Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Jean‐Marc Egly"'
Autor:
Jérémy Sandoz, Max Cigrang, Amélie Zachayus, Philippe Catez, Lise-Marie Donnio, Clèmence Elly, Jadwiga Nieminuszczy, Pietro Berico, Cathy Braun, Sergey Alekseev, Jean-Marc Egly, Wojciech Niedzwiedz, Giuseppina Giglia-Mari, Emmanuel Compe, Frédéric Coin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here the authors show that the exonuclease EXD2 is involved in the recovery of class II gene transcription after UV irradiation. EXD2 travels from the mitochondria to the nucleus to interact with RNA Pol II and degrade new synthetized mRNA to allow t
Externí odkaz:
https://doaj.org/article/a0d3f932123e4cc6bc846c308c77597d
Autor:
Chia-Yu Guh, Hong-Jhih Shen, Liv WeiChien Chen, Pei-Chen Chiu, I-Hsin Liao, Chen-Chia Lo, Yunfei Chen, Yu-Hung Hsieh, Ting-Chia Chang, Chien-Ping Yen, Yi-Yun Chen, Tom Wei-Wu Chen, Liuh-Yow Chen, Ching-Shyi Wu, Jean-Marc Egly, Hsueh-Ping Catherine Chu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend
Externí odkaz:
https://doaj.org/article/a1fb0e9f73254a64ac93c3ea84dcbcc8
Autor:
Stefan Peissert, Florian Sauer, Daniel B. Grabarczyk, Cathy Braun, Gudrun Sander, Arnaud Poterszman, Jean-Marc Egly, Jochen Kuper, Caroline Kisker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
XPD is part of the TFIIH complex which plays major roles in transcription initiation and nucleotide excision repair (NER). Here the authors present a high-resolution crystal structure of the XPD-MAT1 interface and dissect the role of this interface i
Externí odkaz:
https://doaj.org/article/52a2dac0f1f34c4a966c28ea3af6e495
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The general transcription factors TFIIE and TFIIH assemble at the transcription start site with RNA Polymerase II. Here the authors provide evidence that the TFIIEα and TFIIEβ subunits anchor the TFIIH kinase module within the preinitiation complex
Externí odkaz:
https://doaj.org/article/121d77056e3d4d43a399accbfabcc5df
Autor:
Jérémy Sandoz, Zita Nagy, Philippe Catez, Gizem Caliskan, Sylvain Geny, Jean-Baptiste Renaud, Jean-Paul Concordet, Arnaud Poterszman, Laszlo Tora, Jean-Marc Egly, Nicolas Le May, Frédéric Coin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Chromatin structure plays a significant role in the regulation of gene expression. Here the authors show that TFIIH interacts with the histone acetyl transferase KAT2A and recruits the ATAC/hSAGA complexes to chromatin; and that loss of xeroderma pig
Externí odkaz:
https://doaj.org/article/c3b2c0ec8f5b4543bcc98340f8ba7994
Autor:
Maxi Hofrichter, Laura Nimtz, Julia Tigges, Yaschar Kabiri, Friederike Schröter, Brigitte Royer-Pokora, Barbara Hildebrandt, Martin Schmuck, Alexey Epanchintsev, Stephan Theiss, James Adjaye, Jean-Marc Egly, Jean Krutmann, Ellen Fritsche
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 72-82 (2017)
Developmental neurotoxicity (DNT) testing performed in rats is resource-intensive (costs, time, animals) and bears the issue of species extrapolation. Thus, reliable alternative human-based approaches are needed for predicting neurodevelopmental toxi
Externí odkaz:
https://doaj.org/article/98ecb7605fe2410a96b658b6b4f7c456
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004732 (2014)
The expression of protein-coding genes requires the selective role of many transcription factors, whose coordinated actions remain poorly understood. To further grasp the molecular mechanisms that govern transcription, we focused our attention on the
Externí odkaz:
https://doaj.org/article/d0105cf9646142f095af1cd13188f5b2
Autor:
Jochen Kuper, Cathy Braun, Agnes Elias, Gudrun Michels, Florian Sauer, Dominik R Schmitt, Arnaud Poterszman, Jean-Marc Egly, Caroline Kisker
Publikováno v:
PLoS Biology, Vol 12, Iss 9, p e1001954 (2014)
The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER). Mutations in human XPD are associated with several inherited diseases such as xeroderma pigmentosum, Cockayne syndrome,
Externí odkaz:
https://doaj.org/article/88cc70ed5c364099a3152604a61d9dd6
Autor:
Gaétan Bour, Fernand Martel, Laurent Goffin, Bernard Bayle, Jacques Gangloff, Marc Aprahamian, Jacques Marescaux, Jean-Marc Egly
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106675 (2014)
Hepatocellular carcinoma (HCC) is one of the most common cancer related deaths worldwide. One of the main challenges in cancer treatment is drug delivery to target cancer cells specifically. Preclinical evaluation of intratumoral drugs in orthotopic
Externí odkaz:
https://doaj.org/article/d6a7cad97c56439da39067b30ff15684
Autor:
Valentyn Oksenych, Alexander Zhovmer, Salim Ziani, Pierre-Olivier Mari, Jitka Eberova, Tiziana Nardo, Miria Stefanini, Giuseppina Giglia-Mari, Jean-Marc Egly, Frédéric Coin
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003611 (2013)
UV-induced DNA damage causes repression of RNA synthesis. Following the removal of DNA lesions, transcription recovery operates through a process that is not understood yet. Here we show that knocking-out of the histone methyltransferase DOT1L in mou
Externí odkaz:
https://doaj.org/article/b84d0c33fa5f4634b36e076cc9a637ef