Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jean Belehradek"'
Autor:
Tomazˇ Jarm, Lluis M. Mir, Maja Cˇemazˇar, Jean Belehradek, Damijan Miklavcˇicˇ, Gregor Sersˇa
Publikováno v:
Bioelectrochemistry and Bioenergetics. 43:279-283
Electrochemotherapy combines chemotherapy with electric pulses in order to potentiate anti-tumor effectiveness of chemotherapeutic drugs. Electrochemotherapy with drugs that normally do not accumulate in the tumor cells in sufficient quantities, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e22f12695e523812a0afc58e92673c6c
https://doi.org/10.1016/s0302-4598(96)05194-x
https://doi.org/10.1016/s0302-4598(96)05194-x
Autor:
Christian Domenge, Bernard Luboinski, Lluis M. Mir, Jean Belehradek, Guy Schwaab, Thierry de Baere, Stéphane Orlowski
Publikováno v:
Cancer. 77:956-963
BACKGROUND Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in the tissue, allow BLM delivery inside the cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35876163e003643377ae64c4753a93a
https://doi.org/10.1002/(sici)1097-0142(19960301)77:5<956::aid-cncr23>3.0.co
https://doi.org/10.1002/(sici)1097-0142(19960301)77:5<956::aid-cncr23>3.0.co
Publikováno v:
Experimental Cell Research. 217:506-516
The determination of whether a cell dies by apoptosis as opposed to necrosis is usually best made on the basis of distinct structural changes in the chromatin. These changes include extensive condensation of the chromatin and DNA fragmentation. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5d777732e090aa36177854fc84af13
https://doi.org/10.1006/excr.1995.1116
https://doi.org/10.1006/excr.1995.1116
Autor:
Claude Roth, Lluis M. Mir, Philippe Kourilsky, F. Quintin-Colonna, Stéphane Orlowski, Jean Belehradek, Didier Fradelizi
Publikováno v:
Journal of Immunotherapy. 17:30-38
Electrochemotherapy is an antitumor treatment that combines a cytotoxic drug with the local administration of electric pulses delivered at the tumor site. We previously found that in mice the cure rate of subcutaneous transplanted tumors treated by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36a551fe103cd239ddd8ce58c38e433
https://doi.org/10.1097/00002371-199501000-00004
https://doi.org/10.1097/00002371-199501000-00004
Autor:
Lluis M. Mir, Christian Domenge, Bernard Luboinski, Jean Belehradek, Michel Belehradek, Stéphane Orlowski
Publikováno v:
Cancer. 72:3694-3700
Background. Electrochemotherapy is a new antitumor treatment consisting of electrical pulses administered to the tumor several minutes after intravenous injection of bleomycin. In mice, important antitumor effects were observed on subcutaneously tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1081513e40ca0f73b1118b001446494
https://doi.org/10.1002/1097-0142(19931215)72:12<3694::aid-cncr2820721222>3.0.co
https://doi.org/10.1002/1097-0142(19931215)72:12<3694::aid-cncr2820721222>3.0.co
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b55fed6a03766bd1cb0cac69b217954
https://doi.org/10.1002/chin.199213222
https://doi.org/10.1002/chin.199213222
Publikováno v:
Biochemical Pharmacology. 42:S67-S75
We observed previously in vitro that the cytotoxicity of bleomycin (BLM), an anticancer drug in current use, was greatly potentiated by exposing cultured cells to appropriately chosen electric pulses. We then showed in vivo, on tumor-bearing mice, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cadccaee757c8a68c3a1a43e26e50b
https://doi.org/10.1016/0006-2952(91)90394-k
https://doi.org/10.1016/0006-2952(91)90394-k
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:68-72
In cell culture the cytotoxicity of some anticancer drugs, especially bleomycin, can be greatly enhanced by exposing cells to non-cytotoxic electric pulses. Nude or conventional mice bearing subcutaneous transplanted tumours were treated with intramu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681b6097a3837ae26f2c73a888001136
https://doi.org/10.1016/0277-5379(91)90064-k
https://doi.org/10.1016/0277-5379(91)90064-k
Publikováno v:
Biochemical and Biophysical Research Communications. 173:259-264
A method for the preparation of 57 Co-labelled bleomycin (BLM) possessing very high specific radioactivity and suitable for use at the nanomolar concentration range is described, and validated using a biological assay. Chelation of BLM with Co(II) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34728aabd418acfcb1e4054ef4f8fc80
https://doi.org/10.1016/s0006-291x(05)81050-2
https://doi.org/10.1016/s0006-291x(05)81050-2
Autor:
Bernard Psaume, Serge Fermandjian, Monique Monnot, Jean Belehradek, Elie Lescot, Olivier Mauffret, Jean-Marie Saucier, Valérie Simon
Publikováno v:
FEBS Letters. 273:71-74
UV-absorption and circular dichroism (CD) experiments showed that ellipticine derivatives may interact with DNA according to 3 possible binding modes depending on their structure and concentration. The first mode concerned intercalation of 1-methyl-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8448d4a8e7643d727df4d1fcfcfd9759
https://doi.org/10.1016/0014-5793(90)81053-q
https://doi.org/10.1016/0014-5793(90)81053-q