Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jean C Manson"'
Autor:
Charlotte M Thomas, M Khalid F Salamat, Christopher de Wolf, Sandra McCutcheon, A Richard Alejo Blanco, Jean C Manson, Nora Hunter, E Fiona Houston
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0293845 (2023)
Efforts to prevent human-to-human transmission of variant Creutzfeldt-Jakob disease (vCJD) by contaminated blood would be aided by the development of a sensitive diagnostic test that could be routinely used to screen blood donations. As blood samples
Externí odkaz:
https://doaj.org/article/63ea9b6a06dd431dbf9764fc118665ff
Autor:
M Khalid F Salamat, A Richard Alejo Blanco, Sandra McCutcheon, Kyle B C Tan, Paula Stewart, Helen Brown, Allister Smith, Christopher de Wolf, Martin H Groschup, Dietmar Becher, Olivier Andréoletti, Marc Turner, Jean C Manson, E Fiona Houston
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009276 (2021)
Variant Creutzfeldt-Jakob disease (vCJD) is a human prion disease resulting from zoonotic transmission of bovine spongiform encephalopathy (BSE). Documented cases of vCJD transmission by blood transfusion necessitate on-going risk reduction measures
Externí odkaz:
https://doaj.org/article/6ecdbe62cbea47acad58e4b2fc9e1d09
Autor:
Cassandra M Burke, Kenneth M K Mark, Daniel J Walsh, Geoffrey P Noble, Alexander D Steele, Abigail B Diack, Jean C Manson, Joel C Watts, Surachai Supattapone
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008875 (2020)
Prions are unorthodox pathogens that cause fatal neurodegenerative diseases in humans and other mammals. Prion propagation occurs through the self-templating of the pathogenic conformer PrPSc, onto the cell-expressed conformer, PrPC. Here we study th
Externí odkaz:
https://doaj.org/article/56f2eed8818d434daa5cbc4eb00e3299
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006642 (2017)
Externí odkaz:
https://doaj.org/article/e6666b7fddfe4ec4add8ba455444f144
Autor:
Jamie McQueen, Tomás J Ryan, Sean McKay, Katie Marwick, Paul Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David J A Wyllie, Seth G N Grant, Barry W McColl, Noboru H Komiyama, Giles E Hardingham
Publikováno v:
eLife, Vol 6 (2017)
Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically. The GluN2B cytoplasmic C-terminal domain (CTD) represents an alternative therapeutic target since it pot
Externí odkaz:
https://doaj.org/article/f177a251648f4e64b60117c9b4f5e466
Autor:
James Alibhai, Richard A Blanco, Marcelo A Barria, Pedro Piccardo, Byron Caughey, V Hugh Perry, Tom C Freeman, Jean C Manson
Publikováno v:
PLoS Biology, Vol 14, Iss 11, p e1002579 (2016)
Protein misfolding is common across many neurodegenerative diseases, with misfolded proteins acting as seeds for "prion-like" conversion of normally folded protein to abnormal conformations. A central hypothesis is that misfolded protein accumulation
Externí odkaz:
https://doaj.org/article/fa81a882e71a410881ef44e8fa45620f
Autor:
Isobel J Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B Diack, Katherine A B Kellett, Pedro Piccardo, Jean C Manson, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159119 (2016)
The cellular prion protein (PrPC) has been proposed to play an important role in the pathogenesis of Alzheimer's disease. In cellular models PrPC inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a red
Externí odkaz:
https://doaj.org/article/661eb766a5da451a8aa047e01b1089fe
Autor:
Victoria Lewis, Isobel J Whitehouse, Herbert Baybutt, Jean C Manson, Steven J Collins, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31754 (2012)
There is increasing evidence of molecular and cellular links between Alzheimer's disease (AD) and prion diseases. The cellular prion protein, PrP(C), modulates the post-translational processing of the AD amyloid precursor protein (APP), through its i
Externí odkaz:
https://doaj.org/article/08e189dc9f87415ca7e578f29a71edff
Autor:
Laura McCulloch, Karen L Brown, Barry M Bradford, John Hopkins, Mick Bailey, Klaus Rajewsky, Jean C Manson, Neil A Mabbott
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002402 (2011)
Prion diseases are characterised by the accumulation of PrP(Sc), an abnormally folded isoform of the cellular prion protein (PrP(C)), in affected tissues. Following peripheral exposure high levels of prion-specific PrP(Sc) accumulate first upon folli
Externí odkaz:
https://doaj.org/article/4907cbe0c0c0411d8a32bde29ccc06df
Autor:
Sandra McCutcheon, Anthony Richard Alejo Blanco, E Fiona Houston, Christopher de Wolf, Boon Chin Tan, Antony Smith, Martin H Groschup, Nora Hunter, Valerie S Hornsey, Ian R MacGregor, Christopher V Prowse, Marc Turner, Jean C Manson
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23169 (2011)
Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by t
Externí odkaz:
https://doaj.org/article/9787d6f5dbc047c7b4ad98b09f517ea9