Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jean Bedard"'
Publikováno v:
Geological Journal. 58:523-533
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb433888a74fde94a4a62788bd5dd11
https://doi.org/10.1002/gj.4609
https://doi.org/10.1002/gj.4609
Autor:
Olivier Nicolas, Samuel S. Lee, Maribel Rodriguez-Torres, Curtis Cooper, Eric Lawitz, Jean Bedard, Frank H. Anderson, Peter Ghali, Nathalie Chauret, L. Proulx, Isabel Boivin, Roch Thibert
Publikováno v:
Journal of Hepatology. 51:39-46
Background/Aims VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC 50 values versus genotype 1a/1b replicons. Methods The antiviral activity, pharmacokinetics and tolerability of VCH-759 administered as monot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfea919b6e72f74ec5da8e09d9295678
https://doi.org/10.1016/j.jhep.2009.03.015
https://doi.org/10.1016/j.jhep.2009.03.015
Autor:
Maia M. Cherney, Nghe Nguyen-Ba, Constantin G. Yannopoulos, Laval Chan, Kenneth K.-S. Ng, Nicolas Morin, Moulay Hicham Alaoui-Ismaili, Richard Bethell, Meitian Wang, Jean Bedard, Michael N.G. James
Publikováno v:
Journal of Biological Chemistry. 278:9489-9495
X-ray crystal structures of two non-nucleoside analogue inhibitors bound to hepatitis C virus NS5B RNA-dependent RNA polymerase have been determined to 2.0 and 2.9 A resolution. These noncompetitive inhibitors bind to the same site on the protein, ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a23853eab3f87feed20e198e0b34b3c4
https://doi.org/10.1074/jbc.m209397200
https://doi.org/10.1074/jbc.m209397200
Autor:
Robert W. Buckheit, Mary E. Moreno, Mark Bogan, Bare Christopher B, Cheryl A. Stoddart, Valerie Linquist-Stepps, Joseph M. McCune, Robert F. Rando, Jean Bedard, Alberto Gobbi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:783-786
Oral administration of 2′-deoxy-3′-oxa-4′-thiocytidine (BCH-10652), a nucleoside analog structurally similar to lamivudine (3TC), caused dose-dependent inhibition of viral replication in SCID-hu Thy/Liv mice infected with human immunodeficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671199117c4d0f6f7a1d62dadf9aa6f7
https://doi.org/10.1128/aac.44.3.783-786.2000
https://doi.org/10.1128/aac.44.3.783-786.2000
Autor:
Laval Chan, Jean Bedard, Tomislav Stefanac, Haolun Jin, Wei Wang, Jean-François Lavallée, Suzanne May
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2583-2586
Structure-activity relationship studies on our newly identified anti-HCMV compounds, the 1,6-naphthyridines led to the identification of isoquinoline-6-carboxamides as potent and selective anti-HCMV agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28d7c129ebb0e554796fc99ef01ebea
https://doi.org/10.1016/s0960-894x(99)00435-7
https://doi.org/10.1016/s0960-894x(99)00435-7
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3561-3566
We have recently described the discovery of new leads in the area of anti-HCMV research. Further structure - activity relationship studies have allowed us to identify potent and selective anti-HCMV nucleotide analogs. The synthesis as well as structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d04619d3fbbefcb916cc032cdecc9ed
https://doi.org/10.1016/s0960-894x(98)00649-0
https://doi.org/10.1016/s0960-894x(98)00649-0
Autor:
Alan D. Borthwick, Haloun Jin, Leonard Yuen, Tarek S. Mansour, Gordon G. Weingarten, Mirek Tomaszewski, Jean Bedard, Zhouhan Hu, Terry M. Haley, Wei Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:365-370
Mechanism based inhibitors of HCMV protease have been designed based on the monocyclic beta-lactam nucleus, which have been shown to acylate the viral enzyme in a time dependent manner. SAR in a series of monocyclic beta-lactam N-ureas, has defined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622a643a453be69d4e112d9b316a78ef
https://doi.org/10.1016/s0960-894x(98)00032-8
https://doi.org/10.1016/s0960-894x(98)00032-8
Autor:
Laval Chan, Guy Falardeau, Constantin G. Yannopoulos, Hugo Lachance, Annie St-Pierre, Marc Drouin, Jean Bedard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1693-1695
A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5ac13e48495bdc4cf948eab26c95ca
https://doi.org/10.1016/j.bmcl.2005.01.050
https://doi.org/10.1016/j.bmcl.2005.01.050
Autor:
Guy Falardeau, Laval Chan, Tomislav Stefanac, Jean-François Lavallée, Suzanne May, Jean Bedard, Haolun Jin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:103-105
1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce08a09a3b6fa1549479816ca26c846
https://doi.org/10.1016/s0960-894x(00)00607-7
https://doi.org/10.1016/s0960-894x(00)00607-7
Autor:
Jean Bedard, Gordon G. Weingarten, Zhouhan Hu, Terry M. Haley, Haloun Jin, Alan D. Borthwick, Leonard Yuen, Wei Wang, Mirek Tomaszewski, Tarek S. Mansour
Publikováno v:
ChemInform. 29
Mechanism based inhibitors of HCMV protease have been designed based on the monocyclic beta-lactam nucleus, which have been shown to acylate the viral enzyme in a time dependent manner. SAR in a series of monocyclic beta-lactam N-ureas, has defined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf0fa6aafc0a13be89161f3dc0b73eb7
https://doi.org/10.1002/chin.199821217
https://doi.org/10.1002/chin.199821217