Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jean Brochier"'
Publikováno v:
British Journal of Haematology. 114:406-413
Human multiple myeloma (MM) purified tumour cells readily undergo apoptosis in vitro. Interleukin 6 (IL-6), a main growth factor of tumour cells, has enabled the development of IL-6-dependent MM cell lines. Recently, we developed anti-gp130 monoclona
Publikováno v:
European Journal of Immunology. 31:259-264
Therapeutic targeting of soluble molecules such as cytokines can be achieved with monoclonal antibodies (mAb). Anti-IL-6 mAb have been shown to form circulating complexes, resulting in the increase of the half-life of the cytokine in vivo. In IL-6-re
Publikováno v:
British Journal of Haematology. 111:626-634
Autor:
Martine Ferlin-Bezombes, Michel Jourdan, Janny Liautard, Jean Brochier, Jean-François Rossi, Bernard Klein
Publikováno v:
The Journal of Immunology. 161:2692-2699
IFN-α is used as a maintenance therapy in patients with multiple myeloma, but its benefit is a matter of controversy. In vitro studies show that IFN-α can both stimulate and inhibit myeloma cell proliferation. We have tested the effect of IFN-α on
Autor:
Bernard Klein, Jean Brochier, Eric Legouffe, Mira Horvathova, Jean François Rossi, Michel Jourdan, John Wijdenes, Martine Ferlin, Janny Liautard
Publikováno v:
British Journal of Haematology. 100:637-646
Syndecan-1 is a cell membrane proteoglycan that binds extracellular matrix components and various growth factors. It is expressed only on malignant plasma cells in bone marrow samples from patients with multiple myeloma (MM). Several reports have sug
Publikováno v:
European Journal of Immunology. 27:794-797
Six cytokines of the interleukin (IL)-6 family involved in various inflammatory or tumoral diseases share the same gp130 signal transducer chain. We made a panel of anti-gp130 monoclonal antibodies (mAb) to study the structure and function of the gp1
Autor:
Peter C. Heinrich, Jean Brochier, Stefan Rose-John, Michael Kalai, Hervé Brailly, Danielle Morelle, Axel Wollmer, Felix A. Montero-Julian, Joachim Grötzinger
Publikováno v:
European Journal of Biochemistry. 238:714-723
The alpha-subunit of interleukin-6 (IL-6) receptor is a member of the hematopoietin receptor family. The alignment of its amino acid sequence with those of other members of this family (human somatotropin receptor/murine IL-3 receptor beta and human
Autor:
Jean Brochier, J P Gaillard, John Wijdenes, Christian Gisselbrecht, Jean-Yves Blay, Gabarre J, Dominique Emilie, Eric Billaud, Martine Raphael, B Jarrousse
Publikováno v:
Blood. 84:2472-2479
Increased interleukin-6 (IL-6) production and expression by malignant cells of the IL-6 receptor has been evidenced in a subgroup of non- Hodgkin's lymphomas, suggesting that this cytokine plays a role in lymphoma growth and in B clinical symptoms. I
Publikováno v:
Arthritis & Rheumatism. 35:49-54
Objective. We sought to compare the frequencies of precursors producing IgM rheumatoid factors (IgM-RFs) in synovial fluid and peripheral blood B cells from patients with rheumatoid arthritis (RA). Methods. We used limiting-dilution analysis of Epste
Autor:
Jean-Michel Boiron, John Wijdenes, C Clement, M Merlin, Michel Jourdan, Jean Brochier, Bernard Klein, Xue Guang Zhang, B Morel-Fournier, Janny Liautard
Publikováno v:
Blood. 78:1198-1204
A patient with primary plasma cell leukemia resistant to chemotherapy was treated for 2 months with daily intravenous injections of anti- interleukin-6 (IL-6) monoclonal antibodies (MoAbs). The patient's clinical status improved throughout the treatm