Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Jean‐François Ottavi"'
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Akademický článek
Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors
Autor: Elena Barbon, Gabriel Ayme, Amel Mohamadi, Jean‐François Ottavi, Charlotte Kawecki, Caterina Casari, Sebastien Verhenne, Solenne Marmier, Laetitia van Wittenberghe, Severine Charles, Fanny Collaud, Cecile V Denis, Olivier D Christophe, Federico Mingozzi, Peter J Lenting
Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-18 (2020)
Abstract Novel therapies for hemophilia, including non‐factor replacement and in vivo gene therapy, are showing promising results in the clinic, including for patients having a history of inhibitor development. Here, we propose a novel therapeutic
Externí odkaz: https://doaj.org/article/4434607219fc41c0b6465b55049e9dff
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2
A single‐domain antibody that blocks factor VIIa activity in the absence but not presence of tissue factor
Autor: Jean-François Ottavi, Peter J. Lenting, Charlotte Kawecki, Cécile V. Denis, Olivier D. Christophe, Stephen Ferrière, Alexandre Kauskot
Publikováno v: Journal of Thrombosis and Haemostasis. 17:2035-2046
Background Activated factor VII (FVIIa) is pertinent to the initiation of blood coagulation. Proteolytic and amidolytic activity of FVIIa are greatly enhanced by its cofactor, tissue factor (TF). Objective We aimed to generate a single-domain antibod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0dfb6cb77d311eddc93a4be8fc47ec
https://doi.org/10.1111/jth.14615
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3
Tspan15 Is a New Stemness-Related Marker in Hepatocellular Carcinoma
Autor: Taous Ait Saadi, François Le Naour, Nazha Sidahmed-Adrar, Philippe Mauduit, Nassima Benzoubir, Catherine Guettier, Mohamed Bou Saleh, Christophe Desterke, Jean-François Ottavi
Publikováno v: Proteomics
Proteomics, Wiley-VCH Verlag, 2019, 19 (21-22), pp.1900025. ⟨10.1002/pmic.201900025⟩
Proteomics, 2019, 19 (21-22), pp.1900025. ⟨10.1002/pmic.201900025⟩
Hepatocellular carcinoma (HCC) is the second cause of cancer-related deaths worldwide. A clearer understanding of the molecular mechanisms underlying tumor growth and invasiveness remains crucial for developing new therapies. Here, the expression of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d982d7253efc40fa4a9b4bd3866e7b
https://pubmed.ncbi.nlm.nih.gov/31390680
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4
Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression
Autor: Jean-François Ottavi, Brigitte Bressac-de Paillerets, Karine Bille, Gian Marco De Donatis, Guillaume Bossis, Thomas Strub, Mickaël Ohanna, Stéphane Rocchi, Jean-Philippe Lacour, Véronique Hofman, Irwin Davidson, Sandrine Marchetti, Yann Cheli, Marie-Christine Birling, Paul Hofman, Thomas Luc, Jean-Christophe Marine, Frederic Luciano, Fanélie-Marie Jouenne, Marina Boncompagni, Corine Bertolotto, Flavie Luciani, Marie-Françoise Avril, Caroline Bonet, Justine Leclerc, N. Poulalhon, Robert Ballotti
Publikováno v: JNCI: Journal of the National Cancer Institute
JNCI: Journal of the National Cancer Institute, Oxford University Press (OUP), 2017, 109 (8), pp.djw340. ⟨10.1093/jnci/djw340⟩
JNCI: Journal of the National Cancer Institute, 2017, 109 (8), pp.djw340. ⟨10.1093/jnci/djw340⟩
International audience; BACKGROUND:MITF encodes an oncogenic lineage-specific transcription factor in which a germline mutation ( MITFE318K ) was identified in human patients predisposed to both nevus formation and, among other tumor types, melanoma.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae524e1f3efdb7a5d06007dab8159bc
https://www.hal.inserm.fr/inserm-02529960
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5
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
Autor: Emmanuel Dornier, Franck Coumailleau, Jean-François Ottavi, Julien Moretti, Claude Boucheix, Philippe Mauduit, François Schweisguth, Eric Rubinstein
Publikováno v: Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2012, 199 (3), pp.481-496. ⟨10.1083/jcb.201201133⟩
Journal of Cell Biology, 2012, 199 (3), pp.481-496. ⟨10.1083/jcb.201201133⟩
International audience; The metalloprotease ADAM10/Kuzbanian catalyzes the ligand-dependent ectodomain shedding of Notch receptors and activates Notch. Here, we show that the human tetraspanins of the evolutionary conserved TspanC8 subfamily (Tspan5,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e20352bf39f67c5156bc01cad2e366
https://doi.org/10.1083/jcb.201201133
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6
Correction: TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
Autor: Claude Boucheix, Julien Moretti, François Schweisguth, Philippe Mauduit, Franck Coumailleau, Jean-François Ottavi, Eric Rubinstein, Emmanuel Dornier
Publikováno v: The Journal of Cell Biology
TspanC8 tetraspanins have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch activation.
The metalloprotease ADAM10/Kuzbanian catalyzes the ligand-dependent ectodomain shedding of Notch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd4c54e0058962247696213c5cd2ba2
http://europepmc.org/articles/PMC4878088
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