Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool

Autor: Roland Lawson, Sophie Leymarie, Claire Nikitopoulos, Antoine Humeau, Hichem Bouchenaki, Jean‐Luc Duroux, Laurent Fourcade, Sandrine Karam, Nicolas Picard, Claire Demiot

Publikováno v: Pharmacology Research & Perspectives, Vol 10, Iss 1, Pp n/a-n/a (2022)

Abstract Regarding animal experiments in pharmacology teaching, ethical considerations led us to examine an alternative approach to the use of living animals. This study aimed to assess whether digital tools could replace live animal experiments in t

Externí odkaz: https://doaj.org/article/2fa992f037c740ecad0240d40bf3a596

Chemical composition and biological potential of Thymus Willdenowii Boiss. & Reut. essential oil

Autor: Jean-Luc Duroux, Claude-Alain Calliste, Alain Simon, Zahia Kabouche, Rim Charfeddine, Ahmed Kabouche, Assia Zeghib, Mahjoub Aouni

Publikováno v: Natural Product Research. 35:845-848

The fresh aerial parts of Thymus willdenowii Boiss. & Reut. (syn. Thymus hirtus Willd.) were hydrodistilled in a Clevenger type apparatus and analyzed by GC and GC-MS. 44 Components were identified representing 97.3%, with 1,8-cineole (34.62%), camph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e58d8048c5a8d50217d03a81884a976
https://doi.org/10.1080/14786419.2019.1602830

Antioxidant Flavonoids from Asteriscus maritimus

Autor: Habiba, Daroui-Mokaddem, Ahmed, Kabouche, Naima, Boutaghane, Claude-Alain, Calliste, Jean-Luc, Duroux, Zahia, Kabouche

Publikováno v: Natural product communications. 12(3)

One new flavonol glycoside, patuletin-7-Ο-[6-Ο-caffeoyl-2-Ο-[(S)-3-hydroxyisobutanoyl]glucopyranoside] (astermaritimoside) (1) and four known flavonoids, patuletin-7-Ο-β-[-6-Ο-[(S)-3-hydroxyisobutanoyl]glucopyranoside] (2), patuletin-7-Ο-[6-Ο

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef2b575c2f0875133f9f3702b04b0bd1
https://pubmed.ncbi.nlm.nih.gov/30549891

Acylglucuronide in alkaline conditions: migration vs. hydrolysis

Autor: Patrick Trouillas, Picard Nicolas, Florent Di Meo, Michele Steel, Jean-Luc Duroux, Pierre Marquet

Publikováno v: J Mol Model
J Mol Model, 2013, 19 (6), pp.2423-32. ⟨10.1007/s00894-013-1790-3⟩
Journal of Molecular Modeling
Journal of Molecular Modeling, Springer Verlag (Germany), 2013, 19 (6), pp.2423-2432. ⟨10.1007/s00894-013-1790-3⟩

International audience; This work rationalizes the glucuronidation process (one of the reactions of the phase II metabolism) for drugs having a carboxylic acid moiety. At this stage, acylglucuronides (AG) metabolites are produced, that have largely b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4225378a5f3d505c888da7091da70d2
https://doi.org/10.1007/s00894-013-1790-3

UV/Visible spectra of natural polyphenols: A time-dependent density functional theory study

Autor: Patrick Trouillas, Jean-Luc Duroux, Johannes Gierschner, El Hassane Anouar

Publikováno v: Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
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In addition to their numerous biological activities, natural and hemisynthetic polyphenols contribute to the large variety of colours (from red to violet) in nature (e.g., fruit, vegetables, leaves and petals). In order to understand the colour varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31218a4303d9b86fd8e9c927000c19c
https://doi.org/10.1016/j.foodchem.2011.08.034