Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Jean C. Clark"'
1
STAT3 Regulates ABCA3 Expression and Influences Lamellar Body Formation in Alveolar Type II Cells
Autor: Jean C. Clark, Valérie Besnard, Susan E. Wert, Yan Xu, Yohei Matsuzaki, Jeffrey A. Whitsett, Machiko Ikegami
Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 38:551-558
ATP-Binding Cassette A3 (ABCA3) is a lamellar body associated lipid transport protein required for normal synthesis and storage of pulmonary surfactant in type II cells in the alveoli. In this study, we demonstrate that STAT3, activated by IL-6, regu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19835cdc02ba9f870f1ce90897e08180
https://doi.org/10.1165/rcmb.2007-0311oc
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2
Foxf1haploinsufficiency reduces Notch-2 signaling during mouse lung development
Autor: Vladimir V. Kalinichenko, Jeffrey A. Whitsett, Jean C. Clark, Helena M. Yoder, Brian Shin, Robert H. Costa, Alexander M. Sapozhnikov, Galina A. Gusarova, Il-man Kim
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L521-L530
The forkhead box (Fox) f1 transcription factor is expressed in the mouse splanchnic (visceral) mesoderm, which contributes to development of the liver, gallbladder, lung, and intestinal tract. Pulmonary hemorrhage and peripheral microvascular defects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe721906854ffe11348318305d981c9
https://doi.org/10.1152/ajplung.00212.2003
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3
Role ofSonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung
Autor: Susan E. Wert, Leigh-Anne D. Miller, Anne-Karina T. Perl, Yan Xu, Jeffrey A. Whitsett, Jean C. Clark
Publikováno v: Developmental Dynamics. 231:57-71
Sonic hedgehog (Shh) was conditionally deleted in respiratory epithelial cells of the embryonic lung in vivo. Deletion of Shh before embryonic day (E) 13.5 resulted in respiratory failure at birth. While lobulation was not perturbed, the lungs were h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0f0293b85288a6b2b5938f32e6cbe
https://doi.org/10.1002/dvdy.20105
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4
SP-B deficiency causes respiratory failure in adult mice
Autor: Jay W. Tichelaar, Jeffrey A. Whitsett, Timothy E. Weaver, Machiko Ikegami, Kristin R. Melton, Lori L. Nesslein, Jean C. Clark
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 285:L543-L549
Targeted deletion of the surfactant protein (SP)-B locus in mice causes lethal neonatal respiratory distress. To assess the importance of SP-B for postnatal lung function, compound transgenic mice were generated in which the mouse SP-B cDNA was condi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80aae00f83fd660e967f4229c531ad6
https://doi.org/10.1152/ajplung.00011.2003
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5
Fibroblast Growth Factor 18 Influences Proximal Programming during Lung Morphogenesis
Autor: Lara Picard, Anne-Karina T. Perl, Nobuyuki Itoh, Jeffrey A. Whitsett, Susan E. Wert, Jay W. Tichelaar, Mildred T. Stahlman, Jean C. Clark
Publikováno v: Journal of Biological Chemistry. 277:22743-22749
The structure and functions of the airways of the lung change dramatically along their lengths. Large-diameter conducting airways are supported by cartilaginous rings and smooth muscle tissue and are lined by ciliated and secretory epithelial cells t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15deb773156ce6518583f527964b535
https://doi.org/10.1074/jbc.m202253200
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7
Pulmonary dysfunction in neonatal SP-B-deficient mice
Autor: Keisuke Tokieda, Jean C. Clark, Machiko Ikegami, Harriet S. Iwamoto, Kazushige Ikeda, Timothy E. Weaver, Jeffrey A. Whitsett, Alan H. Jobe, Keith McConnell
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 273:L875-L882
Pulmonary function was assessed in newborn wild-type and homozygous and heterozygous surfactant protein B (SP-B)-deficient mice after birth. SP-B+/+ and SP-B+/− mice became well oxygenated and survived postnatally. Although lung compliance was decr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1808b8601739babbcdb4954806bd0b1
https://doi.org/10.1152/ajplung.1997.273.4.l875
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8
Rescue of SP-B Knockout Mice with a Truncated SP-B Proprotein
Autor: Harriet S. Iwamoto, Machiko Ikegami, Timothy E. Weaver, Alan H. Jobe, Jeffrey A. Whitsett, Henry T. Akinbi, Joanette S. Breslin, Jean C. Clark
Publikováno v: Journal of Biological Chemistry. 272:9640-9647
The function of the 102-amino acid C-terminal propeptide of surfactant protein B (SP-B) was analyzed by characterizing the phenotype associated with loss of expression of this peptide domain in transgenic mice. A construct encoding the signal peptide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c326adecc89372497bd01b1b2fa34aae
https://doi.org/10.1074/jbc.272.15.9640
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9
Decreased lung compliance and air trapping in heterozygous SP-B-deficient mice
Autor: Harriet S. Iwamoto, William M. Hull, Jean C. Clark, Timothy E. Weaver, Jeffrey A. Whitsett, Alan H. Jobe, Machiko Ikegami
Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 16:46-52
Genetic ablation of the murine SP-B gene in transgenic mice caused lethal perinatal respiratory distress in homozygous offspring, whereas heterozygous SP-B (+/-) mice survived postnatally. In adult SP-B(+/-) mice, surfactant protein B mRNA and the al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4114be6fb0417771add3cba59c86940
https://doi.org/10.1165/ajrcmb.16.1.8998078
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10
Gene Structure and Expression of Human Thyroid Transcription Factor-1 in Respiratory Epithelial Cells
Autor: Chris Boutell, Jessica R. Shaw-White, Mildred T. Stahlman, Kazushige Ikeda, Jean C. Clark, Jeffrey A. Whitsett
Publikováno v: Journal of Biological Chemistry. 270:8108-8114
The human gene encoding thyroid transcription factor-1 (TTF-1), a homeodomain-containing nuclear transcription protein of the Nkx2 gene family, was isolated and characterized. Human TTF-1 was encoded by a single gene locus spanning approximately 3.3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c9d53c5ca31b75dc356a3a3464d10a
https://doi.org/10.1074/jbc.270.14.8108
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