Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Jean‐Sébastien Rougier"'
Autor:
Oksana Iamshanova, Anne-Flore Hämmerli, Elise Ramaye, Arbresh Seljmani, Daniela Ross-Kaschitza, Noëlia Schärz, Maria Essers, Sabrina Guichard, Jean-Sébastien Rougier, Hugues Abriel
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0298820 (2024)
Background14-3-3 proteins are ubiquitous proteins that play a role in cardiac physiology (e.g., metabolism, development, and cell cycle). Furthermore, 14-3-3 proteins were proposed to regulate the electrical function of the heart by interacting with
Externí odkaz:
https://doaj.org/article/439cc23a2bf14e7ea79dc9cac3417ec1
Autor:
Prakash Arullampalam, Maria C. Essers, Mey Boukenna, Sabrina Guichard, Jean‐Sébastien Rougier, Hugues Abriel
Publikováno v:
Physiological Reports, Vol 11, Iss 16, Pp n/a-n/a (2023)
Abstract TRPM4 is a calcium‐activated, voltage‐modulated, nonselective ion channel widely expressed in various cells and tissues. TRPM4 regulates the influx of sodium ions, thus playing a role in regulating the membrane potential. In the heart, T
Externí odkaz:
https://doaj.org/article/1c6e5421255e44d1a674594638ca807f
Autor:
Barbara Preti, Jean-Sébastien Rougier, Irida Papapostolou, Florian Bochen, Christian E. Gerber, Hugues Abriel, Martin Lochner, Christine Peinelt
Publikováno v:
CHIMIA, Vol 76, Iss 12 (2022)
The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecu
Externí odkaz:
https://doaj.org/article/344d922443754d068dbe864dca6661ba
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/97d92d4cc3d1498aac1cebaa106ccc48
Autor:
Prakash Arullampalam, Barbara Preti, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sébastien Rougier, Hugues Abriel
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: The Transient Receptor Potential Melastatin member 4 (TRPM4) gene encodes a calcium-activated non-selective cation channel expressed in several tissues. Mutations in TRPM4 have been reported in patients with different types of cardiac con
Externí odkaz:
https://doaj.org/article/21cf137dbdef48c6a253499e00e162a1
Autor:
Jean-Sébastien Rougier, Maria C. Essers, Ludovic Gillet, Sabrina Guichard, Stephan Sonntag, Doron Shmerling, Hugues Abriel
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Background: In cardiac ventricular muscle cells, the presence of voltage-gated sodium channels Nav1.5 at the lateral membrane depends in part on the interaction between the dystrophin–syntrophin complex and the Nav1.5 C-terminal PDZ-domain-binding
Externí odkaz:
https://doaj.org/article/40f1bfc6769543c08b5d2a4c61a582dc
Autor:
Ninda Syam, Stéphanie Chatel, Lijo Cherian Ozhathil, Valentin Sottas, Jean‐Sébastien Rougier, Alban Baruteau, Estelle Baron, Mohamed‐Yassine Amarouch, Xavier Daumy, Vincent Probst, Jean‐Jacques Schott, Hugues Abriel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 5 (2016)
BackgroundTransient receptor potential melastatin member 4 (TRPM4) is a nonselective cation channel. TRPM4 mutations have been linked to cardiac conduction disease and Brugada syndrome. The mechanisms underlying TRPM4‐dependent conduction slowing a
Externí odkaz:
https://doaj.org/article/86d158a96cb74f1c8ec84708488e21c6
Publikováno v:
F1000Research, Vol 2 (2013)
Background: The pore-forming subunit of the cardiac sodium channel, Nav1.5, has been previously found to be mutated in genetically determined arrhythmias. Nav1.5 associates with many proteins that regulate its function and cellular localisation. In o
Externí odkaz:
https://doaj.org/article/e5c86efb9c7546bd9d6ff46648ed5f53
Autor:
Anne-Laure Leoni, Bruno Gavillet, Jean-Sébastien Rougier, Céline Marionneau, Vincent Probst, Solena Le Scouarnec, Jean-Jacques Schott, Sophie Demolombe, Patrick Bruneval, Christopher L H Huang, William H Colledge, Andrew A Grace, Hervé Le Marec, Arthur A Wilde, Peter J Mohler, Denis Escande, Hugues Abriel, Flavien Charpentier
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9298 (2010)
Loss-of-function mutations in SCN5A, the gene encoding Na(v)1.5 Na+ channel, are associated with inherited cardiac conduction defects and Brugada syndrome, which both exhibit variable phenotypic penetrance of conduction defects. We investigated the m
Externí odkaz:
https://doaj.org/article/cdbbe44739414c65b378bc6914b4ef64
Autor:
Mey Boukenna, Prakash Arullampalam, Choshiman Taib, Sabrina Guichard, Jean-Sébastien Rougier, Michael H. Gollob, Hugues Abriel
BackgroundTRPM4 is a Ca2+-activated ion channel permeable to monovalent cations. Its expression in the heart has been confirmed, with most data supporting its presence in the conductive cardiac tissue. Numerous investigations have linkedTRPM4mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a76c6d80560a250e55adeb639106845
https://doi.org/10.1101/2023.03.29.534743
https://doi.org/10.1101/2023.03.29.534743
