Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Jean‐Ju Chung"'
Autor:
Jae Yeon Hwang, Pengxin Chai, Shoaib Nawaz, Jungmin Choi, Francesc Lopez-Giraldez, Shabir Hussain, Kaya Bilguvar, Shrikant Mane, Richard P Lifton, Wasim Ahmad, Kai Zhang, Jean-Ju Chung
Publikováno v:
eLife, Vol 12 (2023)
Radial spokes (RS) are T-shaped multiprotein complexes on the axonemal microtubules. Repeated RS1, RS2, and RS3 couple the central pair to modulate ciliary and flagellar motility. Despite the cell type specificity of RS3 substructures, their molecula
Externí odkaz:
https://doaj.org/article/d9710931c5ef46c08e60e959f221e930
Autor:
Yanhe Zhao, Huafeng Wang, Caroline Wiesehoefer, Naman B. Shah, Evan Reetz, Jae Yeon Hwang, Xiaofang Huang, Tse-en Wang, Polina V. Lishko, Karen M. Davies, Gunther Wennemuth, Daniela Nicastro, Jean-Ju Chung
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Sperm motility and male fertility requires function of the CatSper calcium channels. Here, using cryo-electron tomography, authors visualize the native in-cell 3D structure and higher-order organization of the CatSper as long zigzag rows along the sp
Externí odkaz:
https://doaj.org/article/4868ad620dbe4a0693d8cadf3f45760a
Autor:
Jae Yeon Hwang, Shoaib Nawaz, Jungmin Choi, Huafeng Wang, Shabir Hussain, Mehboob Nawaz, Francesc Lopez-Giraldez, Kyungjo Jeong, Weilai Dong, Jong-Nam Oh, Kaya Bilguvar, Shrikant Mane, Chang-Kyu Lee, Christopher Bystroff, Richard P. Lifton, Wasim Ahmad, Jean-Ju Chung
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Asthenozoospermia accounts for over 80% of primary male infertility cases. Reduced sperm motility in asthenozoospermic patients are often accompanied by teratozoospermia, or defective sperm morphology, with varying severity. Multiple morphological ab
Externí odkaz:
https://doaj.org/article/6669c93854444ae6940b376601329ebc
Publikováno v:
eLife, Vol 9 (2020)
Out of millions of ejaculated sperm, a few reach the fertilization site in mammals. Flagellar Ca2+ signaling nanodomains, organized by multi-subunit CatSper calcium channel complexes, are pivotal for sperm migration in the female tract, implicating C
Externí odkaz:
https://doaj.org/article/0039e6bfca1a4690b949618c29108959
Autor:
Luke L McGoldrick, Jean-Ju Chung
Publikováno v:
eLife, Vol 9 (2020)
An automated high-throughput platform can screen for molecules that change the motility of sperm cells and their ability to fertilize.
Externí odkaz:
https://doaj.org/article/e4749ddded094ee7adc7c7f6d5f77f86
Publikováno v:
Cells, Vol 10, Iss 5, p 1047 (2021)
Males have evolved species-specifical sperm morphology and swimming patterns to adapt to different fertilization environments. In eutherians, only a small fraction of the sperm overcome the diverse obstacles in the female reproductive tract and succe
Externí odkaz:
https://doaj.org/article/b8c446edb5e048868c44255d4b633d54
Autor:
Jean-Ju Chung, Kiyoshi Miki, Doory Kim, Sang-Hee Shim, Huanan F Shi, Jae Yeon Hwang, Xinjiang Cai, Yusuf Iseri, Xiaowei Zhuang, David E Clapham
Publikováno v:
eLife, Vol 6 (2017)
We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe mal
Externí odkaz:
https://doaj.org/article/8a2945ab64c74cf1abc30e982df1d112
Autor:
Jae Yeon Hwang, Jean-Ju Chung
Publikováno v:
Physiology. 38:125-140
The flagellar-specific Ca2+ channel CatSper is the predominant Ca2+ entry site in mammalian sperm. CatSper-mediated Ca2+ signaling affects nearly every event that regulates sperm to acquire fertilizing capability. In this review, we summarize some of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5403d1fc98920ea3725d2464ab7e36e
https://doi.org/10.1152/physiol.00028.2022
https://doi.org/10.1152/physiol.00028.2022
