Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Jean‐Noël Octave"'
Autor:
Anna Kreis, Farah Issa, Xavier Yerna, Caren Jabbour, Olivier Schakman, Marie de Clippele, Nicolas Tajeddine, Nathalie Pierrot, Jean-Noël Octave, Roberta Gualdani, Philippe Gailly
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The postsynaptic inhibition through GABAA receptors (GABAAR) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of chloride into p
Externí odkaz:
https://doaj.org/article/20af515e71b6444192b6522210975573
Autor:
Anna Kreis, Jana Desloovere, Nuria Suelves, Nathalie Pierrot, Xavier Yerna, Farah Issa, Olivier Schakman, Roberta Gualdani, Marie de Clippele, Nicolas Tajeddine, Pascal Kienlen-Campard, Robrecht Raedt, Jean-Noël Octave, Philippe Gailly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The function of the amyloid precursor protein (APP) is not fully understood, but its cleavage product amyloid beta (Aβ) together with neurofibrillary tangles constitute the hallmarks of Alzheimer’s disease (AD). Yet, imbalance of excitato
Externí odkaz:
https://doaj.org/article/8573bf1d0f514383a0caa67d43212752
Autor:
Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachter
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Abstract Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered key contributors to AD pathogenes
Externí odkaz:
https://doaj.org/article/852fe2a6f7d24a1d8306a8d889edd584
Autor:
Francisco Sáez-Orellana, Thomas Leroy, Floriane Ribeiro, Anna Kreis, Karelle Leroy, Fanny Lalloyer, Eric Baugé, Bart Staels, Charles Duyckaerts, Jean-Pierre Brion, Philippe Gailly, Jean-Noël Octave, Nathalie Pierrot
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Among genetic susceptibility loci associated with late-onset Alzheimer disease (LOAD), genetic polymorphisms identified in genes encoding lipid carriers led to the hypothesis that a disruption of lipid metabolism could promote disease progression. We
Externí odkaz:
https://doaj.org/article/e8a9b89247db4df9868a05e462a785d5
Autor:
Anna Doshina, Florian Gourgue, Michiho Onizuka, Remi Opsomer, Peng Wang, Kunie Ando, Bernadette Tasiaux, Ilse Dewachter, Pascal Kienlen-Campard, Jean-Pierre Brion, Philippe Gailly, Jean-Noël Octave, Nathalie Pierrot
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride con
Externí odkaz:
https://doaj.org/article/17df00cf26f446d68bc775b9993f6c1a
Autor:
Chaur-Jong Hu, Jean-Noël Octave
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/3bd73b6e6ac74446a6e860d1987ad5f3
Publikováno v:
Cells, Vol 9, Iss 5, p 1215 (2020)
Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Mutations in genes encoding proteins involved in amyloid-β peptide (Aβ) production are responsible for inherited AD cases. The amyloid cascade hypothesis was proposed to ex
Externí odkaz:
https://doaj.org/article/848cdead55164befa8989ecc5d4609ed
Autor:
Caroline Evrard, Pascal Kienlen-Campard, Mathilde Coevoet, Rémi Opsomer, Bernadette Tasiaux, Patricia Melnyk, Jean-Noël Octave, Luc Buée, Nicolas Sergeant, Valérie Vingtdeux
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Aβ peptides, the major components of Alzheimer’s disease (AD) amyloid deposits, are released following sequential cleavages by secretases of its precursor named the amyloid precursor protein (APP). In addition to secretases, degradation pathways,
Externí odkaz:
https://doaj.org/article/2633ffaf0c1f45a6a5fa8fc69f8a5625
Autor:
Serena Stanga, Liliana Brambilla, Bernadette Tasiaux, Anh H. Dang, Adrian Ivanoiu, Jean-Noël Octave, Daniela Rossi, Vincent van Pesch, Pascal Kienlen-Campard
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
The current inability of clinical criteria to accurately identify the “at-risk group” for Amyotrophic Lateral Sclerosis (ALS) development as well as its unknown etiology are fueling the interest in biomarkers aimed at completing clinical approach
Externí odkaz:
https://doaj.org/article/265cd9fd89fa4895a200885e095db5a2
Autor:
Marie Decock, Laetitia El Haylani, Serena Stanga, Ilse Dewachter, Jean-Noël Octave, Steven O. Smith, Stefan N. Constantinescu, Pascal Kienlen-Campard
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 763-773 (2015)
Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive loss of cognitive functions, leading to dementia. Two types of lesions are found in AD brains: neurofibrillary tangles and senile plaques. The latter are composed mainly
Externí odkaz:
https://doaj.org/article/17de4ce661c4404e8961ebca1d556998