Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jean M. Veith"'
Autor:
Ilaria Zanardi, Jon Mallen-St. Clair, Iwao Ojima, Susan Band Horwitz, Shujun Xia, Xianrui Zhao, Dafna Bar-Sagi, David Gallager, Jin Chen, Tao Wang, Xudong Geng, Michael L. Miller, Ralph J. Bernacki, Larisa V. Kuznetsova, Songnian Lin, Jean M. Veith, Jennifer L. Guerriero, Chuanxing Qu, Liang Sun, Christopher P. Borella, Paula Pera
Publikováno v:
Journal of Medicinal Chemistry. 51:3203-3221
Novel second-generation taxoids with systematic modifications at the C2, C10, and C3'N positions were synthesized and their structure-activity relationships studied. A number of these taxoids exhibited exceptionally high potency against multidrug-res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d811bbf1dba302b8e6afa428c01a96
https://doi.org/10.1021/jm800086e
https://doi.org/10.1021/jm800086e
Autor:
Kristin Kee, Peter Kanter, Jean M. Veith, Fernando Cabral, William R. Greco, Amarnath Sharma, Iwao Ojima, Michael R. Vredenburg, Paula Pera, Ralph J. Bernacki
Publikováno v:
JNCI Journal of the National Cancer Institute. 93:1234-1245
Background: The taxane paclitaxel (Taxol) is often of limited efficacy in chemotherapeutic regimens because some cancer cells express high levels of the efflux pump, P-glycoprotein (Pgp), which removes the drug from the cells. The orally active pacli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11792237481a647879d38c23e8e1800d
https://doi.org/10.1093/jnci/93.16.1234
https://doi.org/10.1093/jnci/93.16.1234
Publikováno v:
Journal of Medicinal Chemistry. 40:279-285
Several new nonaromatic taxoids are synthesized by means of the beta-lactam synthon method. These include taxoids modified with 3-methylbut-2-enoate, 3-methylbutanoate, and cyclohexanecarboxylate groups in place of the benzoate at the C-2 position. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1d79746bd82d7a7e48fed57ed229fe
https://doi.org/10.1021/jm9606711
https://doi.org/10.1021/jm9606711
Autor:
Paula Pera, John C. Slater, Jean M. Veith, Jean-Pierre Bégué, Iwao Ojima, Ahmed Abouabdellah, Ralph J. Bernacki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:133-138
Second generation taxoids possessing a trifluoromethyl moiety in place of the 3′-phenyl group are synthesized by means of the β-Lactam Synthon Method. The in vitro cytotoxicities of these new taxoids are evaluated against several different human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b58c22b7fc3a9796f73220aa98fdbad6
https://doi.org/10.1016/s0960-894x(96)00595-1
https://doi.org/10.1016/s0960-894x(96)00595-1
Autor:
John C. Slater, Ralph J. Bernacki, Scott D. Kuduk, Pierre-Yves Bounaud, Patricia Vrignaud, Evelyne Michaud, Jean M. Veith, Paula Pera, Iwao Ojima, Marie-Christine Bissery
Publikováno v:
Journal of Medicinal Chemistry. 39:3889-3896
A series of new 3'-(2-methyl-1-propenyl) and 3'-(2-methylpropyl) taxoids with modifications at C-10 was synthesized by means of the beta-lactam synthon method using 10-modified 7-(triethylsilyl)-10-deacetylbaccatin III derivatives. The new taxoids th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2899b89db3144ecdee08a29ac0b79e8c
https://doi.org/10.1021/jm9604080
https://doi.org/10.1021/jm9604080
Autor:
Chung-Ming Sun, Ralph J. Bernacki, John C. Slater, Scott D. Kuduk, Iwao Ojima, Olivier Duclos, François Lavelle, Jean M. Veith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2631-2634
3-Alkyl- and 3′-alkenyl-3′-dephenyldocetaxels are synthesized from 10-deacetylbaccatin III based on the β-lactam synthon method in good yields. The cytotoxicity of the new taxoids are evaluated against different human tumor cell lines and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f161e3c6945d4b451bdb6440dd6450f0
https://doi.org/10.1016/s0960-894x(01)80298-5
https://doi.org/10.1016/s0960-894x(01)80298-5
Autor:
Ahmed Abouabdellah, Jean M. Veith, Ralph J. Bernacki, Paula Pera, John C. Slater, Jean-Pierre Bégué, Iwao Ojima
Publikováno v:
ChemInform. 28
Second generation taxoids possessing a trifluoromethyl moiety in place of the 3′-phenyl group are synthesized by means of the β-Lactam Synthon Method. The in vitro cytotoxicities of these new taxoids are evaluated against several different human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34be7687d04beb30475a96cc090e55de
https://doi.org/10.1002/chin.199720155
https://doi.org/10.1002/chin.199720155
Autor:
Karoly Toth, Ralph J. Bernacki, Beom Soo Shin, Joseph P. Balthasar, Dhaval K. Shah, Jean M. Veith
The efficacy of intraperitoneal chemotherapy for ovarian cancers is limited by poor penetration of drug into peritoneal tumors. Based on pharmacokinetic theory that suggests that penetration depth is primarily determined by the rate of drug removal v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2536f71aa8ee95a58364c4dbbd8972c
https://europepmc.org/articles/PMC2672874/
https://europepmc.org/articles/PMC2672874/
Autor:
Jean M. Veith, Raphaël Geney, Ralph J. Bernacki, Shujun Xia, Carlos Simmerling, Joseph W. Lauher, Iwao Ojima, Xudong Geng, Susan Band Horwitz, Zhong Li, Paula Pera, Yuan Li, Liang Sun
Novel macrocyclic paclitaxel congeners were designed to mimic the bioactive conformation of paclitaxel. Computational analysis of the "REDOR-Taxol" structure revealed that this structure could be rigidified by connecting the C14 position of the bacca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea52346f1faf0ac9b9c8436f7a6ad674
https://europepmc.org/articles/PMC2736308/
https://europepmc.org/articles/PMC2736308/
Autor:
Paula Pera, Xinyuan Wu, Antonella Pepe, Jin Chen, Jean M. Veith, Ralph J. Bernacki, Iwao Ojima, Larissa V. Kuznetsova, Liang Sun
Publikováno v:
ChemInform. 37
Polyunsaturated fatty acids such as docosahexaenoic acid (DHA), linolenic acid, and linoleic acid were linked to the C-2' position of the second-generation taxoids that could overcome MDR caused by overexpressed ABC transporters. The new conjugates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b84cc6fc961761924e689f6570b18bac
https://doi.org/10.1002/chin.200620188
https://doi.org/10.1002/chin.200620188