Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Jean A. Quinn"'
Autor:
Norman J. Galbraith, Jean A. Quinn, Sara Sf Al-Badran, Kathryn A.F. Pennel, Lily V.S. Hillson, Phimmada Hatthakarnkul, Molly McKenzie, Noori Maka, Lynette Loi, Mikaela Frixou, Colin W. Steele, Campbell S. Roxburgh, Paul G. Horgan, Donald C. McMillan, Joanne Edwards
Publikováno v:
Translational Oncology, Vol 48, Iss , Pp 102064- (2024)
Background: Transforming growth factor β-activated protein kinase-1 (TAK1) plays an important role in MAPK and NFκB pathways and has been associated with colorectal cancer. The aim of this study was to determine how cytoplasmic and juxtanuclear pun
Externí odkaz:
https://doaj.org/article/f77b384652bb4325a5076d3ce2c361b8
Autor:
Kathryn A. F. Pennel, Phimmada Hatthakarnkul, Colin S. Wood, Guang-Yu Lian, Sara S. F. Al-Badran, Jean A. Quinn, Assya Legrini, Jitwadee Inthagard, Peter G. Alexander, Hester van Wyk, Ahmad Kurniawan, Umar Hashmi, Michael A. Gillespie, Megan Mills, Aula Ammar, Jennifer Hay, Ditte Andersen, Colin Nixon, Selma Rebus, David K. Chang, Caroline Kelly, Andrea Harkin, Janet Graham, David Church, Ian Tomlinson, Mark Saunders, Tim Iveson, Tamsin R. M. Lannagan, Rene Jackstadt, Noori Maka, Paul G. Horgan, Campbell S. D. Roxburgh, Owen J. Sansom, Donald C. McMillan, Colin W. Steele, Nigel B. Jamieson, James H. Park, Antonia K. Roseweir, Joanne Edwards
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal transduction in the development and progression of solid tumors. I
Externí odkaz:
https://doaj.org/article/3b63169b435447a19a5fb490ee037279
Autor:
Molly McKenzie, Guang-Yu Lian, Kathryn A.F. Pennel, Jean A. Quinn, Nigel B. Jamieson, Joanne Edwards
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32904- (2024)
The NFκB pathway, known as the central regulator of inflammation, has a well-established role in colorectal cancer (CRC) initiation, progression, and therapy resistance. Due to the pathway's overarching roles in CRC, there have been efforts to chara
Externí odkaz:
https://doaj.org/article/69cded1c50c04455bef37af3ffae8ba0
Autor:
Kathryn AF Pennel, Jean A Quinn, Colin Nixon, Jitwadee Inthagard, Hester C vanWyk, David Chang, Selma Rebus, GPOL Group, Jennifer Hay, Noori N Maka, Campbell SD Roxburgh, Paul G Horgan, Donald C McMillan, James H Park, Antonia K Roseweir, Colin W Steele, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 6, Pp 509-520 (2022)
Abstract CXCL8 is an inflammatory chemokine elevated in the colorectal cancer (CRC) tumour microenvironment. CXCR2, the major receptor for CXCL8, is predominantly expressed by neutrophils. In the cancer setting, CXCL8 plays important roles in neutrop
Externí odkaz:
https://doaj.org/article/2587601ff4f442529788ab8eca02bcc0
Autor:
Warapan Numprasit, Supaporn Yangngam, Jaturawitt Prasopsiri, Jean A. Quinn, Joanne Edwards, Chanitra Thuwajit
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundTumoral hypoxia is associated with aggressiveness in many cancers including breast cancer. However, measuring hypoxia is complicated. Carbonic anhydrase IX (CAIX) is a reliable endogenous marker of hypoxia under the control of the master re
Externí odkaz:
https://doaj.org/article/9ad65aca7cb6442ab68024bda5c5c41a
Autor:
