Výsledky vyhledávání - "Jean Carlos Lipreri Da Silva"

Akademický článek

Perspectives for Targeting Ezrin in Cancer Development and Progression

Autor: Jean Carlos Lipreri da Silva, Hugo Passos Vicari, João Agostinho Machado-Neto

Publikováno v: Future Pharmacology, Vol 3, Iss 1, Pp 61-79 (2023)

Recent advances have been made in understanding molecular markers involved in cancer malignancy, resulting in better tumor staging and identifying new potential therapeutic targets. Ezrin (EZR), a member of the ezrin, radixin, moesin (ERM) protein fa

Externí odkaz: https://doaj.org/article/2302659d83fd4c95b7ee4e7c41e2ea6c

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Akademický článek

P347: PHARMACOLOGICAL EZRIN INHIBITION REDUCES GROWTH, ADHESION, MIGRATION AND REGULATE GENE RELATED TO APOPTOSIS AND CELL CYCLE IN ACUTE LYMPHOBLASTIC LEUKAEMIA

Autor: Jean Carlos Lipreri Da Silva, Keli Lima, Mariana Lazarini, Hugo Passos Vicari, Eduardo Magalhães Rego, Benjamin Ede, Anne Ridley, João Agostinho Machado Neto

Publikováno v: HemaSphere, Vol 7, p e65047ca (2023)

Externí odkaz: https://doaj.org/article/cf05a4690cf647a09c2965dff6e2061e

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Akademický článek

Obatoclax reduces cell viability of acute myeloid leukemia cell lines independently of their sensitivity to venetoclax

Autor: Keli Lima, Hugo Passos Vicari, Jorge Antonio Elias Godoy Carlos, Jean Carlos Lipreri da Silva, Lorena Lobo de Figueiredo-Pontes, Eduardo Magalhães Rego, João Agostinho Machado-Neto

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 44, Iss 1, Pp 124-127 (2022)

Externí odkaz: https://doaj.org/article/9add93d6a22542bfad2878660233069f

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NSC305787, a pharmacological ezrin inhibitor, exhibits antineoplastic activity in pancreatic cancer cells

Autor: Jean Carlos Lipreri da Silva, Maria Fernanda Lopes Carvalho, Livia Bassani Lins de Miranda, Bruna Oliveira de Almeida, Keli Lima, João Agostinho Machado-Neto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Pancreatic cancer is one of the most lethal human neoplasms, and despite advances in the understanding of the molecular complexity involved in the development and progression of this disease, little of this new information has been translated into im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f856fbe05de7866f31e269ec5d5255e4
https://doi.org/10.1007/s10637-022-01249-z

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STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells

Autor: Rosane Bittencourt, Evandro M. Fagundes, Letícia V. Costa-Lotufo, Juan L Coelho-Silva, Antonio R. Lucena-Araujo, Fabio R. Kerbauy, Katia B Pagnano, Diego A Pereira-Martins, Jean Carlos Lipreri da Silva, João Agostinho Machado-Neto, Raul Am Melo, Priscila Santos Scheucher, Fabiola Traina, Eduardo Magalhães Rego, E.C. Nunes, Luisa C A Koury, Hugo Passos Vicari, Lorena Lobo de Figueiredo-Pontes, Keli Lima

Publikováno v: Investigational New Drugs. 40:438-452

Stathmin 1 (STMN1) is a microtubule-destabilizing protein highly expressed in hematological malignancies and involved in proliferation and differentiation. Although a previous study found that the PML-RARα fusion protein, which contributes to the pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29839a95a92233c3d2c3c2cd9bcb4b9d
https://doi.org/10.1007/s10637-021-01197-0

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Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia

Autor: Mariana Lazarini, Letícia V. Costa-Lotufo, Hugo Passos Vicari, Keli Lima, Fabiola Traina, Jean Carlos Lipreri da Silva, Juan L Coelho-Silva, João Agostinho Machado-Neto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Despite great advances that have been made in the understanding of the molecular complexity of acute myeloid leukemia (AML), very little has been translated into new therapies. Here, we set out to investigate the impact of cytoskeleton regulatory gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f8e88b1df83997bbe8fbd11d4e0a07
https://doi.org/10.1007/s13402-021-00621-0

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Ezrin is highly expressed and a druggable target in chronic lymphocytic leukemia

Autor: Jean Carlos Lipreri da Silva, Felipe Saldanha-Araujo, Raphael Costa Bandeira de Melo, Hugo Passos Vicari, Amandda Evelin Silva-Carvalho, Eduardo Magalhães Rego, Valeria Buccheri, João Agostinho Machado-Neto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Despite the development of therapeutic strategies for chronic lymphocytic leukemia (CLL), most patients remain incurable, relapse, or refractory to current treatments, indicating the need to expand the antineoplastic repertoire for this disease. Ezri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f004e0ad2effb7901f9c04baed3ab1a

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