The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells.

Autor: Arnault Graindorge, Karine Frénal, Damien Jacot, Julien Salamun, Jean Baptiste Marq, Dominique Soldati-Favre

Publikováno v: PLoS Pathogens, Vol 12, Iss 1, p e1005388 (2016)

Many members of the phylum of Apicomplexa have adopted an obligate intracellular life style and critically depend on active invasion and egress from the infected cells to complete their lytic cycle. Toxoplasma gondii belongs to the coccidian subgroup

Externí odkaz: https://doaj.org/article/cb0ac33ed2514003b5a3309d10ac3315

Toxoplasma gondii HOOK-FTS-HIP Complex is Critical for Secretory Organelle Discharge during Motility, Invasion, and Egress

Autor: David J. Dubois, Sylia Chehade, Jean-Baptiste Marq, Kannan Venugopal, Bohumil Maco, Albert Tell I. Puig, Dominique Soldati-Favre, Sabrina Marion

Publikováno v: mBio.

Toxoplasma gondii affects between 30 and 80% of the human population, poses a life-threatening risk to immunocompromised individuals, and is a cause of abortion and birth defects following congenital transmission. T. gondii belongs to the phylum of A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52a36c6cdf24e391b64fa665a3a3c4bc
https://doi.org/10.1128/mbio.00458-23

CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites

Autor: Volker Heussler, Hugo Bisio, Jean-Baptiste Marq, Paul-Christian Burda, Dominique Soldati-Favre

Publikováno v: mSphere, Vol 5, Iss 6 (2020)
mSphere, Vol. 5, No 6 (2020) pp. e01001-20
Burda, Paul-Christian; Bisio, Hugo; Marq, Jean-Baptiste; Soldati-Favre, Dominique; Heussler, Volker (2020). CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites. mSphere, 5(6) American Society for Microbiology 10.1128/mSphere.01001-20
mSphere

The coordinated release of apicomplexan parasites from infected host cells prior to reinvasion is a critical process for parasite survival and the spread of infection. While Toxoplasma tachyzoites and Plasmodium blood stages induce a fast disruption

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f371d629bf33d4e8f3c510918adde433
https://journals.asm.org/doi/10.1128/mSphere.01001-20

Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases

Autor: Jean-Baptiste Marq, Francesca Tessaro, Juha Vahokoski, Budhaditya Mukherjee, Dominique Soldati-Favre, Leonardo Scapozza, Inari Kursula

Publikováno v: EMBO Journal (2018) P. e98047

Toxoplasma gondii aspartyl protease 3 (TgASP3) phylogenetically clusters with Plasmodium falciparum Plasmepsins IX and X (PfPMIX, PfPMX). These proteases are essential for parasite survival, acting as key maturases for secreted proteins implicated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35873667a2831047b21332a33b35deb5
https://doi.org/10.15252/embj.201798047

Crosstalk between PKA and PKG controls pH-dependent host cell egress of

Autor: Yonggen, Jia, Jean-Baptiste, Marq, Hugo, Bisio, Damien, Jacot, Christina, Mueller, Lu, Yu, Jyoti, Choudhary, Mathieu, Brochet, Dominique, Soldati-Favre

Publikováno v: The EMBO journal. 36(21)

Toxoplasma gondii encodes three protein kinase A catalytic (PKAc1‐3) and one regulatory (PKAr) subunits to integrate cAMP‐dependent signals. Here, we show that inactive PKAc1 is maintained at the parasite pellicle by interacting with acylated PKA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbf2b559a9c8435afc68c3559882e385
https://pubmed.ncbi.nlm.nih.gov/29030485