T cell immuno-phenotyping : a source of predictive biomarkers for autoimmune hepatitis relapse

Autor: Astrid Imbert, Pierre-Jean Gavlovsky, Jean-Paul Judor, Edouard Bardou-Jacquet, Laure Elkrief, Adrien Lannes, Christine Silvain, Mathieu Schnee, Florence Tanne, Caroline Chevalier, Fabienne Vavasseur, Marion Khaldi, Sophie Brouard, Jean-François Mosnier, Jérôme Gournay, Sophie Conchon, Amédée Renand

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Relapse after immunosuppression (IS) treatment withdrawal is frequent in patients with Autoimmune Hepatitis (AIH), and non-invasive biomarkers predictive of this risk are lacking. We assessed the frequency of circulating T cell subsets as po

Externí odkaz: https://doaj.org/article/f249c91e0f4045b49ea2ccb0dae5c652

Corrigendum: Broad Impairment of Natural Killer Cells From Operationally Tolerant Kidney Transplanted Patients

Autor: Emilie Dugast, Gaëlle David, Romain Oger, Richard Danger, Jean-Paul Judor, Katia Gagne, Mélanie Chesneau, Nicolas Degauque, Jean-Paul Soulillou, Pascale Paul, Christophe Picard, Pierrick Guerif, Sophie Conchon, Magali Giral, Nadine Gervois, Christelle Retière, Sophie Brouard

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Externí odkaz: https://doaj.org/article/558d0cdccd1644dd9b63ceb1d383828a

Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs.

Autor: Olivier Reynard, Frédéric Jacquot, Gwénaëlle Evanno, Hoa Le Mai, Apolline Salama, Bernard Martinet, Odile Duvaux, Jean-Marie Bach, Sophie Conchon, Jean-Paul Judor, Andrea Perota, Irina Lagutina, Roberto Duchi, Giovanna Lazzari, Ludmilla Le Berre, Hélène Perreault, Elsa Lheriteau, Hervé Raoul, Viktor Volchkov, Cesare Galli, Jean-Paul Soulillou

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0156775 (2016)

Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their usage in new applications such as Ebola hemorrhagic fever. IgG glycans display powerful xe

Externí odkaz: https://doaj.org/article/3c48cfab991749ad839dcf1c00ecbd4f

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

Autor: Sophie Conchon, Alexandra Garcia, Béatrice Clémenceau, Fabienne Vavasseur, Sarah Habes, Hélène Aublé, Sophie Brouard, Laurine Gil, Florence Tanné, Anaïs Cardon, David-Axel Laplaud, Caroline Chevalier, Jean-Paul Judor, Jean-François Mosnier, Pierre Milpied, Chuang Dong, Jérôme Gournay, Inaki Cervera-Marzal, Erwan Kervagoret, Amédée Renand

Publikováno v: Journal of Hepatology
Journal of Hepatology, Elsevier, 2020, ⟨10.1016/j.jhep.2020.05.053⟩
Journal of Hepatology, 2020, ⟨10.1016/j.jhep.2020.05.053⟩

International audience; Background & aims: In most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-soluble liver antigen (SLA) autoantibodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b342f7438e6a10f6a78d17c13e796e89
https://hal.archives-ouvertes.fr/hal-02982210

Immune Alterations in Patients With Type 1 Autoimmune Hepatitis Persist Upon Standard Immunosuppressive Treatment

Autor: Sophie Conchon, Jean-François Mosnier, Isabelle Archambeaud, Jérôme Gournay, Sylvie Métairie, Philippe Hulin, Sarah Habes, Hélène Aublé, Amédée Renand, Steven Nedellec, Sophie Brouard, Nicolas Vince, Jean-Paul Judor

Publikováno v: Hepatology Communications, Vol 2, Iss 8, Pp 972-985 (2018)
HAL
International Hepatology Communications
International Hepatology Communications, Elsevier, 2018, 2 (8), pp.968-981
International Hepatology Communications, 2018, 2 (8), pp.968-981
Hepatology Communications

Autoimmune hepatitis (AIH) is a rare disease characterized by an immune attack of the liver. This study consists of a comprehensive analysis of immune alterations related to AIH at diagnosis, and during remission phase under treatment. A total of 37

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3081dfd5125f60bdc9779ad0a9fcf2
https://doi.org/10.1002/hep4.1202