87343569984a9c742889c
https://doi.org/10.1002/pep2.24265
https://doi.org/10.1002/pep2.24265
Autor:
Jean Chmielewski, Samantha M. Zeiders
Publikováno v:
Chemical biologydrug designREFERENCES. 98(5)
The failure to treat everyday bacterial infections is a current threat as pathogens are finding new ways to thwart antibiotics through mechanisms of resistance and intracellular refuge, thus rendering current antibiotic strategies ineffective. Cell p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c81791d57801a9e9fe039a5fb1a4e1c
https://pubmed.ncbi.nlm.nih.gov/34315189
https://pubmed.ncbi.nlm.nih.gov/34315189