Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jean Buteau"'
Autor:
John P. Kennelly, Stephanie Carlin, Tingting Ju, Jelske N. van der Veen, Randal C. Nelson, Jean Buteau, Aducio Thiesen, Caroline Richard, Ben P. Willing, René L. Jacobs
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 999-1021 (2021)
Background & Aims: Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved in the development of colit
Externí odkaz:
https://doaj.org/article/13b401fe7615444286f1361c641b7deb
Autor:
John P. Kennelly, Jelske N. van der Veen, Randal C. Nelson, Kelly-Ann Leonard, Rick Havinga, Jean Buteau, Folkert Kuipers, René L. Jacobs
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1695-1708 (2018)
De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-α (CTα) is required for VLDL secretion. To determine the precise role of de novo PC synthesis in intestinal lipid metabolism, we deleted CTα exclusively in the
Externí odkaz:
https://doaj.org/article/92c736a4f02e47748548008985011563
Publikováno v:
Cells, Vol 9, Iss 1, p 168 (2020)
Nor1, the third member of the Nr4a subfamily of nuclear receptor, is garnering increased interest in view of its role in the regulation of glucose homeostasis. Our previous study highlighted a proapoptotic role of Nor1 in pancreatic beta cells and sh
Externí odkaz:
https://doaj.org/article/e281ebc2d26c422196ffeed9f7819176
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64957 (2013)
Type 2 diabetes is characterized by both insulin resistance and progressive deterioration of β-cell function. The forkhead transcription factor FoxO1 is a prominent mediator of insulin signaling in β-cells. We reasoned that identification of FoxO1
Externí odkaz:
https://doaj.org/article/9f0cc9df068146c08f5213c87d61ec22
Autor:
Patrick E. MacDonald, Austin Bautista, Ying Wayne Wang, Jean Buteau, Mourad Ferdaoussi, Aliya F. Spigelman, Sophie L. Lewandowski, Matthew J. Merrins, Tamadher A. Alghamdi, Yaxing Jin, Nancy Smith, Haopeng Lin, Jocelyn E. Manning Fox, Kunimasa Suzuki
Publikováno v:
Diabetes
SUMOylation reduces oxidative stress and preserves islet mass at the expense of robust insulin secretion. To investigate a role for the deSUMOylating enzyme sentrin-specific protease 1 (SENP1) following metabolic stress, we put pancreas/gut-specific
Autor:
Caroline Richard, Jean Buteau, John P. Kennelly, Tingting Ju, Stephanie Carlin, Ben P. Willing, Jelske N. van der Veen, Aducio Thiesen, René L. Jacobs, Randal Nelson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 999-1021 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved in the development of coliti
Publikováno v:
Canadian Journal of Diabetes. 46:S30
Publikováno v:
Canadian Journal of Diabetes. 46:S7
Autor:
Patrick E MacDonald, Jean Buteau, Matthew J Merrins, Jocelyn E. Manning Fox, Ying Wayne Wang, Austin Bautista, Yaxing Jin, Sophie L Lewandowski, Tamadher A. Alghamdi, Mourad Ferdaoussi, Kunimasa Suzuki, Aliya F Spigelman, Nancy Smith, Haopeng Lin
SUMOylation reduces oxidative stress and preserves islet mass at the expense of robust insulin secretion. To investigate a role for the deSUMOylating enzyme sentrin-specific protease 1 (SENP1) following metabolic stress, we put pancreas/gut-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663aa93960a3917e4cf55524580541c1
https://doi.org/10.2337/figshare.16435176
https://doi.org/10.2337/figshare.16435176
Autor:
Hongbo Qiu, Catherine J. Field, Kaiyuan Yang, Erinn Mills, Jean Buteau, Benjamin P. Willing, Catherine B. Chan, Carla Sosa Alvarado, Janelle M Fouhse, Tingting Ju
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 321(3)
Neonatal antibiotics administered to human infants initiate gut microbiota dysbiosis that may have long-term effects on body weight and metabolism. We examined antibiotic-induced adaptations in pancreatic islets of the piglet, a well-accepted model o