Oxidative Transformation of Dihydroflavonols and Flavan-3-ols by Anthocyanidin Synthase from Vitis vinifera

Autor: Jia-Rong Zhang, Claudine Trossat-Magnin, Katell Bathany, Luc Negroni, Serge Delrot, Jean Chaudière

Publikováno v: Molecules, Vol 27, Iss 3, p 1047 (2022)

Twelve polyphenols from three distinct families (dihydroflavonols, flavan-3-ols, and flavanones) were studied as potential substrates of anthocyanidin synthase from Vitis vinifera (VvANS). Only flavan-3-ols of (2R,3S) configuration having either a ca

Externí odkaz: https://doaj.org/article/54488813a913466988b219e6ebccde71

J. Agric. Food Chem

Autor: Jia-rong Zhang, Béatrice Langlois d'Estaintot, Katell Bathany, Jean Chaudiere, James Tolchard

Publikováno v: Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry, American Chemical Society, 2018, 66 (1), pp.351-358
Journal of Agricultural and Food Chemistry, American Chemical Society, 2018, 66 (1), pp.351-358. ⟨10.1021/acs.jafc.7b04380⟩

(+)-2,3-trans-3,4-cis-Leucocyanidin was produced by acidic epimerization of (+)-2,3-trans-3,4-trans-leucocyanidin synthesized by reduction of (+)-dihydroquercetin with NaBH4, and structures of the two stereoisomers purified by C18- and phenyl-reverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e77bb831592e0c692522485c958c5c
https://hal.archives-ouvertes.fr/hal-03160315

The epimerase activity of anthocyanidin reductase from Vitis vinifera and its regiospecific hydride transfers

Autor: Katell Bathany, Claude Manigand, Chloé Maugé, Jean Chaudiere, Bernard Gallois, Mahmoud Gargouri, Jean-Marie Schmitter

Publikováno v: Biological Chemistry. 391:219-227

Anthocyanidin reductase (ANR) from Vitis vinifera catalyzes an NADPH-dependent double reduction of anthocyanidins producing a mixture of (2S,3R)- and (2S,3S)-flavan-3-ols. At pH 7.5 and 30°C, the first hydride transfer to anthocyanidin is irreversib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66999510059232497d471e395442c959
https://doi.org/10.1515/bc.2010.015

Structural evidence for the inhibition of grape dihydroflavonol 4-reductase by flavonols

Autor: Béatrice Langlois d'Estaintot, Pierre Petit, Bernard Gallois, Claude Manigand, Jean Chaudiere, Thierry Granier, Nadia Trabelsi

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 64:883-891

Dihydroflavonol 4-reductase (DFR) is a key enzyme of the flavonoid biosynthesis pathway which catalyses the NADPH-dependent reduction of 2R,3R-trans-dihydroflavonols to leucoanthocyanidins. The latter are the precursors of anthocyans and condensed ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286136ccf28620a235e9be729b44c6b2
https://doi.org/10.1107/s0907444908017769

Intracellular Antioxidants: from Chemical to Biochemical Mechanisms

Autor: Jean Chaudiere, R. Ferrari-Iliou

Publikováno v: Food and Chemical Toxicology. 37:949-962

Intracellular antioxidants include low molecular weight scavengers of oxidizing species, and enzymes which degrade superoxide and hydroperoxides. Such antioxidants systems prevent the uncontrolled formation of free radicals and activated oxygen speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47a624f1f8158cd343d73d5b84ec2ec
https://doi.org/10.1016/s0278-6915(99)00090-3