Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Jean‐Marie Delaisse"'
Autor:
Sarah Santiloni Cury, Hellen Kuasne, Jeferson dos Santos Souza, Juan Jose Moyano Muñoz, Jeyson Pereira da Silva, Ademar Lopes, Cristovam Scapulatempo-Neto, Eliney Ferreira Faria, Jean-Marie Delaissé, Fabio Albuquerque Marchi, Silvia Regina Rogatto
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Extracellular matrix (ECM) remodeling and inflammation have been reported in penile carcinomas (PeCa). However, the cell types and cellular crosstalk involved in PeCa are unexplored. We aimed to characterize the complexity of cells and pathways invol
Externí odkaz:
https://doaj.org/article/a2f43b984e634f36a7f7b6c88d6fea3b
Autor:
Bilal M. El-Masri, Christina M. Andreasen, Kaja S. Laursen, Viktoria B. Kofod, Xenia G. Dahl, Malene H. Nielsen, Jesper S. Thomsen, Annemarie Brüel, Mads S. Sørensen, Lars J. Hansen, Albert S. Kim, Victoria E. Taylor, Caitlyn Massarotti, Michelle M. McDonald, Xiaomeng You, Julia F. Charles, Jean-Marie Delaisse, Thomas L. Andersen
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-21 (2024)
Abstract Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases bone mass, and reduces fracture risk. Denosumab discontinuation causes an extensive wave of rebound resorption, but the cellular mechanisms remain poorly
Externí odkaz:
https://doaj.org/article/debb0e5b2c6f4fcd819cdbe0ec3b3e1c
Autor:
Preety Panwar, Jacob Bastholm Olesen, Galia Blum, Jean-Marie Delaisse, Kent Søe, Dieter Brömme
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Cathepsin K (CatK), an essential collagenase in osteoclasts (OCs), is a potential therapeutic target for the treatment of osteoporosis. Using live-cell imaging, we monitored the bone resorptive behaviour of OCs during dose-dependent inhibiti
Externí odkaz:
https://doaj.org/article/92cb3c72ac144f1391fde56b99a57085
Autor:
Pernille vanDijk Christiansen, Tanja Sikjær, Christina Møller Andreasen, Jesper Skovhus Thomsen, Annemarie Brüel, Ellen Margrethe Hauge, Jean‐Marie Delaisse, Lars Rejnmark, Thomas Levin Andersen
Publikováno v:
JBMR Plus, Vol 7, Iss 12, Pp n/a-n/a (2023)
ABSTRACT In hypoparathyroidism, lack of parathyroid hormone (PTH) leads to low calcium levels and decreased bone remodeling. Treatment with recombinant human PTH (rhPTH) may normalize bone turnover. This study aimed to investigate whether rhPTH(1–8
Externí odkaz:
https://doaj.org/article/577b8c5a0d184c0aaba5bc2ca3f82332
Autor:
Qihua Tan, Anaïs Marie Julie Møller, Chuan Qiu, Jonna Skov Madsen, Hui Shen, Troels Bechmann, Jean-Marie Delaisse, Bjarne Winther Kristensen, Hong-Wen Deng, David Karasik, Kent Søe
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Clinical trials have shown zoledronic acid as a potent bisphosphonate in preventing bone loss, but with varying potency between patients. Human osteoclasts ex vivo reportedly displayed a variable sensitivity to zoledronic acid > 2
Externí odkaz:
https://doaj.org/article/9718cb5c044c48b18465cf4ae6ccc452
Autor:
Xenia G. Borggaard, Malene H. Nielsen, Jean-Marie Delaisse, Christina M. Andreasen, Thomas L. Andersen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The strictly regulated bone remodeling process ensures that osteoblastic bone formation is coupled to osteoclastic bone resorption. This coupling is regulated by a panel of coupling factors, including clastokines promoting the recruitment, expansion,
Externí odkaz:
https://doaj.org/article/cbb3ebbbab6049a097135149ac2d3c11
Autor:
Jean-Marie Delaisse, Kent Søe, Thomas Levin Andersen, Aleksandra Maria Rojek, Niels Marcussen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The current models of osteoclastic bone resorption focus on immobile osteoclasts sitting on the bone surface and drilling a pit into the bone matrix. It recently appeared that many osteoclasts also enlarge their pit by moving across the bone surface
Externí odkaz:
https://doaj.org/article/2b2e8228219f4f88b11df243dfc6830c
Autor:
Helene Bjoerg Kristensen, Thomas Levin Andersen, Andrea Patriarca, Klaus Kallenbach, Birgit MacDonald, Tanja Sikjaer, Charlotte Ejersted, Jean-Marie Delaisse
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250081 (2021)
Dormancy of hematopoietic stem cells and formation of progenitors are directed by signals that come from the bone marrow microenvironment. Considerable knowledge has been gained on the murine hematopoietic stem cell microenvironment, while less so on
Externí odkaz:
https://doaj.org/article/e43f7f7c28cc40aaa68cb4af134fd865
Autor:
Anaïs M J Møller, Jean‐Marie Delaisse, Jacob B Olesen, Troels Bechmann, Jonna S Madsen, Kent Søe
Publikováno v:
JBMR Plus, Vol 4, Iss 11, Pp n/a-n/a (2020)
ABSTRACT Zoledronic acid is a bisphosphonate commonly used to treat bone diseases such as osteoporosis and cancer‐induced bone disease. Patients exhibit a variable sensitivity to zoledronic acid; the underlying explanation for this remains unclear.
Externí odkaz:
https://doaj.org/article/4afaae1161b84d5cb464b460f4ea11bd
Autor:
Abbas Jafari, Diyako Qanie, Thomas L. Andersen, Yuxi Zhang, Li Chen, Benno Postert, Stuart Parsons, Nicholas Ditzel, Sundeep Khosla, Harald Thidemann Johansen, Per Kjærsgaard-Andersen, Jean-Marie Delaisse, Basem M. Abdallah, Daniel Hesselson, Rigmor Solberg, Moustapha Kassem
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 373-386 (2017)
Secreted factors are a key component of stem cell niche and their dysregulation compromises stem cell function. Legumain is a secreted cysteine protease involved in diverse biological processes. Here, we demonstrate that legumain regulates lineage co
Externí odkaz:
https://doaj.org/article/782585447d384deda27d1d3eeee9abb1