Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Jean‐Francois Pittet"'
Autor:
Phoibe Renema, Jean-Francois Pittet, Angela P Brandon, Sixto M Leal, Steven Gu, Grace Promer, Andrew Hackney, Phillip Braswell, Andrew Pickering, Grace Rafield, Sarah Voth, Ron Balczon, Mike T Lin, K Adam Morrow, Jessica Bell, Jonathon P Audia, Diego Alvarez, Troy Stevens, Brant M Wagener
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298816 (2024)
BackgroundBacterial pneumonia and sepsis are both common causes of end-organ dysfunction, especially in immunocompromised and critically ill patients. Pre-clinical data demonstrate that bacterial pneumonia and sepsis elicit the production of cytotoxi
Externí odkaz:
https://doaj.org/article/7e24ba0ec0fc45c7b6da14ffbca953db
Autor:
Zhenhan Li, Nadine Ludwig, Katharina Thomas, Sina Mersmann, Martin Lehmann, Dietmar Vestweber, Jean-Francois Pittet, Hernando Gomez, John A. Kellum, Jan Rossaint, Alexander Zarbock
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Acute kidney injury (AKI) may be induced by different causes, including renal ischemia-reperfusion injury and sepsis, which represent the most common reasons for AKI in hospitalized patients. AKI is defined by reduced urine production and/or increase
Externí odkaz:
https://doaj.org/article/643a80cce42f42a292654931518c71c2
Autor:
Ranu Surolia, Fu Jun Li, Zheng Wang, Mahendra Kashyap, Ritesh Kumar Srivastava, Amie M. Traylor, Pooja Singh, Kevin G. Dsouza, Harrison Kim, Jean-Francois Pittet, Jaroslaw W. Zmijewski, Anupam Agarwal, Mohammad Athar, Aftab Ahmad, Veena B. Antony
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Despite the high morbidity and mortality among patients with extensive cutaneous burns in the intensive care unit due to the development of acute respiratory distress syndrome, effective therapeutics remain to be determined. This is primarily because
Externí odkaz:
https://doaj.org/article/11229075bb154bd8907ed402be32ccab
Autor:
Kierra S. Hardy, Amanda N. Tuckey, Phoibe Renema, Mita Patel, Abu-Bakr Al-Mehdi, Domenico Spadafora, Cody A. Schlumpf, Robert A. Barrington, Mikhail F. Alexeyev, Troy Stevens, Jean-Francois Pittet, Brant M. Wagener, Jon D. Simmons, Diego F. Alvarez, Jonathon P. Audia
Publikováno v:
Toxins, Vol 14, Iss 2, p 152 (2022)
The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied exoenzymes, ExoU causes rapid cell damage and death. ExoU is a phosp
Externí odkaz:
https://doaj.org/article/c9f84dac36d44282a31de0221c698954
Autor:
Maroof Husain, Eugene J. Becker, Jr., Nathaniel B. Bone, Amy Schmitt, Jean-Francois Pittet, Jaroslaw W. Zmijewski
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101651- (2020)
Trauma and sepsis are frequent causes of immunosuppression and risk of secondary bacterial infections and mortality among critically ill patients. Reduced activity of neutrophil NADPH oxidase 2 (NOX2) and impaired bacterial killing are among the majo
Externí odkaz:
https://doaj.org/article/3fc45299a1494c6c8a454717fdf1b05a
Autor:
Brant M Wagener, Parker J Hu, Joo-Yeun Oh, Cilina A Evans, Jillian R Richter, Jaideep Honavar, Angela P Brandon, Judy Creighton, Shannon W Stephens, Charity Morgan, Randal O Dull, Marisa B Marques, Jeffrey D Kerby, Jean-Francois Pittet, Rakesh P Patel
Publikováno v:
PLoS Medicine, Vol 16, Iss 11, p e1002991 (2019)
[This corrects the article DOI: 10.1371/journal.pmed.1002522.].
Externí odkaz:
https://doaj.org/article/784fd654e2c245219e86399b0c05c437
Publikováno v:
Toxins, Vol 13, Iss 11, p 776 (2021)
Pseudomonas (P.) aeruginosa is an opportunistic pathogen that causes serious infections and hospital-acquired pneumonia in immunocompromised patients. P. aeruginosa accounts for up to 20% of all cases of hospital-acquired pneumonia, with an attributa
Externí odkaz:
https://doaj.org/article/1626237b927449d69dacde3be9a92005
Autor:
Duraid Younan, T. Mark Beasley, David C. Pigott, C. Blayke Gibson, John P. Gullett, Jeffrey Richey, Jean-Francois Pittet, Ahmed Zaky
Publikováno v:
Critical Ultrasound Journal, Vol 9, Iss 1, Pp 1-7 (2017)
Abstract Background Conventional echocardiographic technique for assessment of volume status and cardiac contractility utilizes left ventricular end-diastolic area (LVEDA) and fractional area of change (FAC), respectively. Our goal was to find a tech
Externí odkaz:
https://doaj.org/article/5271555588374e22927e653609bfc28e
Autor:
Joo-Yeun Oh, Jennifer Hamm, Xin Xu, Kristopher Genschmer, Ming Zhong, Jeffrey Lebensburger, Marisa B. Marques, Jeffrey D. Kerby, Jean-Francois Pittet, Amit Gaggar, Rakesh P. Patel
Publikováno v:
Redox Biology, Vol 9, Iss C, Pp 167-177 (2016)
Cell-free heme (CFH) and hemoglobin (Hb) have emerged as distinct mediators of acute injury characterized by inflammation and microcirculatory dysfunction in hemolytic conditions and critical illness. Several reports have shown changes in Hb and CFH
Externí odkaz:
https://doaj.org/article/89cd8963160d4e71ba8c2e87f47c8c89
Autor:
Mingkuan Lin, Christoph J. Griessenauer, Robert M. Starke, R. Shane Tubbs, Mohammadali M. Shoja, Paul M. Foreman, Nilesh A. Vyas, Beverly C. Walters, Mark R. Harrigan, Philipp Hendrix, Winfield S. Fisher, Jean‐Francois Pittet, Mali Mathru, Robert H. Lipsky
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 8, Pp n/a-n/a (2019)
Abstract Background Aneurysmal subarachnoid hemorrhage (aSAH) has high fatality and permanent disability rates due to the severe damage to brain cells and inflammation. The SERPINE1 gene that encodes PAI‐1 for the regulation of tissue plasminogen a
Externí odkaz:
https://doaj.org/article/003d503ce0da44faa2f8ec1c34f0885d