Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport

Autor: Jean Cacheux, Aurélien Bancaud, Daniel Alcaide, Jun-Ichi Suehiro, Yoshihiro Akimoto, Hiroyuki Sakurai, Yukiko T. Matsunaga

Publikováno v: iScience, Vol 26, Iss 7, Pp 107141- (2023)

Summary: The endothelial layers of the microvasculature regulate the transport of solutes to the surrounding tissues. It remains unclear how this barrier function is affected by blood flow-induced intraluminal pressure. Using a 3D microvessel model,

Externí odkaz: https://doaj.org/article/f044b547d1bf4248a82afc855798a922

Microvessel-on-Chip Fabrication for the In Vitro Modeling of Nanomedicine Transport

Autor: Sergio Dávila, Jean Cacheux, Isabel Rodríguez

Publikováno v: ACS Omega, Vol 6, Iss 39, Pp 25109-25115 (2021)

Externí odkaz: https://doaj.org/article/b8c8ab9c1fc8413696b26e3bf9bbc93d

Technological Challenges and Future Issues for the Detection of Circulating MicroRNAs in Patients With Cancer

Autor: Jean Cacheux, Aurélien Bancaud, Thierry Leichlé, Pierre Cordelier

Publikováno v: Frontiers in Chemistry, Vol 7 (2019)

In the era of precision medicine, the success of clinical trials, notably for patients diagnosed with cancer, strongly relies on biomarkers with pristine clinical value but also on robust and versatile analytical technologies to ensure proper patient

Externí odkaz: https://doaj.org/article/bde728789c2f4a028376b9e28df066e4

micro-RNA 21 detection with a limit of 2 pM in 1 min using a size-accordable concentration module operated by electrohydrodynamic actuation

Autor: Pierre Cordelier, Bayan Chami, Thierry Leichle, Christophe Dez, Rémi Malbec, Jean Cacheux, Inga Tijunelyte, Aurélien Bancaud

Publikováno v: Biosensors and Bioelectronics
Biosensors and Bioelectronics, 2021, 178, pp.112992. ⟨10.1016/j.bios.2021.112992⟩
Biosensors and Bioelectronics, Elsevier, 2021, 178, pp.112992. ⟨10.1016/j.bios.2021.112992⟩

International audience; We present a fluorimetry-based technology for micro-RNA-21 (miR-21) sensing based on the concentration of miR-molecular beacon (MB) complexes and flushing of unbound MB. This concentration module consists of a microfluidic cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82eea8177985611368bc0fdc0ad9ab12
https://cnrs.hal.science/hal-03449104

Microfluidics for minute DNA sample analysis: open challenges for genetic testing of cell-free circulating DNA in blood plasma

Autor: Pierre Joseph, Aurélien Bancaud, Rémi Malbec, Thierry Leichle, Jean Cacheux, Pierre Cordelier

Publikováno v: Micro and Nano Engineering
Micro and Nano Engineering, Elsevier, 2018, 1, pp.25-32. ⟨10.1016/j.mne.2018.10.003⟩
Micro and Nano Engineering, 2018, 1, pp.25-32. ⟨10.1016/j.mne.2018.10.003⟩
Micro and Nano Engineering, 2018, 1, pp.25-32. 〈10.1016/j.mne.2018.10.003〉
Micro and Nano Engineering, Vol 1, Iss, Pp 25-32 (2018)

Genetic testing based on the analysis of circulating cell-free DNA (cfDNA) in body fluids, especially blood plasma, is raising interest for the management and follow-up of many diseases, including cancer. Because the concentration of cfDNA is low and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf1294056f8396b60704ad4a2d0b01f
https://doi.org/10.1016/j.mne.2018.10.003