Colin S. Wood, Kathryn A.F. Pennel, Holly Leslie, Assya Legrini, Andrew J. Cameron, Lydia Melissourgou-Syka, Jean A. Quinn, Hester C. van Wyk, Jennifer Hay, Antonia K. Roseweir, Colin Nixon, Campbell S.D. Roxburgh, Donald C. McMillan, Andrew V. Biankin, Owen J. Sansom, Paul G. Horgan, Joanne Edwards, Colin W. Steele, Nigel B. Jamieson
Publikováno v:
Cancer Research. 83:1329-1344
Strong immune responses in primary colorectal cancer correspond with better patient survival following surgery compared with tumors with predominantly stromal microenvironments. However, biomarkers to identify patients with colorectal cancer liver me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::774945f4abcfa2bf86be777d51c0e348
https://doi.org/10.1158/0008-5472.can-22-2794
https://doi.org/10.1158/0008-5472.can-22-2794
Autor:
Nigel B. Jamieson, Colin W. Steele, Joanne Edwards, Paul G. Horgan, Owen J. Sansom, Andrew V. Biankin, Donald C. McMillan, Campbell S.D. Roxburgh, Colin Nixon, Antonia K. Roseweir, Jennifer Hay, Hester C. van Wyk, Jean A. Quinn, Lydia Melissourgou-Syka, Andrew J. Cameron, Assya Legrini, Holly Leslie, Kathryn A.F. Pennel, Colin S. Wood
All supplementary figures and supplementary tables 1 and 2 from the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403e64c8ec0da6f59bb48f6e55065ecc
https://doi.org/10.1158/0008-5472.22633296.v1
https://doi.org/10.1158/0008-5472.22633296.v1
Autor:
Nigel B. Jamieson, Colin W. Steele, Joanne Edwards, Paul G. Horgan, Owen J. Sansom, Andrew V. Biankin, Donald C. McMillan, Campbell S.D. Roxburgh, Colin Nixon, Antonia K. Roseweir, Jennifer Hay, Hester C. van Wyk, Jean A. Quinn, Lydia Melissourgou-Syka, Andrew J. Cameron, Assya Legrini, Holly Leslie, Kathryn A.F. Pennel, Colin S. Wood
Gene Set Enrichment Analysis results obtained by interrogating ranked list of differentially expressed KM high vs KM low genes against the REACTOME curated gene set database using ClusterProfiler package
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52eb2629c57087ccdf7531fa25bf1bf6
https://doi.org/10.1158/0008-5472.22633287.v1
https://doi.org/10.1158/0008-5472.22633287.v1
Autor:
Nigel B. Jamieson, Colin W. Steele, Joanne Edwards, Paul G. Horgan, Owen J. Sansom, Andrew V. Biankin, Donald C. McMillan, Campbell S.D. Roxburgh, Colin Nixon, Antonia K. Roseweir, Jennifer Hay, Hester C. van Wyk, Jean A. Quinn, Lydia Melissourgou-Syka, Andrew J. Cameron, Assya Legrini, Holly Leslie, Kathryn A.F. Pennel, Colin S. Wood
Supplementary details regarding methods and materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c84d91b354ecd603c7bb4d3097c5852
https://doi.org/10.1158/0008-5472.22633293.v1
https://doi.org/10.1158/0008-5472.22633293.v1
Autor:
Nigel B. Jamieson, Colin W. Steele, Joanne Edwards, Paul G. Horgan, Owen J. Sansom, Andrew V. Biankin, Donald C. McMillan, Campbell S.D. Roxburgh, Colin Nixon, Antonia K. Roseweir, Jennifer Hay, Hester C. van Wyk, Jean A. Quinn, Lydia Melissourgou-Syka, Andrew J. Cameron, Assya Legrini, Holly Leslie, Kathryn A.F. Pennel, Colin S. Wood
SpatialDecon derived immune cell counts aggregated by Region, KM grade and KRAS status with pairwise comparison between groups. Mann-Whitney test used to determine statistical significance between groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58adec63ac2802bd346cb81495e87314
https://doi.org/10.1158/0008-5472.22633290
https://doi.org/10.1158/0008-5472.22633290