Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

Autor: Naser Ansari-Pour, Yonglan Zheng, Toshio F. Yoshimatsu, Ayodele Sanni, Mustapha Ajani, Jean-Baptiste Reynier, Avraam Tapinos, Jason J. Pitt, Stefan Dentro, Anna Woodard, Padma Sheila Rajagopal, Dominic Fitzgerald, Andreas J. Gruber, Abayomi Odetunde, Abiodun Popoola, Adeyinka G. Falusi, Chinedum Peace Babalola, Temidayo Ogundiran, Nasiru Ibrahim, Jordi Barretina, Peter Van Loo, Mengjie Chen, Kevin P. White, Oladosu Ojengbede, John Obafunwa, Dezheng Huo, David C. Wedge, Olufunmilayo I. Olopade

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Breast cancer heterogeneity and tumour evolutionary trajectories remain largely unknown among women of African ancestry. Here, the authors perform whole genome and transcriptome sequencing of Nigerian breast cancer patients and identify unique evolut

Externí odkaz: https://doaj.org/article/7a5145c553b747468c2fef56d8af5e4f

A Unified Modular Framework to Incorporate Structural Dependency in Spatial Omics Data

Autor: Jiayu Su, Jean-Baptiste Reynier, Xi Fu, Guojie Zhong, Jiahao Jiang, Rydberg Supo Escalante, Yiping Wang, Benjamin Izar, David A Knowles, Raul Rabadan

Spatial omics technologies, such as spatial transcriptomics, allow the identification of spatially organized biological processes, while presenting computational challenges for existing analysis approaches that ignore spatial dependencies. Here we in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17c14f0703f8b7d9d53ae8106f028002
https://doi.org/10.1101/2022.10.25.513785

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

Autor: Stefan C. Dentro, Padma Sheila Rajagopal, Anna Woodard, Avraam Tapinos, Ayodele Sanni, Chinedum P. Babalola, Olufunmilayo I. Olopade, Jason J. Pitt, David C. Wedge, Oladosu Ojengbede, Jean-Baptiste Reynier, Kevin P. White, Abayomi Odetunde, Nasiru Ibrahim, Dominic Fitzgerald, Mengjie Chen, Peter Van Loo, Yonglan Zheng, John Obafunwa, Abiodun Popoola, Jordi Barretina, Andreas J. Gruber, Temidayo O. Ogundiran, Naser Ansari-Pour, Dezheng Huo, Mustapha Akanji Ajani, Toshio F. Yoshimatsu, Adeyinka G. Falusi

Publikováno v: Ansari-pour, N, Zheng, Y, F. Yoshimatsu, T, Sanni, A, Ajani, M, Reynier, J-B, Tapinos, A, J. Pitt, J, Dentro, S, Woodard, A, Sheila Rajagopal, P, Fitzgerald, D, Gruber, A, Odetunde, A, Popoola, A, Falusi, A, Peace Babalola, C, Ogundiran, T, Ibrahim, N, Barretina, J, Van Loo, P, Chen, M, P. White, K, Ojengbede, O, Obafunwa, J, Huo, D, Wedge, D & Olopade, O I 2021, ' Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes ', Nature Communications, vol. 12, 6946 . https://doi.org/10.1038/s41467-021-27079-w
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Black women across the African diaspora experience more aggressive breast cancer with higher mortality rates than white women of European ancestry. Although inter-ethnic germline variation is known, differential somatic evolution has not been investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14dac1e41077e5429990a77764f9072

Abstract PD7-06: Unstable mutational profile and heterogeneity of residual breast tumor following neoadjuvant therapy from comprehensive genomic and transcriptomic sequencing

Autor: Abiola Ibraheem, Nike Beaubier, Jean Baptiste Reynier, Anna Woodard, Rita Nanda, Elisabeth Sveen, Galina Khramtsova, Minoru Miyashita, Dezheng Huo, Padma Sheila Rajagopal, Kevin P. White, Masaya Hattori, Olufunmilayo I. Olopade, Joshua S.K. Bell, Fang Liu, Toshio F. Yoshimatsu, Yonglan Zheng, Nora Jaskowiak, Benjamin D. Leibowitz, Gini F. Fleming

Publikováno v: Cancer Research. 81:PD7-06

Background: In patients with early breast cancer, neoadjuvant therapy is widely performed as standard of care. While the molecular targeting strategy makes progress in HER2 positive breast cancer, the optimal regimens for ER+/HER2- breast cancer (BC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::652c206e6232a7bde771b5d7ed97bf47
https://doi.org/10.1158/1538-7445.sabcs20-pd7-06

Additional file 4: Figure S2. of In vivo imaging of epithelial wound healing in the cnidarian Clytia hemisphaerica demonstrates early evolution of purse string and cell crawling closure mechanisms

Autor: Kamran, Zach, Zellner, Katie, Kyriazes, Harry, Kraus, Christine, Jean-Baptiste Reynier, Malamy, Jocelyn

20 mM hydroxyurea treatment completely inhibits cell division in the Clytia medusa exumbrella. 7 day old animals were labeled with EdU for 24 h in the absence (A,B) or presence (C,D) of 20 mM hydroxyurea. B and D show Hoechst staining in the same ani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71024da6fbc78c0dd828b84912749751