Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jean A. Hartsuck"'
Publikováno v:
Protein Science. 19:2175-2185
Memapsin 2 (BACE1, β-secretase), a membrane aspartic protease, functions in the cleavage of brain β-amyloid precursor protein (APP) leading to the production of β-amyloid. Because the excess level of β-amyloid in the brain is a leading factor in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18b667afab546a9a4661a80ed1ac7e2
https://doi.org/10.1002/pro.502
https://doi.org/10.1002/pro.502
Publikováno v:
Protein Science. 9:1898-1904
Saquinavir is a widely used HIV-1 protease inhibitor drug for AIDS therapy. Its effectiveness, however, has been hindered by the emergence of resistant mutations, a common problem for inhibitor drugs that target HIV-1 viral enzymes. Three HIV-1 prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8f4ace59d2a27ca45dcb0a68244b8d
https://doi.org/10.1110/ps.9.10.1898
https://doi.org/10.1110/ps.9.10.1898
Publikováno v:
Protein Science. 7:300-305
The mutation Ala28 to serine in human immunodeficiency virus, type 1, (HIV-1) protease introduces putative hydrogen bonds to each active-site carboxyl group. These hydrogen bonds are ubiquitous in pepsin-like eukaryotic aspartic proteases. In order t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40c8c5dcdad033d01e2ca13b1fe59f86
https://doi.org/10.1002/pro.5560070209
https://doi.org/10.1002/pro.5560070209
Publikováno v:
FEBS Letters. 420:11-16
The crystal structure of human immunodeficiency virus type 1 (HIV-1) protease mutant G48H with peptidic inhibitor U-89360E is described. Comparison with wild-type protease-inhibitor complex shows that mutation of flap residue 48 to histidine allows s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::841760633178411d72dd275b8a5867c9
https://doi.org/10.1016/s0014-5793(97)01477-4
https://doi.org/10.1016/s0014-5793(97)01477-4
Publikováno v:
Biochemistry. 35:10627-10633
Crystal structures of the protease of human immunodeficiency virus type 1 (HIV-1) and two mutant proteases, V82D and V82N, have been determined. In all three cases the enzyme forms a complex with the peptidic inhibitor U-89360E. All structures have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681cd244ac24c93d3261d6e669ae3dcd
https://doi.org/10.1021/bi960481s
https://doi.org/10.1021/bi960481s
Autor:
Jean A. Hartsuck, Jordan Tang
Publikováno v:
FEBS Letters. 367:112-116
A kinetic model is presented for the comparison of potential proteolytic processing activities of wild-type and mutant human immunodeficiency virus proteases in the presence and absence of protease inhibitors. The protease processing of gag substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aac70837a1fffbc067deab1107bf307
https://doi.org/10.1016/0014-5793(95)00547-m
https://doi.org/10.1016/0014-5793(95)00547-m
Autor:
Chi-Sun Wang, Jean A. Hartsuck
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1166:1-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04636f7fcd6daef0e0f13aabfb8f6d46
https://doi.org/10.1016/0005-2760(93)90277-g
https://doi.org/10.1016/0005-2760(93)90277-g
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. 52:127-135
The protease of human immunodeficiency virus (HIV) has been extensively studied. The structure and function relationships of this protease and its role in HIV life cycle is well known. We have use recombinant HIV protease and mutagenesis technology t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516bf93e912e5f4c227a79f0ab7ff3cc
https://doi.org/10.1080/00365519209104661
https://doi.org/10.1080/00365519209104661
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1043:143-148
The sequential lipolysis of trioleoylglycerol and the triacylglycerols of very-low-density lipoprotein by bovine milk lipoprotein lipase can be described by the consecutive reactions: Triacylglycerol → k′ 1 diacylglycerol → k′ 2 monoacylglyce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e50d952276fece756f9b65ac8baf371
https://doi.org/10.1016/0005-2760(90)90287-8
https://doi.org/10.1016/0005-2760(90)90287-8
Publikováno v:
Aspartic Proteinases ISBN: 9781461374527
Human immunodeficiency virus (HIV) protease is responsible for the processing of gag and gag-pol polyprotein precursors to produce structural proteins and enzymes for the mature virus. Hence, it is essential for the maturation and infectivity of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecba5d9dccd60f12258b863d101aabed
https://doi.org/10.1007/978-1-4615-5373-1_8
https://doi.org/10.1007/978-1-4615-5373-1_8
