Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jean C. Nichols"'
Autor:
Jean C. Nichols, Melody A. Farrar, Fermin O. Tio, Richard G. Bach, Cory A. Waters, Thasia G. Woodworth, Stephen B. Paige, Steven R. Bailey, D. Douglas Miller
Publikováno v:
Atherosclerosis. 126:1-14
Immunocytochemical analyses of human plaques and experimental arterial lesions have implicated activated lymphocytes and monocytes in the pathogenesis of atherosclerosis, as demonstrated by the expression of interleukin-2 (IL-2) membrane receptors an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f53428fdc5882f13152357b1a57bdba
https://doi.org/10.1016/0021-9150(96)05843-1
https://doi.org/10.1016/0021-9150(96)05843-1
Publikováno v:
Molecular and Cellular Biochemistry. 138:151-156
We have used protein engineering and recombinant DNA methodologies in order to construct a fusion protein in which human interleukin-2 (IL-2) is genetically linked to the catalytic and transmembrane domains of diphtheria toxin. The fusion toxin, DAB4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1b4424a9017c130a2eff1612019a33
https://doi.org/10.1007/bf00928457
https://doi.org/10.1007/bf00928457
Publikováno v:
European Journal of Immunology. 22:1673-1679
DAB486IL-2 is an interleukin-2 receptor-specific cytotoxin which selectively targets and kills cells which bear the high-affinity form of the IL-2 receptor. Since elimination of activated T lymphocytes may be useful in the treatment of rheumatoid art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dea7ec7665847bbc1911fd4a4baa16
https://doi.org/10.1002/eji.1830220702
https://doi.org/10.1002/eji.1830220702
Autor:
Robert A. Muggia, Oleh Pankewycz, Marcus G. Bastos, Alvaro Pacheco-Silva, Terry B. Strom, John R. Murphy, Jean C Nichols, Vicki E. Rubin-Kelley
Publikováno v:
European Journal of Immunology. 22:697-702
Insulin-dependent diabetes mellitus (IDDM) is strikingly similar in the non-obese diabetic (NOD) mouse and humans. In IDDM, the systematic autoimmune destruction of insulin-producing beta cells within the pancreas is dependent on autoreactive T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867957657d7fafcb49f64068ad96228d
https://doi.org/10.1002/eji.1830220312
https://doi.org/10.1002/eji.1830220312
Publikováno v:
Cellular Immunology. 132:481-493
Recombinant diphtheria toxin-related interleukin-2 fusion protein (DAB 486 IL-2) is specifically cytotoxic for cells bearing the high-affinity IL-2 receptor (p55/75). We evaluated the effects of DAB 486 IL-2 on the generation of tetanus toxoid(TT)-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a0a88f58cea2d9a28838e97871da7c
https://doi.org/10.1016/0008-8749(91)90044-c
https://doi.org/10.1016/0008-8749(91)90044-c
Publikováno v:
Journal of Neuroimmunology. 31:115-122
The pathogenesis of the autoimmune disease, myasthenia gravis (MG), involves an antibody-mediated attack against acetylcholine receptors (AChRs). Since the relevant antibody response is T cell dependent, a therapeutic strategy aimed at T lymphocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5c4232bf09d6f263e9ada538e00400
https://doi.org/10.1016/0165-5728(91)90017-2
https://doi.org/10.1016/0165-5728(91)90017-2
Autor:
Hefziba Lugasi, Silvia E. Hajos, Carlos Peñarroja, David Naor, Jean C. Nichols, John R. Murphy, Terry B. Strom
Publikováno v:
International Journal of Cancer. 45:163-167
We describe a new, spontaneously occurring BALBk-derived murine T-cell leukemia. The leukemic cells, designated LB, grow rapidly and progressively in the syngeneic host with no signs of effective immunological resistance. LB cells expressed the Thy-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989787552127edde77efd914becea83e
https://doi.org/10.1002/ijc.2910450129
https://doi.org/10.1002/ijc.2910450129
Autor:
Robert W. Finberg, Gopalan Soman, Jean C. Nichols, Sharon M. Wahl, J B Allen, John R. Murphy, Terry B. Strom
Publikováno v:
Science. 252:1703-1705
Infection by human immunodeficiency virus type 1 (HIV-1) is associated with cellular activation and expression of the interleukin-2 (IL-2) receptor. A genetically engineered fusion toxin, DAB486 IL-2, that contains the enzymatic site and translocatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f499a924202865830656715d362c18
https://doi.org/10.1126/science.1904628
https://doi.org/10.1126/science.1904628
Autor:
Florecita Padua, Jean C. Nichols, John R. Murphy, Kyran Bulger, Ronald P. McCaffrey, Robert Duff, German Pihan
Publikováno v:
Leukemia research. 18(2)
DAB 486 IL-2 is an IL-2-diphtheria toxin conjugate which was developed to be specifically cytotoxic to cells bearing high affinity IL-2 receptors. The high affinity IL-2 receptor is a heterodimer comprising p55 and p75 subunits. While the p75 subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21275f6ab6ae3f96f68b46e58c1bb4b6
https://pubmed.ncbi.nlm.nih.gov/8107488
https://pubmed.ncbi.nlm.nih.gov/8107488