Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.

Autor: Christopher B Forsyth, Kathleen M Shannon, Jeffrey H Kordower, Robin M Voigt, Maliha Shaikh, Jean A Jaglin, Jacob D Estes, Hemraj B Dodiya, Ali Keshavarzian

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28032 (2011)

Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the

Externí odkaz: https://doaj.org/article/8ca2c8dad6624dddb1a6f791ddea07aa

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

Autor: Ali Keshavarzian, Ece Mutlu, Hemraj B. Dodiya, Kathleen M. Shannon, Jean A. Jaglin, Delia M. Daian, Jeffrey H. Kordower

Publikováno v: Movement Disorders. 27:709-715

The diagnosis of Parkinson's disease rests on motor signs of advanced central dopamine deficiency. There is an urgent need for disease biomarkers. Clinicopathological evidence suggests that α-synuclein aggregation, the pathological signature of Park

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d55ec8a78ccba99a78982991a1e0b947
https://doi.org/10.1002/mds.23838

Which dyskinesia scale best detects treatment response?

Autor: Christopher G, Goetz, Glenn T, Stebbins, Kathryn A, Chung, Robert A, Hauser, Janis M, Miyasaki, Anthony P, Nicholas, Werner, Poewe, Klaus, Seppi, Olivier, Rascol, Mark A, Stacy, John G, Nutt, Caroline M, Tanner, Alison, Urkowitz, Jean A, Jaglin, Song, Ge

Publikováno v: Movement disorders : official journal of the Movement Disorder Society. 28(3)

Numerous scales assess dyskinesia in Parkinson's disease (PD), variably focusing on anatomical distribution, phenomenology, time, severity, and disability. No study has compared these scales and their relative ability to detect change related to an e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ab3be3c3d691969038e0d52ba5e5a38
https://pubmed.ncbi.nlm.nih.gov/23390076

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

Autor: Kathleen M, Shannon, Ali, Keshavarzian, Ece, Mutlu, Hemraj B, Dodiya, Delia, Daian, Jean A, Jaglin, Jeffrey H, Kordower

Publikováno v: Movement disorders : official journal of the Movement Disorder Society. 27(6)

The diagnosis of Parkinson's disease rests on motor signs of advanced central dopamine deficiency. There is an urgent need for disease biomarkers. Clinicopathological evidence suggests that α-synuclein aggregation, the pathological signature of Park

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9da4bed62e4d9ddf032078dbfe2e395
https://pubmed.ncbi.nlm.nih.gov/22649001

Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease

Autor: Micki McCollister, Julie Hevezi, Naomi Santoni, Tracey Tam, Rajesh Pahwa, Cynthia Alcorn-Costa, Barbara Fussell, Xiaoming Lu, Cheryl Armstrong, Peggy Gray, Patricia Dyches, Jovianna N. Wellinghoff, Shaunna Caouette, James B. Osborne, William C. Koller, Tilak Mendis, Shantelle Coe, Jacqueline Nash, Shirley Uy, Howard I. Hurtig, Susan Rolli, Tracy Stewart, Judy Richman, Susan Rolandelli, William G. Ondo, Cathi A. Thomas, Melodie Moterson, Maryan DeAngelis, Sheila Everett, Mary Mathews, Linda L. Mann, Eric Molho, Lorette J. Jenkins, Jessie Roth, Sandra K. Kostyk, Deborah L. Caputo, Ali H. Rajput, Jean Ayan, Un Jung Kang, Paul Atchison, Jo Belden, Julie So, Andew Feigin, Lisa Johnston, Lawrence I. Golb, Howard H. Hurtig, Larisa I. Skrypnik, Michael J. Aminoff, J. Carpenter, Patricia Seuffert, Carlos Singer, Amy Parsons, Kapil D. Sethi, Mark Forrest Gordon, Pam King, Mary Lloyd, Katherine B. Hawthorne, Linda Klassen, Shoba Narayan, Cathy R. Anderson, Patricia Kaminski, Karen Caplan, Robert A. Hauser, Dinorah Bateman, Erica Barnabei, Cheryl Fitzer-Attas, Kellie Gelles, Tamara Gales, Joanne Wojcieszek, Robert Hauser, Teri Radam, Karen Stavris, Carolyn C. Weeks, Marlene Gerow, Connie Kawai, Tracey Borst, Caroline M. Tanner, Charles H. Adler, Mickie Welsh, Nancy Pearson, Anita Lopez, Georgia Germain, Cathy W. Allen, Marianne Ewasnishin, Lisa Tagg, Brenda Ebbitt, Myrna Schear, Jean A. Jaglin, Roberta Winnick, Dawn Miller, Nancy Saton, Suzanne W. Schuman, Davoud Mohtat, Barbara Shannon, Vincent Calabrese, Mark F. Lew, Janis M. Miyasaki, William J. Weiner, Jody Lowery, Christine Hunter, Diane Brown, Keely Haas, Paul J. Tuite, Peter A. LeWitt, Mirann DiMinno, Cheryl Cooper, Peter Novak, Robert G. Feldman, Joanne Hamann, Sharon Evans, W.R. Wayne Martin, Mark Stacy, Debra Berry, Sharon Wortzel, John M. Bertoni, Kenneth Marek, Kelli Williamson, Lisa Gauger, Cheryl Newcomb, Carolyn Peterson, K. Ligon, Stephanie Newman, Vanessa Patterson, Peggy Roberge, Arif Dalvi, Laura Sutherland, Frederick J. Marshall, Scott Cradr, Karen Betcher, Carolyn Deloa, Jean P. Hubble, Kathleen M. Shannon, Sharyn Parness, Neila Mendis, Germanine McInnes, Adrienne Baranauskas, Irenita Gardiner

Publikováno v: Movement disorders : official journal of the Movement Disorder Society. 24(4)

The purpose of this study to compare the long-term clinical outcome of early versus delayed rasagiline treatment in early Parkinson's disease (PD). Subjects (N = 404) were randomly assigned to initial treatment with rasagiline (early-start group) or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c1b25f770cd378b533ccf4794159c9
https://pubmed.ncbi.nlm.nih.gov/19086083